Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 157802 - 157802
Published: Nov. 1, 2024
Language: Английский
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 19, 2025
Abstract Photosensitizers (PSs) featuring type I reactive oxygen species (ROS) generation and aggregation‐induced emission (AIE) activity offer a promising solution to achieve non‐invasive precise theranostics. However, the reported AIE luminogens (AIEgens) with both characteristic strong type‐I ROS are still scarce structure‐property relationship is unclear. Herein, an innovative acceptor elongation boosted intersystem crossing (AEBIC) design strategy has been proposed endow AIEgen producibility. The results indicate that obtained exhibit aggregation‐enhanced efficacy, which verified by experimental theoretical results. Mechanistic study reveal promoted dual‐channel pathway enhance (ISC) process due differences in triplet configurations, can be further amplified aggregation. afforded AIE‐PS show lipid droplet‐anchored induce ferroptosis through destroying cellular redox homeostasis increasing lethal levels of peroxidation. Finally, targeting ferroptosis‐based cancer therapy realized excellent anti‐tumor effect.
Language: Английский
Citations
0
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 529, P. 216430 - 216430
Published: Jan. 24, 2025
Language: Английский
Citations
0
Advanced Drug Delivery Reviews, Journal Year: 2025, Volume and Issue: 221, P. 115590 - 115590
Published: April 15, 2025
Language: Английский
Citations
0
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 539, P. 216745 - 216745
Published: May 1, 2025
Language: Английский
Citations
0
Biomaterials Research, Journal Year: 2024, Volume and Issue: 28
Published: Jan. 1, 2024
The abnormal tumor vasculature acts as the physical and functional barrier to infiltration activity of effector T cells, leading low response rate immune checkpoint inhibitors (ICIs). Herein, antiangiogenic extracellular vesicles that enable normalization tumor-associated were prepared potentiate efficacy ICIs. Small exploited delivery platform protect protein, pigment epithelium-derived factor (PEDF), from proteolytic degradation. Along with physicochemical characteristics PEDF-enriched (P-EVs), their inhibitory effects on migration, proliferation, tube formation endothelial cells investigated in vitro. In tumor-bearing mice, it was confirmed that, compared bare PEDFs, P-EVs efficiently reduced vessel leakiness, improved blood perfusion, attenuated hypoxia. Consequently, when combined anti-PD-1 antibodies, remarkably augmented antitumor immunity, evidenced by increased CD8 + regulatory cells. These results suggest are promising therapeutics for tumors refractory
Language: Английский
Citations
3
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 501, P. 157763 - 157763
Published: Nov. 17, 2024
Language: Английский
Citations
2
Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 13, 2024
Abstract Photodynamic therapy (PDT) is a promising cancer treatment that uses photosensitizers (PSs) to generate cytotoxic reactive oxygen species (ROS) under light, but improving its efficacy crucial for clinical applications. To address this, we propose smart nanoplatform (P@BAO-DOX) synergistic chemo-photodynamic therapy, featuring efficient PDT, controllable drug release, and fluorescence imaging guidance. We designed an aggregation-induced emission (AIE)-based PS (BAO) with effective ROS generation NIR-II fluorescence. Additionally, BAO as doxorubicin (DOX) chemo were encapsulated in pH-responsive nanogels (PNA) obtain P@BAO-DOX nanogels. Upon uptake by tumor cells, the nanogel releases drugs acidic conditions, leading cell death. White light irradiation further triggers produce substantial ROS, enhancing phototoxicity chemo-PDT therapy. Thus, nanogels, nanoplatform, offer precise release imaging-guided showing promise advancing treatment.
Language: Английский
Citations
1
ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 22, 2024
Triple-negative breast cancer (TNBC) is one of the most aggressive and challenging subtypes with limited treatment options poor prognosis. To overcome these obstacles, Ag-doped SnSe (ASS) nanosheets were used as photonic hyperthermia agents for treating TNBC. ASS featured a high photothermal-conversion efficiency photon effect. Additionally, biosafety assessments, including hemolysis assays histopathological analysis, confirmed that was biosafety. These findings suggest ASS, in synergy second near-infrared biowindow (NIR-II) light irradiation, offers noninvasive, effective, safe therapeutic strategy This innovative approach exemplifies evolving landscape TNBC treatment, where technology biology converge to offer more precise personalized therapies.
Language: Английский
Citations
1
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216236 - 216236
Published: Sept. 25, 2024
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 24, 2024
Abstract Graph theory has been widely used to quantitatively analyze complex networks of molecules, materials, and cells. Analyzing the dynamic structure extracellular matrix can predict cell‐material interactions but not yet demonstrated. In this study, graph theory‐based mathematical modeling RGD ligand inter‐relation is demonstrated by differentially cutting off RGD‐to‐RGD interlinkages with flexibly conjugated magnetic nanobars (MNBs) tunable aspect ratio. The are less effectively cut MNBs a lower ratio, which decreases shortest path while increasing number instances thereof, thereby augmenting nano inter‐relation. This facilitates integrin recruitment macrophages thus actin fiber assembly vinculin expression, mediates pro‐regenerative polarization, involving myosin II, polymerization, rho‐associated protein kinase. Unidirectional pre‐aligning or reversibly lifting highly elongated both increase inter‐relation, promotes host macrophage adhesion switches their polarization from pro‐inflammatory phenotype. latter approach produces nano‐spaces through penetrate establish links thereunder. Using theory, study presents example mathematically functionality extracellular‐matrix‐mimetic help elucidate dynamics occurring between cells materials via versatile geometrical nano‐engineering.
Language: Английский
Citations
0