Antibiotic
resistance
in
bacterial
pathogens
is
a
global
health
problem
requiring
enormous
research
into
alternative,
easily
accessible
antibacterial
substances
and
treatments
to
replace
antibiotics.
Components
of
essential
oils
(EOs)
that
possess
broad-spectrum
properties
are
promising
candidates.
However,
due
their
high
volatility
low
solubility,
administration
remains
difficult.
A
method
load
materials
with
the
active
component
design
triggered
release
system
avoid
rapid
exhaustion
carried
material.
If
such
drug-release
would
additionally
exhibit
itself,
it
could
significantly
advance
combatting
infections.
Therefore,
present
study,
we
combine
light-triggered
simultaneous
antimicrobial
substance
thymol
photodynamic
therapy
(aPDT)
within
one
nanoparticle.
The
irradiation
an
immobilized
photosensitizer
produces
reactive
oxygen
species
(ROS)
oxidatively
cleave
linker
ultimately
releases
detected
by
GC-MS.
Antibacterial
towards
Staphylococcus
aureus
biofilm
formation
were
verified
ATP-based
viability
assay.
To
improve
application
for
deep
tissue
delivery,
also
take
account
transmittance
visible
light.
highly
developed
trifunctional
material
enables
2-photon
excitation
via
Förster
resonance
energy
transfer
(FRET)
thus
shifts
wavelength
biological
window.
third
functionality
can
be
monitored
situ
fluorescence
microscopy.
This
model
lays
foundation
future
Molecular Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 9, 2025
To
enhance
the
therapeutic
efficacy
and
safety
of
triple-negative
breast
cancer
(TNBC)
treatment,
we
developed
a
hypoxia-responsive
drug
delivery
system
utilizing
digoxin
(DIG)
to
inhibit
HIF-1α
sensitize
TNBC
doxorubicin
(DOX).
DIG,
cardiac
steroid
with
well-characterized
pharmacological
mechanism,
was
encapsulated
in
micelles
composed
methoxy-polyethylene
glycol
(mPEG)
poly(lactic
acid)
(PLA)
copolymers,
incorporating
an
azobenzene
(AZO)
trigger
for
hypoxia-sensitive
release.
The
loading
ratio
DOX
DIG
optimized
based
on
DIG's
minimum
effective
dose.
In
vitro
vivo
studies
demonstrated
that
efficiently
delivered
their
payload
hypoxic
tumor
regions,
enabling
rapid
DIG-mediated
inhibition
enhanced
sensitivity
DOX,
leading
significant
suppression
both
primary
growth
pulmonary
metastasis.
This
study
presents
promising
clinically
feasible
strategy
other
hypoxia-driven
malignancies.
Journal of Controlled Release,
Journal Year:
2025,
Volume and Issue:
unknown, P. 113652 - 113652
Published: March 1, 2025
Cell-particle
interactions,
such
as
phagocytosis,
exhibit
variability
based
on
particle
shape,
surface
physical
properties,
and
diameter.
These
interactions
can
be
intentionally
modified
through
in
situ
change
the
characteristics
of
particulate
materials.
By
manipulating
both
properties
shape
particles,
it
may
feasible
to
regulate
their
with
cells.
Objective
this
research
is
prepare
thermoresponsive
core-corona
particles
those
undergo
transformation
alteration
solubility
near
physiological
temperature
investigate
shape-
property-dependent
phagocytosis.
The
glass
transition
prepared
was
controlled
via
composition
polymer
core.
Rod-type
by
uniaxially
stretching
particle-containing
films
at
above
core-forming
materials,
demonstrated
reduced
phagocytosis
macrophages
compared
that
spherical
particles.
Furthermore,
exerted
a
significant
influence
hydrophobic
being
more
readily
engulfed.
Consequently,
precise
control
particle's
properties.
have
potential
applications
drug
delivery
system
carriers,
enabling
regulation
cell
induced
changes.
BIO Integration,
Journal Year:
2025,
Volume and Issue:
6(1)
Published: Jan. 1, 2025
Pulmonary
fibrosis
(PF)
is
a
progressive
interstitial
lung
disease
characterized
by
excessive
extracellular
matrix
deposition
and
tissue
scarring,
leading
to
impaired
function
respiratory
failure.
Although
current
treatments,
such
as
pirfenidone
nintedanib,
slow
progression,
they
fail
completely
halt
or
reverse
fibrosis.
Therefore,
innovative
therapeutic
strategies
are
needed.
Targeted
drug
delivery
systems
(TDDSs)
emerging
promising
solutions.
Biomaterials
play
critical
roles
in
these
enhancing
specificity,
availability,
efficacy,
while
minimizing
systemic
toxicity.
The
most
notable
biomaterials
include
nanotechnology-based
systems,
including
liposomes
polymeric
nanoparticles,
which
facilitate
penetration
release
fibrotic
tissues.
Hydrogels
have
three-dimensional
structures
providing
controlled
sustained
at
inflammation
sites,
therefore
particularly
valuable
PF
treatment.
Furthermore,
biological
carriers
stem
cells
vesicles
biocompatibility
anti-inflammatory
effects
that
improve
outcomes.
Despite
the
potential
of
clinical
translation
hindered
several
challenges,
immune
clearance,
stability
platforms,
optimization
retention
within
diseased
Interdisciplinary
approaches
integrating
precision
medicine
with
advancements
may
provide
solutions
opening
new
avenues
for
This
review
discusses
developments
targeted
PF,
emphasizing
importance
biomaterials,
mechanisms
barriers
involved
pulmonary
delivery,
future
perspectives
overcoming
limitations.
ultimate
goal
patient
outcomes
revolutionizing
approach
treatment
through
advanced
technologies.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Sept. 16, 2024
Systemic
infection
with
Candida
albicans
poses
a
significant
risk
for
people
weakened
immune
systems
and
carries
mortality
rate
of
up
to
60%.
However,
current
therapeutic
options
have
several
limitations,
including
increasing
drug
tolerance,
notable
off-target
effects,
severe
adverse
reactions.
Over
the
past
four
decades,
progress
in
developing
drugs
treat
infections
has
been
sluggish.
This
comprehensive
review
addresses
limitations
existing
summarizes
efforts
made
toward
redesigning
innovating
or
novel
through
nanotechnology.
The
discussion
explores
potential
applications
nanomedicine
from
perspectives:
nano-preparations
anti-biofilm
therapy,
innovative
formulations
"old
drugs"
targeting
cell
membrane
wall,
reverse
resistance
therapy
subcellular
organelles,
virulence
deprivation
leveraging
unique
polymorphism
albicans.
These
approaches
are
promising
address
above
challenges
enhance
efficiency
development
infections.
By
harnessing
nano-preparation
technology
transform
preclinical
drugs,
targets
will
be
uncovered,
providing
effective
solutions
broader
horizons
improve
patient
survival
rates.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 22, 2025
Abstract
Epigenetic
dysregulation
is
prevalent
in
human
cancers,
affecting
gene
expression
and
metabolic
patterns
to
meet
the
demands
of
malignant
evolution
abnormal
epigenetic
processes,
resulting
a
protumor
immune
microenvironment.
Tumors
require
steady
supply
methionine
for
maintaining
flexibility,
which
only
exogenous
precursor
methyl
donor
S‐adenosylmethionine
methylation,
crucial
their
resistance
therapies
survival
nutrient‐deficient
Thus,
tumor
cells
upregulate
Lat4
transporter
compete
deprive
microenvironment,
sustaining
phenotypes
also
impairing
cell
functions.
Addressing
this
addiction
key
overcoming
drug
improving
response.
Despite
challenge
lacking
specific
inhibitors,
an
oxaliplatin
prodrug
crosslinked
fluorinated
polycation/anti‐Lat4
small
interfering
RNA
complex
nanoregulator
(AS‐F‐NP)
has
been
designed
developed
here.
This
restricted
greedy
uptake
by
knocking
down
Lat4,
turn
inhibited
while
restoring
viability
function
tumor‐infiltrating
cells.
Biomacromolecules,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 7, 2025
This
work
reports
the
development
and
evaluation
of
dendrimer-based
nanogels
based
on
polyamidoamine
(PAMAM)
dendrimer
generation
5,
engineered
to
act
as
a
carrier
with
reactive
oxygen
species
(ROS)-scavenging
capabilities.
We
developed
cross-linking
reaction-enabled
flash
nanoprecipitation
method
in
which
reaction
occurs
during
process
form
cross-linked
nanostructure.
Using
this
approach,
an
N-hydroxysuccinimide
(NHS)-functionalized
ROS-responsive
thioketal
cross-linker
(TK-NHS)
was
synthesized
utilized
cross-link
DAB-core
PAMAM
G5,
resulting
formation
G5-TK
nanogels.
The
were
characterized
using
dynamic
light
scattering
transmission
electron
microscopy,
their
cytocompatibility,
irritancy,
cellular
uptake,
ROS
scavenging
activity
assessed.
confirmed
capability
these
observed
favorable
safety
profiles.
can
be
further
carriers
for
therapeutic
delivery
applications
treat
oxidative
stress-related
pathological
conditions.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 8, 2025
Abstract
In
recent
years,
nanomaterials
have
demonstrated
broad
prospects
in
the
diagnosis
and
treatment
of
retinal
diseases
due
to
their
unique
physicochemical
properties,
such
as
small‐size
effects,
high
biocompatibility,
functional
surfaces.
Retinal
are
often
accompanied
by
complex
pathological
microenvironments,
where
conventional
diagnostic
therapeutic
approaches
face
challenges
low
drug
delivery
efficiency,
risks
associated
with
invasive
procedures,
difficulties
real‐time
monitoring.
Nanomaterials
hold
promise
addressing
these
limitations
traditional
therapies,
thereby
improving
precision
efficacy.
The
applications
diagnostics
summarized,
they
enable
high‐resolution
imaging
carrying
fluorescent
probes
or
contrast
agents
act
biosensors
sensitively
detect
disease‐related
biomarkers,
facilitating
early
dynamic
therapeutics,
functionalized
nanocarriers
can
precisely
deliver
drugs,
genes,
antioxidant
molecules
target
cells,
significantly
enhancing
outcomes
while
reducing
systemic
toxicity.
Additionally,
nanofiber
materials
possess
properties
that
make
them
particularly
suitable
for
regeneration
tissue
engineering.
By
loading
neurotrophic
factors
into
scaffolds,
regenerative
effects
be
amplified,
promoting
repair
neurons.
Despite
immense
potential,
clinical
translation
still
requires
long‐term
biosafety,
scalable
manufacturing
processes,
optimization
targeting
efficiency.
