Hydrogel
wound
dressings
have
emerged
as
a
promising
solution
for
healing
due
to
their
excellent
mechanical
and
biochemical
properties.
Over
recent
years,
there
has
been
significant
progress
in
expanding
the
variety
of
raw
materials
used
hydrogel
formulation
along
with
development
advanced
modification
techniques
design
approaches
that
enhance
performance.
However,
comprehensive
review
encompassing
diverse
polymer
strategies
innovations
is
still
lacking
literature.
This
summarizes
use
natural
polymers
(e.g.,
chitosan,
gelatin,
sodium
alginate,
hyaluronic
acid,
dextran)
synthetic
poly(vinyl
alcohol),
polyethylene
glycol,
Pluronic
F-127,
poly(N-isopropylacrylamide),
polyacrylamide,
polypeptides)
dressings.
We
further
explore
advantages
limitations
these
discuss
various
strategies,
including
cationic
modification,
oxidative
double-bond
catechol
etc.
The
also
addresses
principles
synthesis
methods,
aligning
modifications
specific
requirements
healing.
Finally,
we
future
challenges
opportunities
hydrogel-based
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 30, 2024
Abstract
Multifunctional
nanoagents
are
robust
to
remodel
environments
for
managing
chronic
diabetic
wounds.
However,
their
delivery
primarily
relies
on
Brownian
motion
and
randomly
enhanced
diffusion.
Here,
taking
advantage
of
wound
heterogeneity,
such
as
the
uneven
distribution
glucose,
hyperglycemia
targeting
nanomotors
proposed.
They
capable
efficiently
hyperglycemic
interfaces
in
wounds
significantly
accelerating
healing
by
employing
endogenous
glucose‐activated
cascade
reactions
responding
local
glucose
gradients.
Compared
previous
counterparts,
they
show
a
four‐fold
enhancement
effective
coverage
within
60
s
multiplied
accumulation
at
interfaces,
facilitating
deep
penetration.
Correspondingly,
downregulation
levels
is
apparently
enhanced,
while
pH‐lowering
oxygen‐supplying
both
improved.
In
comparison
counterparts
delivered
passive
diffusion
diffusion,
nanomotor‐based
spray
accelerates
upon
mice
approximately
30%
23%,
resulting
from
restricted
inflammatory
response,
reactive
oxygen
species
(ROS)
scavenging
elevated
vascular
endothelial
growth
factor
(VEGF).
This
study
presents
generally
efficient
approach
targeted
management
utilizing
which
can
be
extended
other
therapeutic
systems.
ACS Applied Materials & Interfaces,
Journal Year:
2025,
Volume and Issue:
17(6), P. 9115 - 9124
Published: Jan. 30, 2025
Wearable
temperature-sensitive
electronic
skin
enables
robots
to
rapidly
detect
environmental
changes
and
respond
intelligently,
thereby
reducing
temperature-related
mechanical
failures.
Additionally,
this
can
measure
record
the
temperature
of
external
objects,
broadening
its
potential
applications
in
medical
field.
In
study,
we
designed
a
thermally
sensitive
artificial
ionic
using
liquids
(ILs)
as
solvents
carbon
nanotubes
(CNTs)
conductive
fillers.
The
incorporation
ILs
into
polymer
network
enhances
thermal
stability,
while
CNTs
establish
dual
conduction
pathways
(CNTs-CNTs
CNTs-polymer
chain
segments),
leading
rapid
response
times
only
16
s.
initiation
IL
dissociation
at
elevated
temperatures
boosts
carrier
density,
resulting
substantial
improvement
sensitivity
(5%/°C).
Furthermore,
displays
remarkable
self-healing
properties
(90%),
extending
lifespan
practical
applications.
This
kind
stably
sense
wearer's
body
provide
an
ideal
long-term
stable
new
functional
material
for
development
human
such
robots.
