Single‐Step Synthesis of Sub‐10 nm Magnetic Nanoparticles with High Saturation Magnetization and Broad pH Stability DOI Creative Commons

Vitaly Pustovalov,

Fabian C. Landers,

Lukas Hertle

et al.

Advanced Engineering Materials, Journal Year: 2024, Volume and Issue: 26(20)

Published: Aug. 3, 2024

Iron oxide nanoparticles hold great potential for future biomedical applications but, to date, usually suffer from reduced magnetic properties compared their bulk counterparts. The replacement of Fe(III) ions with Zn(II) can enhance while keeping biocompatibility characteristics. Yet, common synthesis methods these highly particles require using environmentally harmful solvents, multiple steps, and postfunctionalization, all being affected by poor scalability high polydispersity. To address challenges, in this study, a single‐step coprecipitation‐based method is developed fabricate gelatin‐coated, zinc‐substituted, sub‐10 nm‐sized iron exhibiting saturation magnetization. This benefits simplicity robustness, capable yielding large amounts without the utilization or toxic reagents. Furthermore, situ gelatin coating during ensures particle stability aqueous solutions over wide range pH enhances cell compatibility. Systematic investigations show direct correlation between particles’ magnetization concentrations NaOH, where zinc‐to‐iron ratio Zn:Fe = 0.18:2.82 reach maximum 91.2 emu g −1 . Thus, are promising candidates applications.

Language: Английский

Biodegradable Piezoelectric Micro‐ and Nanomaterials for Regenerative Medicine, Targeted Therapy, and Microrobotics DOI Creative Commons
Lorenzo Vannozzi, Carlotta Pucci, Diego Trucco

et al.

Small Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Piezoelectric micro‐ and nanomaterials can generate local electrical signals when subjected to mechanical stress, a phenomenon that be exploited trigger beneficial effects at the cell tissue level. In recent years, research on biodegradable piezoelectric material has gained momentum, as these materials degrade after fulfilling their function. Thus, they promise considerably impact regenerative medicine, targeted therapy, microrobotics, with better chances match regulatory requirements respect nondegradable counterparts. This review offers comprehensive overview of advancements in nanomaterials, focusing mechanisms, types, methods enhance properties. Current characterization techniques, emphasizing both piezoelectricity biodegradability micro/nano scale, are also discussed. Furthermore, it is discussed how use intelligent platforms for medicine responsive drug delivery systems. The application microrobotics examined, particularly potential minimally invasive procedures. Finally, challenges future directions highlighted, underscoring importance versatile advancing biomedical technologies.

Language: Английский

Citations

0
Nanozyme‐Shelled Microcapsules for Targeting Biofilm Infections in Confined Spaces DOI Creative Commons
Hong‐Huy Tran,

Nadasinee Jaruchotiratanasakul,

Zhenting Xiang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

Abstract Bacterial infections in irregular and branched confinements pose significant therapeutic challenges. Despite their high antimicrobial efficacy, enzyme‐mimicking nanoparticles (nanozymes) face difficulties achieving localized catalysis at distant infection sites within confined spaces. Incorporating nanozymes into microrobots enables the delivery of catalytic agents to hard‐to‐reach areas, but poor nanoparticle dispersibility distribution during fabrication hinder performance. To address these challenges, a nanozyme‐shelled microrobotic platform is introduced using magnetic microcapsules with collective adaptive mobility for automated navigation complex confinements. Using double emulsions produced from microfluidics as templates, iron oxide silica are assembled 100‐µm microcapsules, which self‐organize multi‐unit, millimeter‐size assemblies under rotating fields. These exhibit peroxidase‐like activity, efficiently catalyzing hydrogen peroxide generate reactive oxygen species (ROS). Notably, microcapsule display remarkable arched confinements, reaching targeted apical regions tooth canal accuracy. Furthermore, perform rapid situ effectively kill biofilms on contact via ROS generation, enabling antibiofilm action. This study demonstrates facile method integrating onto versatile current needs microenvironments.

Language: Английский

Citations

1
Magneto‐Thermal Hydrogel Swarms for Targeted Lesion Sealing DOI
Ziheng Chen, Hui Chen,

Kaiwen Fang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Abstract Magnetic microswarms capable of performing navigation to targeted lesions show great potential for in vivo medical applications. However, using the swarms lesion cavity filling encounters challenges from precise delivery and sealing. Herein, this work develops a magneto‐thermal hydrogel swarm consisting magnetic particles, which can perform phase transition induced by temperature change. The particles are prepared temperature‐responsive matrix, tissue adhesive monomers, microparticles. be remolded various shapes, it used seal perforation phantom gastric tissue. also serve as drug carriers, their release profiles changes characterized. Finally, delivery, adaptive filling, sealing ulcer achieved ex environments.

Language: Английский

Citations

1
Single‐Step Synthesis of Sub‐10 nm Magnetic Nanoparticles with High Saturation Magnetization and Broad pH Stability DOI Creative Commons

Vitaly Pustovalov,

Fabian C. Landers,

Lukas Hertle

et al.

Advanced Engineering Materials, Journal Year: 2024, Volume and Issue: 26(20)

Published: Aug. 3, 2024

Iron oxide nanoparticles hold great potential for future biomedical applications but, to date, usually suffer from reduced magnetic properties compared their bulk counterparts. The replacement of Fe(III) ions with Zn(II) can enhance while keeping biocompatibility characteristics. Yet, common synthesis methods these highly particles require using environmentally harmful solvents, multiple steps, and postfunctionalization, all being affected by poor scalability high polydispersity. To address challenges, in this study, a single‐step coprecipitation‐based method is developed fabricate gelatin‐coated, zinc‐substituted, sub‐10 nm‐sized iron exhibiting saturation magnetization. This benefits simplicity robustness, capable yielding large amounts without the utilization or toxic reagents. Furthermore, situ gelatin coating during ensures particle stability aqueous solutions over wide range pH enhances cell compatibility. Systematic investigations show direct correlation between particles’ magnetization concentrations NaOH, where zinc‐to‐iron ratio Zn:Fe = 0.18:2.82 reach maximum 91.2 emu g −1 . Thus, are promising candidates applications.

Language: Английский

Citations

0