Polydopamine Decorated Hyaluronic Acid Clusters for Tumor Cell Targeting Combination Therapy via Template Self‐Consumption Methods DOI
Hongrui Zhu,

Daqing Xia,

Huan He

et al.

Macromolecular Rapid Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Abstract Photothermal‐chemodynamic‐chemotherapy (PTT‐CDT‐CT) combination therapy significantly enhances the therapeutic efficacy against tumors. However, synthesizing PTT‐CDT‐CT nanosystems is complex, typically requiring preparation and conjugation of three components into a single carrier. To overcome this challenge, facile template self‐consumption method developed. In approach, hyaluronic acid (HA), recognized for its tumor cell targeting properties, chelates with Cu 2+ to form Cu‐HA, which then transforms CuO 2 @HA cluster templates. These templates self‐consume gradually, producing ·OH , catalyze rapid polymerization dopamine coordinate polydopamine respectively, enhancing photothermal conversion efficiency. After gossypol loading, GPDA@HA clusters are formed, achieving high loading efficiency due π–π stacking between PDA, as well coordination . The effectively internalized by cells through endocytosis, mediating synergistic damage or inhibition intracellular proteins, nucleic acids via PTT, CDT, CT. Crucially, synergism far surpasses those modality. This work introduces new pathway synthesis nanosystems, avoiding conventional different agents, provides insights developing personalized drug therapies efficacy.

Language: Английский

X‐ray controlled release strategy in cancer therapy DOI Creative Commons

Yiling Ruan,

Hongxiang Huang,

Huihui Liu

et al.

BMEMat, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Abstract Construction of drug carriers or prodrugs is a common approach to improve the pharmacokinetics molecular drugs and enhance tumor curative effect. Nanocarriers that can be activated by microenvironment including enzymes, pH, redox status, external stimuli such as ultraviolet, ultrasound, magnetism, are booming. As commonly used clinical theranostic with excellent spatiotemporal controllability deep tissue penetration, X‐ray has attracted much attention an stimulus in recent years. The rapid development nanomaterials radiosensitizers radioluminescents further accelerates construction X‐ray‐responsive nanocarriers. In this review, currently developed release systems cancer therapy summarized focus on controlled design.

Language: Английский

Citations

1
Gas immnuo-nanomedicines fight cancers DOI Open Access
Mengchi Sun, Tianye Wang,

Yinmei Zhu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117595 - 117595

Published: Oct. 31, 2024

Certain gas molecules, including hydrogen (H

Language: Английский

Citations

5
Empowering radiotherapy: Harnessing nanomedicines to enhance radiation response and boost antitumor efficacy DOI

Xiqian Zhuo,

Reyida Aishajiang, Liang Yuan

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 520, P. 216140 - 216140

Published: Aug. 13, 2024

Language: Английский

Citations

3
Potential therapeutic applications of medical gases in cancer treatment DOI Creative Commons
Abbas Al Bazzal, Bassel H. Hoteit, Mariam Chokor

et al.

Medical Gas Research, Journal Year: 2025, Volume and Issue: 15(2), P. 309 - 317

Published: Jan. 18, 2025

Medical gases were primarily used for respiratory therapy and anesthesia, which showed promising potential in the cancer therapy. Several physiological pathological processes affected by key gases, such as oxygen, carbon dioxide, nitric oxide, hydrogen sulfide, monoxide. Oxygen targets shrinking tumor via hyperbaric oxygen therapy, once combined with radiation it enhances its effect. Nitric oxide has both anti- pro-tumor effects depending on level; at high doses, triggers cell death while low doses supports growth. The same concept is applied to sulfide promotes growth enhancing mitochondrial bioenergetics supporting angiogenesis concentrations, concentrations induces sparing normal cells. Furthermore, dioxide helps induce apoptosis improve oxygenation treatments increasing release of from hemoglobin. Moreover, high-dose monoxide gas demonstrated significant reductions vivo supported nanomedicine specialized medicines boost delivery cells availability peroxide. Despite potentials these several challenges remain. Gas should be regulated balance anti-tumor sulfide. effective systems, nanoparticles, developed targeted

Language: Английский

Citations

0
Tumor-targeted near-infrared/ultraviolet-triggered photothermal/gas therapy nanoplatform for effective cancer synergistic therapy DOI
Xiaomei Wu,

Zhongyin Chen,

Jinyu Wang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 249, P. 114530 - 114530

Published: Jan. 20, 2025

Language: Английский

Citations

0
Recent Progress in Radiosensitive Nanomaterials for Radiotherapy-Triggered Drug Release DOI

Renfeng Jiang,

Qiong Fang, Wenjun Liu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Benefiting from the unique properties of ionizing radiation, such as high tissue penetration, spatiotemporal resolution, and clinical relevance compared with other external stimuli, radiotherapy-induced drug release strategies are showing great promise in developing effective personalized cancer treatments. However, requirement doses X-ray irradiation to break chemical bonds for limits application prodrug activation clinics. Recent advances nanomaterials offer a promising approach radiotherapy sensitization well integrating multiple modalities improved therapy outcomes. In particular, catalytic radiosensitization that utilizes electrons energy generated by upon has demonstrated excellent potential enhanced radiotherapy. this Review, we summarize design principles X-ray-responsive controlled release, radiosensitization, recent progress nanoradiosensitizers integration chemotherapy, chemodynamic therapy, photodynamic photothermal gas immunotherapy. Finally, discuss challenges heading toward possible translation. We expect emerging based on radiotherapy-triggered will facilitate frontier accurate near future.

Language: Английский

Citations

0
Generalizable Organic-to-Aqueous Phase Transfer of a Au18 Nanocluster with Luminescence Enhancement and Robust Photocatalysis in Water DOI Creative Commons
Zhongyu Liu, Yitong Wang, Weijie Ji

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

For the majority of gold nanoclusters (NCs), their water insolubility, low photoluminescence (PL) intensity, and less understood photostability are three critical factors that limit application in biomedical photocatalysis fields. In this study, we report a polymer wrapping method for phase transfer organic soluble NCs into aqueous without degrading electronic optical properties, such materials further demonstrated robust water. We first synthesized Au18(DMBT)14 NC (DMBT = 2,4-dimethylbenzenethiolate) found aromatic ligands confer greatly enhanced antioxidation capability compared to Au18(CHT)14 counterpart (CHT cyclohexanethiolate), with role ligand interactions identified by X-ray crystallography. The was successfully transferred an amphiphilic (Pluronic F127, abbrev. F127) method, producing Au18-D@F127 nanoparticles [each containing few NCs; Au18-D is abbreviation Au18(DMBT)14] 10-fold enhancement PL similar results were also obtained Au18(CHT)14. This broadly applicable various NCs, rendering solubility significantly enhancing intensity otherwise weakly emissive NCs. exceptional stability enables NPs photocatalytic activation persulfate ions subsequent photodegradation pollutants efficiently.

Language: Английский

Citations

0
Synchrotron‐Based X‐Ray Molecular Probes for Imaging in Intelligent Biomedicine DOI
Dapeng Yin, Yubo Liu, Yu Zhang

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Abstract With the construction and operational launch of third‐generation synchrotron radiation sources, X‐ray molecular probe technology is actively explored developed, playing an increasingly significant role in modern life sciences. This review provides overview synchrotron‐based imaging techniques emphasizes applications probes across various fields associated with intelligent biomedicine. Building on this foundation, it further discusses future advancements forecasts their application trends biomedicine, particularly realm personalized treatment.

Language: Английский

Citations

0
Recent advances and challenges in metal-based antimicrobial materials: a review of strategies to combat antibiotic resistance DOI Creative Commons
Chuanda Zhu,

Zhenli Diao,

Yuanyuan Yang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 9, 2025

Despite the availability of a series classical antibiotic drugs, bacterial infections continue to represent significant and urgent threat global human health. The emergence drug-resistant bacteria slow pace development have rendered current treatment methods inadequate in meeting clinical demands infections. Consequently, there is an increasingly vital need for safe, efficient, alternative novel antimicrobial agents medical healthcare field. Over past five years, has been notable expansion field nanomedicine with regard prevention control infectious diseases. objective this article provide comprehensive review latest research developments metal nanomaterials therapy. We begin by delineating gravity infection crisis, subsequently undertaking examination potential mechanisms through which nanoparticles may combat specific applications these diverse In conclusion, we eagerly anticipate future directions believe that continuous technological advancements innovations, will make even more outstanding contributions safeguarding health well-being.

Language: Английский

Citations

0
Janus Nanoprobe with Dual-Modal NIR-II Fluorescence/Photoacoustic Imaging for Precision Cancer Radiosensitizing Therapy DOI
Shiyu Wang,

Wenzheng Liu,

Yixi Cao

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 10, 2025

The use of radiotherapy sensitizers has proven to be effective in overcoming tumor resistance and improving treatment efficacy. However, challenges such as poor biocompatibility difficulty accurately guiding with high efficiency still persist. Herein, we propose a radiosensitizer Janus nanostructure address these issues by enabling dual-modal fluorescence (FL)/photoacoustic (PA) imaging the second near-infrared region (NIR-II, 900-1700 nm) for precise efficient guidance. nanoprobes are fabricated initially coating silica (SiO2) on one end gold nanorod (AuNR) aspect ratio, followed situ decoration lanthanide-doped down-conversion nanoparticle (DCNP) shell SiO2, finally modifying it biocompatible polyethylene glycol (PEG), named AuNR@DCNP@PEG. Guided NIR-II FL/PA imaging, AuNR@DCNP@PEG was successfully irradiated at optimal enrichment time point, generating significant amount reactive oxygen species exhibiting excellent sensitization effects vitro vivo. This imaging-guided sensitizer is anticipated offer an approach achieving radiotherapy.

Language: Английский

Citations

0