bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 30, 2024
ABSTRACT
Interest
in
utilizing
amyloids
to
develop
biomaterials
is
increasing
due
their
potential
for
biocompatibility,
unique
assembling
morphology,
mechanical
stability,
and
biophysical
properties.
However,
challenges
include
the
complexity
of
peptide
chemistry
practical
techniques
required
processing
into
bulk
materials.
In
this
work,
two
decapeptides
with
fibrillar
globular
morphologies
were
selected,
blended
poly(ethylene
oxide),
fabricated
composite
mats
via
electrospinning.
Notable
enhancements
properties
observed,
attributed
uniform
distribution
decapeptide
assemblies
within
PEO
matrix.
Morphological
differences,
such
as
production
thinner
nanofibers,
are
increased
conductivity
from
zwitterionic
nature
decapeptides.
Blend
rheology
post-processing
analysis
revealed
how
might
affect
amyloid
aggregation
secondary
structure
peptides.
Both
demonstrated
good
biocompatibility
strong
antioxidant
activity,
indicating
safe
effective
use
biomaterials.
By
evaluating
these
interdependencies,
research
lays
foundation
understanding
structure-property-processing
relationships
peptide-polymer
blends
highlights
developing
applications
biotechnology.
