Hydrogel
wound
dressings
have
emerged
as
a
promising
solution
for
healing
due
to
their
excellent
mechanical
and
biochemical
properties.
Over
recent
years,
there
has
been
significant
progress
in
expanding
the
variety
of
raw
materials
used
hydrogel
formulation
along
with
development
advanced
modification
techniques
design
approaches
that
enhance
performance.
However,
comprehensive
review
encompassing
diverse
polymer
strategies
innovations
is
still
lacking
literature.
This
summarizes
use
natural
polymers
(e.g.,
chitosan,
gelatin,
sodium
alginate,
hyaluronic
acid,
dextran)
synthetic
poly(vinyl
alcohol),
polyethylene
glycol,
Pluronic
F-127,
poly(N-isopropylacrylamide),
polyacrylamide,
polypeptides)
dressings.
We
further
explore
advantages
limitations
these
discuss
various
strategies,
including
cationic
modification,
oxidative
double-bond
catechol
etc.
The
also
addresses
principles
synthesis
methods,
aligning
modifications
specific
requirements
healing.
Finally,
we
future
challenges
opportunities
hydrogel-based
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 26, 2025
Fullerene-based
nanoparticles
have
been
extensively
developed
and
applied
in
biological
immunotherapy
due
to
their
unique
immunomodulatory
properties.
However,
current
methods
for
investigating
biodistribution
predominantly
rely
on
fluorescent
labeling,
which
limits
our
understanding
of
the
true
fullerenes
at
both
organ
suborgan
levels,
as
well
impact
organ-specific
metabolism.
In
this
study,
we
utilized
laser
desorption
ionization
matrix-assisted
desorption/ionization
mass
spectrometry
imaging
achieve
simultaneous
vivo
mapping
associated
metabolites.
Following
tail-vein
injection
into
mice,
were
primarily
localized
liver
spleen
with
significant
enrichment
red
pulp
spleen.
Notably,
fullerene
accumulation
normal
tissues
resulted
substantial
alterations
endogenous
metabolic
pathways,
particularly
those
related
pyrimidine,
purine,
energy
This
approach
provides
valuable
insights
effects
vivo,
offering
a
foundation
further
investigation
therapeutic
implications.
Hydrogel
wound
dressings
have
emerged
as
a
promising
solution
for
healing
due
to
their
excellent
mechanical
and
biochemical
properties.
Over
recent
years,
there
has
been
significant
progress
in
expanding
the
variety
of
raw
materials
used
hydrogel
formulation
along
with
development
advanced
modification
techniques
design
approaches
that
enhance
performance.
However,
comprehensive
review
encompassing
diverse
polymer
strategies
innovations
is
still
lacking
literature.
This
summarizes
use
natural
polymers
(e.g.,
chitosan,
gelatin,
sodium
alginate,
hyaluronic
acid,
dextran)
synthetic
poly(vinyl
alcohol),
polyethylene
glycol,
Pluronic
F-127,
poly(N-isopropylacrylamide),
polyacrylamide,
polypeptides)
dressings.
We
further
explore
advantages
limitations
these
discuss
various
strategies,
including
cationic
modification,
oxidative
double-bond
catechol
etc.
The
also
addresses
principles
synthesis
methods,
aligning
modifications
specific
requirements
healing.
Finally,
we
future
challenges
opportunities
hydrogel-based
