Recent advances in nanotherapy-based treatment of epilepsy

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 249, P. 114499 - 114499

Published: Jan. 6, 2025

Language: Английский

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Mannose-modified erythrocyte membrane-coated Chuanmingshen violaceum polysaccharide PLGA nanoparticles to improve immune responses in mice

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 152, P. 114450 - 114450

Published: March 12, 2025

Language: Английский

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Imaging Probes for the Detection of Brain Microenvironment

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114677 - 114677

Published: April 1, 2025

Language: Английский

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Smart Organic–Inorganic Copolymer Nanoparticles Distinguish Between Microglia and Cancer Cells for Synergistic Immunotherapy in Glioma

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Abstract The stimulator of interferon genes (STING) pathway has emerged as a new immunotherapy strategy with potent local stimulation specificity, showing promising potential to counteract the immunosuppression in glioma. Herein, tumor microenvironment (TME) responsive nanoagonists are developed based on an organic–inorganic copolymer composed polymer PC6AB coupled manganous phosphate ionic oligomers (MnP). degradation into and MnP acidic TME enables spatiotemporal control their delivery cells immune cells, respectively. membranolytic activity selectively interacts cell membranes induce immunogenic death, while manganese metal can activate STING trigger downstream immunostimulatory signals. Nanoagonists stimulate robust antitumor immunity after injection brain extracellular space (ECS), significant therapeutic efficacy mouse achieve orchestration activation response enhance against “cold” solid tumors, providing approach for clinical immunotherapy.

Language: Английский

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Recent advances in nanoenzymes for Alzheimer's disease treatment

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 244, P. 114139 - 114139

Published: Aug. 8, 2024

Language: Английский

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Breast cancer-targeted therapy and doxorubicin multidrug resistance are reversed via macrophage membrane-camouflaged liposomes

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 245, P. 114310 - 114310

Published: Oct. 9, 2024

Language: Английский

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Stimuli-Responsive Metal–Organic Framework (MOF) Separation Membranes: Constructions and Properties

Industrial & Engineering Chemistry Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

The tunable pore structures and adjustable chemical properties of stimuli-responsive metal–organic frameworks (SRMOFs) provide a powerful platform for designing various membrane materials high performance in separations. This Review mainly emphasizes recent progress on SRMOF membranes gas, ion, liquid In detail, three main construction methods developing these are introduced: responsive unit loading, pendant group functionalization, backbone functionalization. Furthermore, strategies integrating SRMOFs into their separation applications discussed. Finally, the challenges prospects proposed with hope providing insightful guidance next generation smart materials.

Language: Английский

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Nanoparticle Interactions with the Blood Brain Barrier: Insights from Drosophila and Implications for Human Astrocyte Targeted Therapies

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(1)

Published: Jan. 20, 2025

Language: Английский

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Rationally Designed Cell Membrane Biomimetic Biosensing Platform for the Binding Analysis of Drugs with Intracellular Kinase Domain of Epidermal Growth Factor Receptor

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Biosensing technologies have demonstrated significant potential in exploring the binding of drugs to receptor tyrosine kinases (RTKs). As a typical transmembrane receptor, there are still several shortcomings utilization intracellular kinase domain RTKs, primary action site small-molecule inhibitors, resulting insufficient and unclear sites, which impair efficiency accuracy biosensing. Herein, using epidermal growth factor (EGFR) as an example, we reported biosensing platform based on cell membrane camouflage technology for evaluating EGFR. The azide-functionalized membranes modified through glucose metabolism were reverse-coated onto alkyne-functionalized magnetic nanoparticles via bioorthogonal reaction (CMRMNPs), therefore effectively exposing EGFR without damage. To construct platform, fluorescent probe derived from gefitinib pharmacophore (GN probe) was further synthesized incubated with CMRMNPs. This strategy facilitated efficient localization GN within Ultimately, this approach successfully implemented evaluate three inhibitors study provides viable constructing biomimetic biosensors defined orientation offers novel insights methodologies drug regions RTKs.

Language: Английский

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Recent advances in biomimetic nanodelivery systems for the treatment of glioblastoma

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114668 - 114668

Published: March 1, 2025

Language: Английский

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