Supramolecular Architectures of Dendritic Polymers Provide Irreversible Inhibitor to Block Viral Infection DOI Creative Commons
Ehsan Mohammadifar, Matteo Gasbarri,

Mathias Dimde

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 37(3)

Published: Sept. 30, 2024

In Nature, most known objects can perform their functions only when in supramolecular self-assembled from, e.g. protein complexes and cell membranes. Here, a dendritic polymer is presented that inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with an irreversible (virucidal) mechanism into Two-dimmensional (2D-SupraPol). Monomeric analogs of the inhibit SARS-CoV-2 reversibly, thus allowing for virus to regain infectivity after dilution. Upon assembly, 2D-SupraPol shows remarkable half-inhibitory concentration (IC50 30 nM) vitro vivo Syrian Hamster model has good efficacy. Using cryo-TEM, it shown controllable lateral size be tuned by adjusting pH use small angle X-ray neutron scattering unveil architecture assembly. This functional 2D-SupraPol, its are proposed, as prophylaxis nasal spray interaction tract.

Language: Английский

Supramolecular Architectures of Dendritic Polymers Provide Irreversible Inhibitor to Block Viral Infection DOI Creative Commons
Ehsan Mohammadifar, Matteo Gasbarri,

Mathias Dimde

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 37(3)

Published: Sept. 30, 2024

In Nature, most known objects can perform their functions only when in supramolecular self-assembled from, e.g. protein complexes and cell membranes. Here, a dendritic polymer is presented that inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with an irreversible (virucidal) mechanism into Two-dimmensional (2D-SupraPol). Monomeric analogs of the inhibit SARS-CoV-2 reversibly, thus allowing for virus to regain infectivity after dilution. Upon assembly, 2D-SupraPol shows remarkable half-inhibitory concentration (IC50 30 nM) vitro vivo Syrian Hamster model has good efficacy. Using cryo-TEM, it shown controllable lateral size be tuned by adjusting pH use small angle X-ray neutron scattering unveil architecture assembly. This functional 2D-SupraPol, its are proposed, as prophylaxis nasal spray interaction tract.

Language: Английский

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