Advances in Research of Hydrogel Microneedle-Based Delivery Systems for Disease Treatment DOI Creative Commons
Juan Cao, Bo Wu, Ping Yuan

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1571 - 1571

Published: Dec. 9, 2024

Microneedles (MNs), composed of multiple micron-scale needle-like structures attached to a base, offer minimally invasive approach for transdermal drug delivery by penetrating the stratum corneum and delivering therapeutic agents directly epidermis or dermis. Hydrogel microneedles (HMNs) stand out among various MN types due their excellent biocompatibility, high drug-loading capacity, tunable drug-release properties. This review systematically examines matrix materials fabrication methods HMN systems, highlighting advancements in natural synthetic polymers, explores applications treating conditions such as wound healing, hair loss, cardiovascular diseases, cancer. Furthermore, potential HMNs disease diagnostics is discussed. The identifies key challenges, including limited mechanical strength, efficiency, lack standardization, while proposing strategies overcome these issues. With integration intelligent design enhanced control over dosage safety, are poised revolutionize expand personalized medicine.

Language: Английский

Microneedles as Transdermal Drug Delivery System for Enhancing Skin Disease Treatment DOI Creative Commons

Chaoxiong Wu,

Qingyu Yu,

Chenlu Huang

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(12), P. 5161 - 5180

Published: Aug. 23, 2024

Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding viable resolution to the formidable barriers presented by cutaneous interface. This review examines MNs an advanced approach enhancing dermatological pathology management. It explores complex dermis structure and highlights limitations of traditional methods, emphasizing MNs' advantage bypassing stratum corneum deliver drugs directly subdermal matrix. The discourse outlines diverse typologies MNs, including solid, coated, hollow, hydrogel, dissolvable versions. Each type is characterized its unique applications benefits. treatise details deployment alleviation cancers, administration inflammatory dermatoses such psoriasis atopic dermatitis, their utility wound Additionally, paper contemplates prospects within realm aesthetic dermatology burgeoning market traction cosmetic MN formulations. summarizes scientific commercial challenges clinical adoption therapeutics, dosage calibration, pharmacodynamics, biocompatibility, patient compliance, sterilization, mass production, regulatory oversight. emphasizes need for ongoing research, innovation, harmonization overcome these obstacles fully realize potential treating skin diseases improving welfare. presents comprehensive overview recent accomplishments, remaining challenges, future microneedle-facilitated therapy afflictions.

Language: Английский

Citations

18
Modelling and numerical simulations of eco-friendly double absorber solar cell “Spiro-OmeTAD/CIGS/MASnI3/CdS/ZnO” and its PV-module DOI
Owais Ahmad, Irfan Qasim, Syed M. Hasnain

et al.

Organic Electronics, Journal Year: 2023, Volume and Issue: 117, P. 106781 - 106781

Published: Feb. 28, 2023

Language: Английский

Citations

17
Swellable Microneedles in Drug Delivery and Diagnostics DOI Creative Commons
Hossein Omidian, Sumana Dey Chowdhury

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 791 - 791

Published: June 16, 2024

This manuscript explores the transformative potential of swellable microneedles (MNs) in drug delivery and diagnostics, addressing critical needs medical treatment monitoring. Innovations hydrogel-integrated MN arrays facilitate controlled release, thereby expanding options for chronic diseases conditions that require precise dosage control. The review covers challenges, such as scalability, patient compliance, manufacturing processes, well achievements advanced manufacturing, biocompatibility, versatile applications. Nonetheless, limitations physiological responsiveness long-term stability remain, necessitating further research material innovation integration with digital technologies. Future directions focus on biomedical applications, advancements, regulatory considerations widespread clinical adoption.

Language: Английский

Citations

4
Recent progress in the 3D printing of microneedle patches for biomedical applications DOI
Huan Liu,

Aminov Nail,

Decheng Meng

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124995 - 124995

Published: Nov. 1, 2024

Language: Английский

Citations

4
Recommendations on Intralymphatic Immunotherapy (ILIT): Precision Medicine in Vaccination and Immunotherapy DOI
Pål Johansen

Published: Nov. 22, 2024

Intralymphatic Immunotherapy (ILIT) offers a safe and efficient form of Allergen (AIT) is becoming increasingly important in clinical research off-label use. Since its efficacy depends on precise injections, the lack procedural standards poses challenge to maintaining uniform treatment quality. By analyzing 173 injection videos, we critically evaluated key aspects ILIT method provided set pragmatic recommendations for accurate injections with greater ease consistency. Considering increasing use ILIT, our empirically may provide foundation establishment recognition as valid allergen immunotherapy.

Language: Английский

Citations

0
Advances in Research of Hydrogel Microneedle-Based Delivery Systems for Disease Treatment DOI Creative Commons
Juan Cao, Bo Wu, Ping Yuan

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1571 - 1571

Published: Dec. 9, 2024

Microneedles (MNs), composed of multiple micron-scale needle-like structures attached to a base, offer minimally invasive approach for transdermal drug delivery by penetrating the stratum corneum and delivering therapeutic agents directly epidermis or dermis. Hydrogel microneedles (HMNs) stand out among various MN types due their excellent biocompatibility, high drug-loading capacity, tunable drug-release properties. This review systematically examines matrix materials fabrication methods HMN systems, highlighting advancements in natural synthetic polymers, explores applications treating conditions such as wound healing, hair loss, cardiovascular diseases, cancer. Furthermore, potential HMNs disease diagnostics is discussed. The identifies key challenges, including limited mechanical strength, efficiency, lack standardization, while proposing strategies overcome these issues. With integration intelligent design enhanced control over dosage safety, are poised revolutionize expand personalized medicine.

Language: Английский

Citations

0