Synergistic Gas Therapy and Targeted Interventional Ablation With Size‐Controllable Arsenic Sulfide (As2S3) Nanoparticles for Effective Elimination of Localized Cancer Pain DOI

Yu Tang,

Jiyun Zhang,

Yuan Yuan

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 2, 2024

Abstract The elimination of localized cancer pain remains a globally neglected challenge. A potential solution lies in combining gas therapy with targeted interventional ablation therapy. In this study, HA‐As 2 S 3 nanoparticles controlled sizes are synthesized using different molecular weights sodium hyaluronate (HA) as supramolecular scaffold. Initially, HA co‐assembles arsenic ions (As 3+ ) via coordinate bonds, forming scaffold intermediates. These intermediates, varying size, then react sulfur to produce size‐controlled particles. This approach demonstrates that enable precise control over the particle size sulfide, offering straightforward and environmentally friendly method for synthesizing metal sulfide an acidic environment, release hydrogen sulfide(H S) As . released directly damage tumor mitochondria, leading substantial reactive oxygen species (ROS) production from mitochondria. Concurrently, H inhibits activity catalase (CAT) complex IV, preventing beneficial decomposition ROS disrupting electron transfer mitochondrial respiratory chain. Consequently, it is found significantly enhances induced by nanodrugs, effectively killing local tumors ultimately eliminating mice.

Language: Английский

Harnessing Akkermansia muciniphila for astaxanthin delivery: A promising strategy for alleviating inflammatory bowel diseases DOI

Xue-Ke Ma,

Xu Tian, Xin Shao

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106023 - 106023

Published: Feb. 1, 2025

Language: Английский

Citations

0
A DNA Nanopatch‐Bacteriophage System Targeting Streptococcus Gallolyticus for Inflammatory Bowel Disease Treatment and Colorectal Cancer Prevention DOI Open Access

Yadan Zhao,

Mengna Zhu,

Yufan Ling

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Persistent inflammation in inflammatory bowel disease (IBD) increases Streptococcus gallolyticus (Sg) colonization, increasing the risk of colorectal cancer progression via Sg-activated cyclooxygenase-2 (COX-2) pathway and β-catenin upregulation. This study presents Sg-specific bacteriophages modified with DNA nanopatches (DNPs@P) designed to treat IBD prevent Sg-induced malignancy. The DNPs are composed origami nanosheets phage capture strands. scavenge reactive oxygen species, enhancing therapeutic efficacy phages while targeting lysing pathogenic bacteria. Coating an enteric polymer, DNPs@P ensures effective delivery gastrointestinal tract. These findings demonstrate significant restoration colonic length, reduced inflammation, improved gut microbiota diversity compared current clinical treatments. Additionally, effectively prevents tumourigenesis mouse models. approach a promising strategy for treating diseases by remodeling microenvironment, addressing critical gap therapies.

Language: Английский

Citations

0
Integrating serum pharmacochemistry, network pharmacology, metabolomics and 16S rRNA sequencing to explore the mechanism of total flavonoids from Flemingia philippinensis in treating collagen induced arthritis rats DOI

Jingwen Qiu,

Yingyin Zhang,

Kuo Chen

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156531 - 156531

Published: Feb. 16, 2025

Language: Английский

Citations

0
Nanomaterials for targeted drug delivery for immunotherapy of digestive tract tumors DOI Creative Commons
Mingzhu Li,

Ningxin Li,

Haozhe Piao

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 5, 2025

The incidence and mortality rates of digestive tract tumors, especially gastric colorectal cancers, are high worldwide. Owing to their unique advantages, such as efficient drug loading, safety, targeting properties, nanoparticles (NPs) have demonstrated great potential in the treatment gastrointestinal tumors. However, practical application is limited by several factors, costs, few clinical trials, long approval periods. In this review, we summarize three types immunotherapeutic nanomaterial drugs for tumors: organic, inorganic, hybrid nanomaterials. This article also discusses current status research development field advantages each type material provide theoretical references developing new advancing research.

Language: Английский

Citations

0
Inflammatory Microenvironment-Responsive Microsphere Vehicles Modulating Gut Microbiota and Intestinal Inflammation for Intestinal Stem Cell Niche Remodeling in Inflammatory Bowel Disease DOI
Xing Zhao,

Liya Wang,

Yajun Fu

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Intestinal stem cells (ISCs) engage in proliferation to maintain a stable cell population and differentiate into functional epithelial subpopulations. This intricate process is upheld by various signals derived from the host gut microbiota, establishing an ISC niche. However, during inflammatory bowel disease (IBD), this signaling niche undergoes dramatic changes, leading impaired hindered restoration of damaged intestinal barrier. study introduces microenvironment-responsive microsphere vehicles designed remodel niche, offering approach treat IBD. Using advanced emulsion technique, these specifically target colonic inflammation sites, delivering responsive release MXene l-arginine. delivery system formulated modulate flora immune responses effectively. l-arginine converted nitric oxide regulate microbiome, while serves as nanoimmunomodulator stabilize homeostasis. Our findings demonstrate that anti-inflammatory properties microspheres are key promoting repair remodeling highlights role antioxidant agents indirectly support function regeneration.

Language: Английский

Citations

0
Probiotic Membrane-Modified Nanocomposite Alleviates Inflammation and Microbiota Dysbiosis in Colitis by Scavenging Oxidative Stress and Restoring Immune Homeostasis DOI
Huan Yang, Xu Zhang,

Jianshuang Wu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Inflammatory bowel disease (IBD) is a complex chronic intestinal disorder in which excessive oxidative stress, dysregulated immune response, and microbiota dysbiosis contribute to recurrent episodes of inflammation the colonic mucosa. Current clinical treatments focusing solely on resolution often exhibit limited efficacy due inability fundamentally improve pathological microenvironment. Herein, probiotic membrane-modified drug delivery nanocomposite, namely, MPDA@Cur@EM, developed for comprehensive treatment IBD. It contains two components: curcumin-loaded mesoporous polydopamine nanoparticle (MPDA@Cur) as core Escherichia coli Nissle 1917 outer membrane (EM) surface. For MPDA@Cur, microenvironment triggers responsive release curcumin. Importantly, MPDA@Cur can effectively alleviate inflammatory response LPS-activated macrophages through MPDA-mediated ROS scavenging curcumin-induced M2 polarization. In dextran sulfate sodium (DSS)-induced colitis model, EM coating not only allows targeting enrichment orally administered MPDA@Cur@EM inflamed mucosa, but also participates regulation flora. Consequently, efficiently attenuates reaction restores barrier functions, demonstrated by multipronged manner restoring redox balance, remodeling homeostasis, reshaping gut microecology. Collectively, this work provides safe promising codelivery strategy product, antioxidative nanoenzyme, therapeutic management

Language: Английский

Citations

0
Metabolomics Insights into Gut Microbiota and Functional Constipation DOI Creative Commons
Fan Zheng,

Yong Yang,

Guanting Lu

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(4), P. 269 - 269

Published: April 12, 2025

Background: The composition and metabolic activity of the gut microbiota play a crucial role in various health conditions, including occurrence development chronic constipation. Recent metabolomic advances reveal that microbiota-derived metabolites—such as SCFAs, bile acids, neurotransmitters, microbial gases—play critical roles regulating intestinal function. Methods: We systematically analyzed current literature on metabolomics This review consolidates findings from high-throughput techniques (GC-MS, LC-MS, NMR) comparing profiles constipated patients with healthy individuals. It also examines diagnostic improvements personalized treatments, fecal transplantation neuromodulation, guided by these insights. Results: shows reduced SCFA levels impair motility promote inflammation. An altered acid metabolism—with decreased secondary acids like deoxycholic acid—disrupts receptor-mediated signaling, further affecting motility. Additionally, imbalances amino metabolism neurotransmitter production contribute to neuromuscular dysfunction, while variations gas (e.g., methane vs. hydrogen) modulate transit. Conclusions: Integrating research clarifies how specific metabolites regulate These insights offer promising directions for precision diagnostics targeted therapies restore balance improve

Language: Английский

Citations

0
Rationally constructing the theranostics hydrogels for targeted CT imaging and healing of inflammatory bowel disease DOI

Zongling Xiong,

Feng Cai, Jingyi Tang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162986 - 162986

Published: April 1, 2025

Language: Английский

Citations

0
Oral natural material hydrogels: a new strategy for enhancing oral drug delivery efficiency DOI
Qiwei Yang, Xiang Xi, Han Wang

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 28

Published: May 26, 2025

Oral administration, owing to its high patient compliance and favorable controllability, is widely employed in clinical settings; however, the efficacy often constrained by gastrointestinal environment's impact on bioavailability. As demand for biocompatibility biodegradability biomedical applications intensifies, natural hydrogel-based oral drug delivery systems have gained substantial attention as promising carriers. In this study, we introduce a variety of materials, revealing their advantages enhancing bioavailability targeting capabilities. Through both physical chemical crosslinking mechanisms, successfully demonstrate hydrogels exhibiting excellent mechanical properties biocompatibility. Furthermore, analyze potential diverse across fields such gastrointestinal, metabolic, oncological, immunotherapeutic diseases. By synthesizing recent advances area, aim elucidate critical role these can play biomedicine. Our findings suggest that materials possess broad prospects delivery, advocating continued exploration application facilitate development optimization novel therapeutic modalities. This work provides vital theoretical foundation practical guidance future innovations technologies.

Language: Английский

Citations

0
Biomaterial-based therapeutic strategies for inflammatory bowel disease DOI

Wei Sun,

Zhibo Li, Xiaohao Zhang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123462 - 123462

Published: June 1, 2025

Language: Английский

Citations

0