Targeted delivery of MerTK protein via cell membrane engineered nanoparticle enhances efferocytosis and attenuates atherosclerosis in diabetic ApoE−/− Mice
Shuo Qiu,
No information about this author
Jiahan Liu,
No information about this author
Jianmei Chen
No information about this author
et al.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: April 13, 2024
Abstract
Background
Clearance
of
apoptotic
cells
by
efferocytosis
is
crucial
for
prevention
atherosclerosis
progress,
and
impaired
contributes
to
the
aggravated
atherosclerosis.
Results
In
this
study,
we
found
that
diabetic
ApoE
–/–
mice
showed
as
hyperglycemia
damaged
capacity
at
least
partially
due
decreased
expression
Mer
tyrosine
kinase
(MerTK)
on
macrophages.
To
locally
restore
MerTK
in
macrophages
plaque,
hybrid
membrane
nanovesicles
(HMNVs)
were
thus
developed.
Briefly,
cell
from
overexpressing
RAW264.7
transferrin
receptor
(TfR)
HEK293T
mixed
with
DOPE
polymers
produce
designated
HMNVs.
HMNVs
could
fuse
recipient
increased
macrophages,
which
turn
restored
capacity.
Upon
intravenous
administration
into
mice,
superparamagnetic
iron
oxide
nanoparticles
(SMN)
decorated
accumulated
aorta
site
significantly
under
magnetic
navigation,
where
cleared
efficiently
inflammation.
Conclusions
Our
study
indicates
decrease
regional
restoration
plaque
via
be
a
promising
therapeutic
approach.
Graphic
Language: Английский
Open‐Source Throttling of CD8+ T Cells in Brain with Low‐Intensity Focused Ultrasound‐Guided Sequential Delivery of CXCL10, IL‐2, and aPD‐L1 for Glioblastoma Immunotherapy
Lei Dong,
No information about this author
Yini Zhu,
No information about this author
Haoge Zhang
No information about this author
et al.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(44)
Published: Sept. 12, 2024
Abstract
Improving
clinical
immunotherapy
for
glioblastoma
(GBM)
relies
on
addressing
the
immunosuppressive
tumor
microenvironment
(TME).
Enhancing
CD8
+
T
cell
infiltration
and
preventing
its
exhaustion
holds
promise
effective
GBM
immunotherapy.
Here,
a
low‐intensity
focused
ultrasound
(LIFU)‐guided
sequential
delivery
strategy
is
developed
to
enhance
cells
activity
in
region.
The
of
CXC
chemokine
ligand
10
(CXCL10)
recruit
interleukin‐2
(IL‐2)
reduce
their
termed
an
“open‐source
throttling”
strategy.
Consequently,
up
3.39‐fold
are
observed
with
LIFU‐guided
CXCL10,
IL‐2,
anti‐programmed
death
1
(aPD‐L1),
compared
free
aPD‐L1
group.
immune
checkpoint
inhibitors
(ICIs)
therapeutic
efficacy
substantially
enhanced
by
reversed
TME
due
expansion
cells,
resulting
elimination
tumor,
prolonged
survival
time,
long‐term
memory
establishment
orthotopic
mice.
Overall,
cytokine
ICIs
offers
which
may
present
promising
brain‐tumor
Language: Английский
Current status and future prospects of molecular imaging in targeting the tumor immune microenvironment
Xiang Wang,
No information about this author
Wen Shen,
No information about this author
Lan Yao
No information about this author
et al.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 22, 2025
Molecular
imaging
technologies
have
significantly
transformed
cancer
research
and
clinical
practice,
offering
valuable
tools
for
visualizing
understanding
the
complex
tumor
immune
microenvironment.
These
allow
non-invasive
examination
of
key
components
within
microenvironment,
including
cells,
cytokines,
stromal
providing
crucial
insights
into
biology
treatment
responses.
This
paper
reviews
latest
advancements
in
molecular
imaging,
with
a
focus
on
its
applications
assessing
interactions
Additionally,
challenges
faced
by
are
discussed,
such
as
need
highly
sensitive
specific
agents,
issues
data
integration,
difficulties
translation.
The
future
outlook
emphasizes
potential
to
enhance
personalized
through
integration
artificial
intelligence
development
novel
probes.
Addressing
these
is
essential
fully
realizing
improving
diagnosis,
treatment,
patient
outcomes.
Language: Английский
Shenqi Funeng Xingnao Prescription Alleviates Exercise-Induced Fatigue by Regulating the HIF-1/FoxO Signaling Pathway
Dong Xu,
No information about this author
Kai Gao,
No information about this author
Wei Zhang
No information about this author
et al.
Journal of Ethnopharmacology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 119881 - 119881
Published: April 1, 2025
Language: Английский
n‐Butanol Enables OMVs as Heat‐Responsive Nanometer Ultrasound Contrast Agents for Tumor Imaging
Lujiao Wang,
No information about this author
Song Yang,
No information about this author
Tao Zhou
No information about this author
et al.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 24, 2025
Abstract
Extracellular
vesicles,
such
as
Escherichia
coli
outer
membrane
vesicles
(OMVs),
have
been
widely
explored
carriers
for
contrast
agents,
yet
their
application
in
ultrasound
imaging
remains
limited.
In
this
study,
heat‐responsive
nB‐OMVs
are
developed
by
loading
n‐butanol
into
OMVs
(nB‐OMVs).
Upon
heating,
the
decreased
solubility
of
triggered
phase
separation
within
resulting
enhanced
signals,
including
fundamental,
harmonic,
and
subharmonic
components.
Experimental
results
demonstrated
that
retained
native
morphology
OMVs,
along
with
tumor‐targeting
accumulation
tumor
growth
inhibition
capabilities.
injection
induces
red
blood
cell
extravasation
tumors,
under
near‐infrared
(NIR)
irradiation,
these
extravasated
RBCs
acted
photothermal
mediators,
generating
a
localized
thermal
environment
activated
intratumoral
further
amplified
signal.
B‐mode
contrast‐enhanced
(CEUS)
imaging,
grayscale
intensities
increased
4.6‐
8.5‐fold,
respectively.
This
work
provides
promising
strategy
ultrasound‐based
using
extracellular
vesicles.
Language: Английский
CXCR4-Targeted Ultrasound Microbubbles for Imaging and Enhanced Chemotherapy/Immunotherapy in Liver Cancer
Yijie Qiu,
No information about this author
Jiaying Cao,
No information about this author
Jyh‐Fei Liao
No information about this author
et al.
Acta Biomaterialia,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 1, 2025
Language: Английский
Tumor perfusion enhancement by microbubbles ultrasonic cavitation reduces tumor glycolysis metabolism and alleviate tumor acidosis
Danxia Qiu,
No information about this author
Yangcheng He,
No information about this author
Yuyi Feng
No information about this author
et al.
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: July 18, 2024
The
tumor
microenvironment
is
increasingly
acknowledged
as
a
critical
contributor
to
cancer
progression,
mediating
genetic
and
epigenetic
alterations.
Beyond
diverse
cellular
interactions
from
the
microenvironment,
physicochemical
factors
such
acidosis
also
significantly
affect
dynamics.
Recent
research
has
highlighted
that
facilitates
invasion,
immune
escape,
metastasis,
resistance
therapies.
Thus,
noninvasive
measurement
of
acidity
development
targeted
interventions
represent
promising
strategies
in
oncology.
Techniques
like
contrast-enhanced
ultrasound
(CEUS)
can
effectively
assess
blood
perfusion,
while
ultrasound-stimulated
microbubble
cavitation
(USMC)
proven
enhance
perfusion.
We
therefore
aimed
determine
whether
CEUS
assesses
USMC
treatment
modulate
acidity.
Firstly,
we
tracked
perfusion
parameters
MCF7
models
compared
them
with
vivo
pH
recorded
by
microsensors.
found
peak
intensity
area
under
curve
correlated
well
pH.
further
conducted
on
tumor-bearing
mice,
changes
different
regions
before
after
its
impact
optimize
therapeutic
pressure.
discovered
1.0
Mpa
improved
Furthermore,
vascular
pathology
PGI2
assays
indicated
was
mainly
due
vasodilation
rather
than
angiogenesis.
More
importantly,
analysis
glycolysis-related
metabolites
enzymes
demonstrated
reduce
reducing
glycolysis.
These
findings
support
may
serve
potential
biomarker
modality
for
acidosis.
Language: Английский