Covalent conjugation of doxorubicin to polydopamine on the surface of single-atom nanozyme for effective synergistic cancer therapy DOI
Jing Liu, Minjuan Wang, Xing Yang

et al.

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Language: Английский

Enzyme- and Nanozyme-Based food allergen detections: from natural biocatalysts to rational engineering approaches DOI Creative Commons
Shuang Wu, Jinlong Zhao, Youfa Wang

et al.

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 105016 - 105016

Published: April 1, 2025

Language: Английский

Citations

0
NIR II light-driven nanomotor synergistically enhances immunogenic cell death through photothermal and chemodynamic therapy for melanoma immunotherapy DOI
Xuan Hu, Ziyan Shen,

H. Hao

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 694, P. 137688 - 137688

Published: April 23, 2025

Language: Английский

Citations

0
Chimeric Nanozyme Bacterial Outer Membrane Vesicles Reprograming Tumor Microenvironment for Safe and Efficient Anticancer Therapy DOI Creative Commons
Fan Zhang, Qianqian Li,

Haibing Dai

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Abstract This study presents an innovative approach utilizing a biocompatible shell to shield bacterial outer membrane vesicles (OMVs) and incorporate Fe ions ultrasmall Au nanoparticles develop combined tumor therapeutic strategy. These chimeric nanozyme shells effectively reduce the toxicity of OMVs during circulation promote their accumulation in tissues. In microenvironment, act as nanozymes, catalyzing glucose consumption elevating H₂O₂ levels. The increased subsequently reacts with released induce immunogenic cell death through iron‐mediated chemodynamic mechanisms. Simultaneously, release tumor‐associated antigens synergistically stimulates immune response. cascade nanozyme‐catalyzed reactions, effects, activation results efficient inhibition.

Language: Английский

Citations

0
Camouflaged Nanozymes with Oxidation‐Promoting Activities Triggering Ferroptosis for Radio‐Immunotherapy DOI Creative Commons
Kun Qiao, Yongbiao Huang, Shipeng Ning

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Abstract Radioresistance presents a substantial obstacle to achieving optimal therapeutic outcomes for breast cancer treatment. In this study, we develop cell membrane (CM) ‐ coated nanozyme system (MPPC@CM), specifically designed radioimmunotherapy address issue. This innovative involves the in situ reduction of platinum and palladium on mesoporous silica nanospheres, followed by functionalization with cinnamaldehyde via surface grafting. The CM coating endows enhanced tumor‐specific targeting capability due its homing properties. Upon uptake tumor cells, MPPC@CM catalytically generates O 2 from H , mitigating hypoxic microenvironment reducing radioresistance. intracellular glutathione depletion mediated Michael addition reactions concurrently disrupts endogenous antioxidant defenses against reactive oxygen species (ROS). redox imbalance is synergistically amplified through nanozyme‐mediated catalytic activities including both peroxidase‐like oxidase‐like functions. resultant massive ROS accumulation establishes self‐reinforcing oxidative cascade that ultimately induces functional inactivation peroxidase 4. immunosuppressive environment remodeled disturbance balance, which accelerates ferroptosis increases CD8 + T‐cell infiltration dendritic maturation. Overall, membrane‐camouflaged holds significant potential enhance efficacy radioimmunotherapy.

Language: Английский

Citations

0
Covalent conjugation of doxorubicin to polydopamine on the surface of single-atom nanozyme for effective synergistic cancer therapy DOI
Jing Liu, Minjuan Wang, Xing Yang

et al.

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Language: Английский

Citations

0