Ceramics International, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(11), P. 7015 - 7057
Published: Oct. 18, 2024
Biomedical polymers play a key role in preventing, diagnosing, and treating diseases, showcasing wide range of applications. Their unique advantages, such as rich source, good biocompatibility, excellent modifiability, make them ideal biomaterials for drug delivery, biomedical imaging, tissue engineering. However, conventional suffer from poor degradation
Language: Английский
Citations
6
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(12), P. 5106 - 5131
Published: Nov. 2, 2024
Reactive oxygen species (ROS)-responsive drug delivery systems (DDSs) have garnered significant attention in cancer research because of their potential for precise spatiotemporal release tailored to high ROS levels within tumors. Despite the challenges posed by distribution heterogeneity and endogenous supply constraints, this review highlights strategic alliance ROS-responsive DDSs with photodynamic therapy (PDT), enabling selective leveraging PDT-induced enhanced therapeutic efficacy. This delves into biological importance progression treatment. We elucidate detail operational mechanisms linkers, including thioether, thioketal, selenide, diselencide, telluride aryl boronic acids/esters, as well latest developments nanomedicines that integrate PDT strategies. These insights are intended inspire design innovative nanocarriers PDT.
Language: Английский
Citations
6
Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 19, 2025
Using electrochemically responsive metal-organic frameworks (MOFs) as host matrices to afford gating properties for functional guests is rather attractive but remains unexplored. Herein, a series of functionalized Zr-MOFs with viologen-like skeletons were created by engineering 2,2'-bipyridinium bay substitution different alkyl chains. Of the series, benefiting from enhanced rigidity, one bearing N,N'-ethylene bridge, UiO-67-EE, exhibited strongest electron deficiency due lowest LUMO level, thereby leading efficient transfer and favorable redox activity, which further endowed it outstanding electrochromic properties. More importantly, highly electron-deficient framework UiO-67-EE could allow accommodation electron-rich guest molecules through host-guest charge (CT) interactions. By leveraging electroresponsiveness functionality, served an adaptable platform controlled release capture control dynamic CT interactions upon stimuli alternate potentials. This smart electrochemical behavior systems was also monitored in real time distinguishable optical changes guests. Besides, exploited develop high-performance sensing platforms integrating molecular gate constructed target-aptamer complex.
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
Abstract Antibiotic therapy is a key strategy for treating infections associated with orthopedic implants, yet its limited effectiveness and potential to disrupt bone healing highlight the need innovative approaches. Herein, TiO 2 ‐Graphene (TiO ‐G) metastructure developed on Ti implant surface using hydrothermal method coupled plasma‐enhanced chemical vapor deposition (PECVD), showing strong near‐infrared light (NIR) absorption. The antibiotic doxycycline (DOX) successfully loaded onto ‐G exhibited enhanced NIR release. promising antibacterial efficacy proven by both in vitro vivo tests irradiation 5 min, which ascribed synergistic photocatalytic activity of NIR‐responsive release DOX. Interestingly, after min irradiation, metasurface neutralized immediate negative effects photodynamics even upregulated expression osteogenic genes (osteocalcin (OPN), osteopontin (BSP), sialoprotein (OCN)), particularly observed day 14. Moreover, sustained function significantly mitigated cytotoxicity free antibiotics capabilities comparable those ‐G/DOX under min. Consequently, studies proved that osteointegration absence infection when
Language: Английский
Citations
0
Applied Physics Reviews, Journal Year: 2024, Volume and Issue: 11(3)
Published: July 19, 2024
Real-time health monitoring and precision treatment are important in the biomedical field. Researchers have focused on unique gadgets with peculiar functions, which emerged from merging of electronic components biological systems. Because implantable bioelectronics can sense bodily information or elicit reactions living creatures sites outside body, they becoming helpful promising remedies for a variety ailments. Carbon materials more suitable than other manufacture medical electronics due to their excellent biocompatibility, fatigue resistance, low specific gravity. Therefore, carbon apply wide range drug delivery devices, biosensors, therapeutic stimulators, energy storage play irreplaceable roles neurological, cardiovascular, gastrointestinal, locomotor systems, among others. This review aims offer researchers insight into carbon-based Initially, various types were introduced. Subsequently, it delves four perspectives: actuators, power supplies. Furthermore, we anticipate future direction potential applications bioelectronics. Given evolving field nanotechnology bioelectronics, optimistic that these devices will foster significant breakthroughs innovations sector. Ultimately, this assist navigating choices directions thereby promoting advancement contributing positively welfare humankind.
Language: Английский
Citations
3
Epiliepsy currents/Epilepsy currents, Journal Year: 2025, Volume and Issue: unknown
Published: March 25, 2025
Multifunctional hydrogel electronics for closed-loop antiepileptic treatment Qu J., Xie K., Chen S., He X., Wang Y., Chamberlin M., Zhao Zhu G., Xu C., Shi P. Sci Adv . 2024;10,(47):eadq9207. Closed-loop strategies offer advanced therapeutic potential through intelligent disease management. Here, we develop a hydrogel-based, single-component, organic electronic device neurotherapy. Fabricated out of conductive hydrogels, the consists flexible array microneedle electrodes, each which can be individually addressed to perform electrical recording and control chemical release with sophisticated spatiotemporal control, thus pioneering smart antiseizure system by combining pharmacological interventions. The recorded neural signal acts as trigger voltage-driven drug in detected pathological conditions predicted real-time electrophysiology analysis. When implanted into epileptic animals, enables autonomous management, where dosing is controlled time-sensitive, region-selective, dose-adaptive manner, allowing inhibition seizure outbursts delivery just-necessary dosages. side effects are minimized dosages three orders magnitude lower than usage approaches simulating existing clinical treatments.
Language: Английский
Citations
0
Published: April 1, 2025
Language: Английский
Citations
0
eScience, Journal Year: 2025, Volume and Issue: unknown, P. 100409 - 100409
Published: April 1, 2025
Language: Английский
Citations
0
Nano Energy, Journal Year: 2025, Volume and Issue: unknown, P. 111119 - 111119
Published: May 1, 2025
Language: Английский
Citations
0
Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
1