Bioinspired micro‐ and nanostructured systems for cancer therapy DOI Creative Commons
Ruizhen Yang, Bing Zhang,

Xiawei Fei

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 28, 2024

Abstract Numerous organisms in nature have demonstrated enhanced biocompatibility, precise tumor targeting capabilities, and efficient tissue traversal within the human body. Drawing inspiration from these organisms, researchers employed bioengineering, bioconjugation, micro‐ or nanotechnology to fabricate bioinspired nanostructured systems. These systems play a crucial role addressing limitations of conventional anticancer drugs nanomaterials concerning effective penetration physiological barriers, as well selective targeting, thereby leading improved therapeutic efficacy while minimizing nonspecific adverse effects on healthy cells. Consequently, extensive exploration has been undertaken across various cancer treatment modalities with some progressing into preclinical clinical stages. However, our understanding this field remains limited which may impede research progress, translation efforts, practical applications. Therefore, study presents systematic classification for therapy that comprehensively elucidates their sources design principles. Furthermore, it extensively discusses current status efforts identifying prevailing challenges exploring future prospects. This work will establish robust theoretical framework serve valuable reference facilitate advancements application field.

Language: Английский

Metabolic reprogramming and therapeutic resistance in primary and metastatic breast cancer DOI Creative Commons
Shan Liu,

Xingda Zhang,

Wenzheng Wang

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 21, 2024

Metabolic alterations, a hallmark of cancer, enable tumor cells to adapt their environment by modulating glucose, lipid, and amino acid metabolism, which fuels rapid growth contributes treatment resistance. In primary breast metabolic shifts such as the Warburg effect enhanced lipid synthesis are closely linked chemotherapy failure. Similarly, metastatic lesions often display distinct profiles that not only sustain but also confer resistance targeted therapies immunotherapies. The review emphasizes two major aspects: mechanisms driving in both how unique environments sites further complicate treatment. By targeting vulnerabilities at stages, new strategies could improve efficacy existing provide better outcomes for cancer patients.

Language: Английский

Citations

16
Precision tumor treatment utilizing bacteria: principles and future perspectives DOI Creative Commons

Zhaoyou Liu,

Lantian Wang,

Pengying Wu

et al.

Applied Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 109(1)

Published: Jan. 4, 2025

Bacteria-based tumor therapy, which releases therapeutic payloads or remodels the tumor's immune-suppressive microenvironment and directly kills cells initiates an anti-tumor immune response, is recently recognized as a promising strategy. Bacteria could be endowed with capacities of targeting, cell killing, activating by established gene engineering. Furthermore, integration synthetic biology nanomedicine into these engineered bacteria further enhance their efficacy controllability. This comprehensive review systematically elucidates classification mechanisms bacterial expression induction systems, well strategies for constructing bacterial-nanomaterial nanobiohybrids. The concludes highlighting challenges associated quality control regulation bacteria-based therapy while also providing insights future prospects this technology. • A overview current status research on therapy. systems are summarized. perspectives in clinical translation.

Language: Английский

Citations

1
Engineered bacterial membrane biomimetic covalent organic framework as nano-immunopotentiator for cancer immunotherapy DOI

Qi‐Chao Yang,

Yuanyuan Wang, Shuo Wang

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 47, P. 283 - 294

Published: Jan. 25, 2025

Language: Английский

Citations

1
Intratumoral Microbiota as a Target for Advanced Cancer Therapeutics DOI
Fei Peng, Mengyuan Hu, Zhiyue Su

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(38)

Published: July 26, 2024

Abstract In recent years, advancements in microbial sequencing technology have sparked an increasing interest the bacteria residing within solid tumors and its distribution functions various tumors. Intratumoral critically modulate tumor oncogenesis development through DNA damage induction, chronic inflammation, epigenetic alterations, metabolic immune regulation, while also influencing cancer treatment efficacy by affecting drug metabolism. response to these discoveries, a variety of anti‐cancer therapies targeting microorganisms emerged. These approaches encompass oncolytic therapy utilizing tumor‐associated bacteria, design biomaterials based on intratumoral use bacterial components for delivery systems, comprehensive strategies aimed at eradication tumor‐promoting bacteria. Herein, this review article summarizes patterns different tumors, examines their impact evaluates current therapeutic centered Furthermore, challenges prospects developing drugs that target communities are explored, promising new directions treatment.

Language: Английский

Citations

5
Synthetic Gene Circuits as a Promising Approach in Cancer Immunotherapy DOI

Bhanuprakash Ananthakumar,

Nagashri Nanjundeshwara,

Archana Lakshmaiah

et al.

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 391 - 418

Published: Aug. 28, 2024

Cancer immunotherapy has emerged as a revolutionary approach in the fight against cancer. Unlike traditional treatments like chemotherapy and radiation, harnesses power of body's own immune system to identify destroy cancer cells. promising therapy, but limitations specificity control hinder its full potential. Synthetic gene circuits offer address these challenges. This chapter emphasizes diverse applications synthetic immunotherapy. Additionally, authors discuss advantages AND gate for minimizing off-target effects, engineered bacteria targeted tumour manipulation, T-cell engineering enhanced anti-tumour activity. Ultimately, therapies are not mutually exclusive. While proven effectiveness accessibility, hold immense promise personalized, long-term solutions.

Language: Английский

Citations

5
Lactate/Cysteine Dual-Consuming Probiotic–Nanomedicine Biohybrid System for Enhanced Cancer Chemo-Immunotherapy DOI

Tian‐Qiu Xie,

Xiao Yan,

You‐Teng Qin

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(50), P. 16132 - 16142

Published: Dec. 6, 2024

Immunotherapy is revolutionizing oncology, but its therapeutic efficiency still limited by the off-target toxicities and poor antitumor immune responses. By integrating drug-loaded nanoparticles (DMnSH) with unique metabolic traits of Veillonella parvula (Vei), a probiotic–nanomedicine conjugate Vei@DMnSH biohybrid elaborately designed for enhanced cancer chemo-immunotherapy. Specifically, can accumulate in hypoxic tumor sites simultaneously consume lactate cysteine to reverse lactate-associated immunosuppression impede biosynthesis GSH. In addition, DMnSH will rapidly deplete intracellular GSH disassemble release DOX Mn2+. Accompanied two-pronged depletion, Mn2+-mediated Fenton-like reaction effectively generate oxidative hydroxyl radicals induce heavy redox imbalance. Combined effect DOX, robust immunogenic cell death provoked subsequently activates adaptive immunity suppression rate over 82%, synergistically enhancing outcomes

Language: Английский

Citations

5
Smart Bioorthogonal Nanozymes: From Rational Design to Appropriate Bioapplications DOI
Bin Zhang, Jiawei Zhu, Jinsong Ren

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(41)

Published: Aug. 16, 2024

Abstract Bioorthogonal chemistry has provided an elaborate arsenal to manipulate native biological processes in living systems. As the great advancement of nanotechnology recent years, bioorthogonal nanozymes are innovated tackle challenges that emerged practical biomedical applications. uniquely positioned owing their advantages high customizability and tunability, as well good adaptability systems, which bring exciting opportunities for More intriguingly, offers opportunity innovating catalytic materials. In this comprehensive review, significant progresses discussed with both spatiotemporal controllability performance highlight design principles rapid The remaining future perspectives then outlined along thriving field. It is expected review will inspire promote novel nanozymes, facilitate clinical translation.

Language: Английский

Citations

4
Ultrasound-Energized OX40L-Expressing Biohybrid for Multidimensional Mobilization of Sustained T Cell-Mediated Antitumor Immunity and Potent Sono-Immunotherapy DOI

Mengyun Liang,

Xiaoying Kang,

Hanwen Liu

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Harnessing immunostimulation to reinvigorate antitumor effector immune cells represents a promising strategy for tumor eradication. However, achieving durable clinical outcomes necessitates multidimensional activation sustain robust responses. Here, we present an ultrasound-empowered living biohybrid that strategically mobilizes T-cell-mediated immunity potent sono-immunotherapy. Through synthetic biology, engineer bacteria express fusion protein encoding the costimulatory OX40 ligand (OX40L), and further functionalize them with high-performance polymer sonosensitizer tethered via reactive oxygen species-cleavable linker. Upon ultrasound irradiation, sono-activated nanocargoes detach from bacterial surface, facilitating cellular entry exposing immune-stimulating OX40L. The sonodynamic effects, coupled native immunogenicity of bacteria, promotes tumor-associated antigen release, fosters proinflammatory microenvironment, drives dendritic cell maturation, thereby priming cytotoxic T-cell activation. OX40L expressed by engineered amplifies sustains activity, orchestrating response. This cascade-amplified effectively suppresses growth, induces long-lasting memory, provides protection against metastasis recurrence, significantly enhancing survival outcomes. By integrating ultrasound-energized nanoadjuvants boosters, this hybrid biotherapeutic platform offers versatile powerful activation, advancing frontier cancer

Language: Английский

Citations

0
Preclinical Assessment of Living Therapeutic Materials: State-of-Art and Challenges DOI Creative Commons

Krupansh Desai,

Joëlle Mekontso,

Ketaki Deshpande

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Living Therapeutic Materials represent a promising technology to tackle therapeutic problems that classical materials cannot address. Despite the advancements on new functions of these devices, applications, and fabrication methods, preclinical evaluation is still very limited challenges appear when incorporating living devices in contact with host. This critical bottleneck path translation clinic. Therefore, we have compiled literature Materials, focus microorganism-based materials, summarized investigations carried out assess their biocompatibility, safety, efficacy. We split three parts: vitro, ex vivo, vivo assessments, where describe common practices remaining challenges.

Language: Английский

Citations

0
Bacteria‐Mediated Bismuth‐Based Nanoparticles Activate Toll‐Like Receptors for Breast Cancer Photothermal Immunotherapy DOI

Susu Xiao,

Chenqian Feng,

Min Mu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Abstract One of the latest immunotherapeutic strategies involves modulating tumor microenvironment through Toll‐like receptors (TLRs). However, receptor agonists may induce severe systemic inflammation. Bif@PBi‐R, a bacterial nanomotor is developed with tumor‐targeting properties in this study. Bismuth‐based nanoparticles loaded R848 (Bi‐R NPs) are bound to anaerobic bifidobacteria via polydopamine adhesion. Bif@PBi‐R designed deliver bismuth‐based carrying specifically area activate anti‐tumor immunotherapy. Bismuth an excellent nanomaterial for photothermal conversion. Therefore, not only enhances efficacy therapy kill cells directly but also boosts immune response its therapeutic effect. Combining 808 nm laser irradiation significantly promoted dendritic cell (DCs) maturation, leading potent In summary, effectively immunotherapy when combined (PTT).

Language: Английский

Citations

3