Dual-Enzyme-Instructed Peptide Self-Assembly to Boost Immunogenic Cell Death by Coordinating Intracellular Calcium Overload and Chemotherapy

ACS Nano, Journal Year: 2025, Volume and Issue: 19(1), P. 488 - 503

Published: Jan. 4, 2025

The concept of immunogenic cell death (ICD) induced by chemotherapy as a potential synergistic modality for cancer immunotherapy has been widely discussed. Unfortunately, most chemotherapeutic agents failed to dictate effective ICD responses due their defects in inducing potent signaling. Here, we report dual-enzyme-instructed peptide self-assembly platform CPMC (CPT-GFFpY-PLGVRK-Caps) that cooperatively utilizes camptothecin (CPT) and capsaicin (Caps) promote engage systemic adaptive immunity tumor rejection. Although CPT Caps respectively prevent progression inhibiting type-I DNA topoisomerase activating transient receptor cation channel subfamily V member 1 (TRPV1) intracellular calcium overload, neither alone effectively stimulates sufficient signaling meet immunotherapeutic needs. CPMC, sequentially allowing an active derivative VRK-Caps release extracellularly intracellularly, can synergize two distinct apoptosis pathways stimulated increase immunogenicity elicit T-cell-based immunity. Consequently, facilitates the generation improved tumor-specific cytotoxic T-cell sustained immunological memory, successfully suppressing both primary distant tumors. Moreover, render tumors susceptible PD-L1 blockade with antiprogrammed death-ligand (aPDL1) antibody inhibition. Combining drugs low ICD-stimulating capacity using strategy was demonstrated boost potentiate immunotherapy.

Language: Английский

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Wireless discharge of piezoelectric nanogenerator opens voltage-gated ion channels for calcium overload-mediated tumor treatment

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123311 - 123311

Published: April 1, 2025

Language: Английский

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Nanomaterial‐Mediated Modulation of TRPV1 Ion Channels for Biomedical Applications

Advanced Materials Technologies, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Abstract Transient receptor potential vanilloid subtype 1 (TRPV1) is a nonselective cation channel involved in various physiological processes such as pain perception, thermoregulation, and inflammatory responses. Nanomaterials have emerged precise tools to modulate TRPV1 activity, offering high spatiotemporal resolution specificity. These nanomaterials act transducers, responding internal or external stimuli pH, light, electric, magnetic fields deliver modulatory agents like agonists, antagonists, heat, reactive species, mechanical forces channels. This strategy enables non‐invasive targeted therapeutic interventions for diseases associated with dysfunction. In this review, recent advances are highlighted nanomaterial‐mediated modulation its biomedical applications. The structure activation mechanisms, the integration of effective modulation, required material properties covered. Moreover, applications discussed, including neurostimulation, neurological disorder therapies, cancer metabolic disease treatments, cardiovascular interventions. Future research directions challenges field also proposed.

Language: Английский

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X-ray-Activated Nanoscintillators Integrated with Tumor-Associated Neutrophils Polarization for Improved Radiotherapy in Metastatic Colorectal Cancer

Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 123031 - 123031

Published: Dec. 17, 2024

Language: Английский

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