Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 2, 2024
Abstract
The
elimination
of
localized
cancer
pain
remains
a
globally
neglected
challenge.
A
potential
solution
lies
in
combining
gas
therapy
with
targeted
interventional
ablation
therapy.
In
this
study,
HA‐As
2
S
3
nanoparticles
controlled
sizes
are
synthesized
using
different
molecular
weights
sodium
hyaluronate
(HA)
as
supramolecular
scaffold.
Initially,
HA
co‐assembles
arsenic
ions
(As
3+
)
via
coordinate
bonds,
forming
scaffold
intermediates.
These
intermediates,
varying
size,
then
react
sulfur
to
produce
size‐controlled
particles.
This
approach
demonstrates
that
enable
precise
control
over
the
particle
size
sulfide,
offering
straightforward
and
environmentally
friendly
method
for
synthesizing
metal
sulfide
an
acidic
environment,
release
hydrogen
sulfide(H
S)
As
.
released
directly
damage
tumor
mitochondria,
leading
substantial
reactive
oxygen
species
(ROS)
production
from
mitochondria.
Concurrently,
H
inhibits
activity
catalase
(CAT)
complex
IV,
preventing
beneficial
decomposition
ROS
disrupting
electron
transfer
mitochondrial
respiratory
chain.
Consequently,
it
is
found
significantly
enhances
induced
by
nanodrugs,
effectively
killing
local
tumors
ultimately
eliminating
mice.
MedComm – Biomaterials and Applications,
Journal Year:
2024,
Volume and Issue:
3(4)
Published: Nov. 28, 2024
Abstract
Nanogels
(NGs)
are
considered
as
a
kind
of
nanoscale
hydrogels
(<200
nm)
endowing
with
the
functions
both
nanomaterials
and
hydrogels.
In
last
20
years,
NGs
have
garnered
significant
attention
due
to
their
versatility
adaptability.
Herein,
comprehensive
overview
latest
advancements
current
research
status
is
provided,
particular
focus
on
synthesis
strategies
involving
physical
chemical
cross‐linking
methods,
well
advantages
in
drug
loading
responsive
release.
Based
diverse
design
NGs,
four
key
biomedical
applications,
including
inflammation
therapy,
regenerative
medicine,
bioimaging
tumor
therapy
further
summarized
discussed.
Moreover,
existed
inherent
challenges
facing
proposed,
while
highlighting
potential
revolutionize
therapeutic
diagnostic
approaches.
Finally,
we
look
forward
development
promising
potentials
applications.
This
review
aims
serve
valuable
reference
for
researchers,
providing
some
insights
into
evolving
landscape
advanced
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: July 30, 2024
The
lack
of
a
simple
design
strategy
to
obtain
ideal
conjugated
polymers
(CPs)
with
high
absorbance
and
fluorescence
(FL)
in
the
near-infrared-II
(NIR-II;
1000–1700
nm)
region
still
hampers
success
NIR-II
light-triggered
phototheranostics.
Herein,
novel
phototheranostic
nanoparticles
(PPN-NO
NPs)
were
successfully
prepared
by
coloading
cationic
CPs
(PBC-co-PBF-NMe3)
NO
donor
(S-nitroso-N-acetylpenicillamine,
SNAP)
onto
1:1
mixture
DSPE-PEG5000
dimyristoylphosphatidylcholine
(DMPC)
for
FL
photoacoustic
(PA)
imaging-guided
low-temperature
photothermal
therapy
(PTT)
gas
combination
cancer
treatment.
A
precise
dually
enhanced
tactic
was
proposed
herein
integrating
flexible
nonconjugated
segments
(C6)
into
backbone
incorporating
quaternary
ammonium
salt
units
side
chain,
which
considerably
increased
radiative
decay
pathway,
resulting
desirable
intensity
balanced
absorption
NIR
PTT
properties.
PPN-NO
NPs
exhibited
distinguished
PA
imaging
performance
tumor-bearing
mice
models.
Furthermore,
effect
could
initiate
release
upon
980
nm
laser
irradiation,
efficiently
suppressing
tumor
growth
owing
vitro
vivo.
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 2, 2024
Abstract
The
elimination
of
localized
cancer
pain
remains
a
globally
neglected
challenge.
A
potential
solution
lies
in
combining
gas
therapy
with
targeted
interventional
ablation
therapy.
In
this
study,
HA‐As
2
S
3
nanoparticles
controlled
sizes
are
synthesized
using
different
molecular
weights
sodium
hyaluronate
(HA)
as
supramolecular
scaffold.
Initially,
HA
co‐assembles
arsenic
ions
(As
3+
)
via
coordinate
bonds,
forming
scaffold
intermediates.
These
intermediates,
varying
size,
then
react
sulfur
to
produce
size‐controlled
particles.
This
approach
demonstrates
that
enable
precise
control
over
the
particle
size
sulfide,
offering
straightforward
and
environmentally
friendly
method
for
synthesizing
metal
sulfide
an
acidic
environment,
release
hydrogen
sulfide(H
S)
As
.
released
directly
damage
tumor
mitochondria,
leading
substantial
reactive
oxygen
species
(ROS)
production
from
mitochondria.
Concurrently,
H
inhibits
activity
catalase
(CAT)
complex
IV,
preventing
beneficial
decomposition
ROS
disrupting
electron
transfer
mitochondrial
respiratory
chain.
Consequently,
it
is
found
significantly
enhances
induced
by
nanodrugs,
effectively
killing
local
tumors
ultimately
eliminating
mice.
