International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(7), P. 3031 - 3031
Published: March 26, 2025
The
therapeutic
potential
of
extracellular
vesicles
(EVs)
in
reducing
oral
inflammation
is
thoroughly
examined
this
review,
with
an
emphasis
on
gingivitis,
periodontitis,
and
mucositis.
It
explains
the
complex
relationship
between
microbial
dysbiosis
host
immune
responses
aetiology
inflammation.
Pathophysiological
mechanisms
periodontitis
are
examined,
emphasising
roles
played
by
periodontal
pathogens
inflammatory
mediators
disease's
chronic
course
systemic
effects.
Preclinical
research
providing
new
evidence
that
EVs
originating
from
various
cellular
sources
control
cell
dynamics
towards
a
pro-healing
phenotype,
promote
tissue
regeneration,
have
immunomodulatory
qualities.
EV-based
therapies
appear
to
be
promising
technique
benefits
over
traditional
methods
for
treatment
illnesses
specifically
altering
signalling
pathways.
This
review
highlights
improve
patient
outcomes
health
emphasises
need
additional
clinical
clarify
efficacy
underlying
therapy.
Journal of Biomedical Science,
Journal Year:
2025,
Volume and Issue:
32(1)
Published: Jan. 3, 2025
Abstract
The
biomolecular
relevance
of
medium
supplements
is
a
key
challenge
affecting
cell
culture
practice.
composition
commonly
used
differs
from
that
physiological
environment,
the
validity
conclusions
drawn
in
vitro
studies.
This
article
discusses
advantages
and
disadvantages
common
supplements,
including
context-dependent
considerations
for
supplement
selection
to
improve
relevance,
especially
nanomedicine
extracellular
vesicle
research.
Life,
Journal Year:
2025,
Volume and Issue:
15(1), P. 70 - 70
Published: Jan. 9, 2025
Extracellular
vesicles
(EVs)
are
nanosized,
membrane-bound
structures
that
have
emerged
as
promising
tools
for
drug
delivery,
especially
in
the
treatment
of
lysosomal
storage
disorders
(LSDs)
with
central
nervous
system
(CNS)
involvement.
This
review
highlights
unique
properties
EVs,
such
their
biocompatibility,
capacity
to
cross
blood-brain
barrier
(BBB),
and
potential
therapeutic
cargo
loading,
including
enzymes
genetic
material.
Current
therapies
LSDs,
like
enzyme
replacement
therapy
(ERT),
often
fail
address
neurological
symptoms
due
inability
BBB.
EVs
offer
a
viable
alternative,
allowing
targeted
delivery
CNS
improving
outcomes.
We
discuss
recent
advancements
engineering
modification
enhance
targeting,
circulation
time
stability,
provide
detailed
overview
application
Gaucher
Fabry
diseases,
Sanfilippo
syndrome.
Despite
potential,
challenges
remain
scaling
production,
ensuring
isolation
purity,
meeting
regulatory
requirements.
Future
developments
will
focus
on
overcoming
these
barriers,
paving
way
clinical
translation
EV-based
LSDs
other
disorders.
npj Vaccines,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: Jan. 27, 2025
Tumor-derived
exosomes
(TDEs)
mediate
oncogenic
communication,
which
modifies
target
cells
to
reinforce
a
tumor-promoting
microenvironment.
TDEs
support
cancer
progression
by
suppressing
anti-tumor
immune
responses,
promoting
metastasis,
and
conferring
drug
resistance.
Thus,
targeting
could
improve
the
efficacy
of
anti-cancer
treatments
control
metastasis.
Current
strategies
inhibit
TDE-mediated
communication
including
drug-based
genetic
modification-based
inhibition
TDE
release
and/or
uptake,
have
proved
be
inefficient.
In
this
work,
we
propose
surface
engineering
express
foreign
antigens
that
will
trigger
life-long
anti-TDE
responses.
The
possibility
combining
vaccines
with
other
such
as
chemotherapy,
radiotherapy,
targeted
therapy,
surgery
is
also
explored.
Small Methods,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 3, 2025
Abstract
Nanomedicines
have
demonstrated
significant
potential
in
disease
diagnosis
and
therapy,
revolutionizing
traditional
drug
development
patterns.
Recently,
inspired
by
both
natural
engineering
principles,
synthetic
biology
integrates
the
complexity
of
biological
systems
with
precision
to
design
create
novel
components,
devices,
systems.
This
convergence
nanomedicine
has
led
emergence
a
new
concept:
nanomedicine.
Unlike
or
biomimetic
nanomedicines,
nanomedicines
are
designed
using
gene
engineering‐based
strategies.
In
this
Perspective,
foundational
concepts
introduced
its
relationship
to,
differences
from,
explored.
Drawing
from
biology,
also
incorporates
two
main
approaches:
top‐down
bottom‐up
The
latest
advancements
application
reviewed,
these
developments
categorized
according
aforementioned
strategies,
discussion
advantages
challenges
associated
utilizing
is
concluded.
Cancers,
Journal Year:
2025,
Volume and Issue:
17(6), P. 940 - 940
Published: March 10, 2025
Exosomes
have
emerged
as
pivotal
players
in
precision
oncology,
offering
innovative
solutions
to
longstanding
challenges
such
metastasis,
therapeutic
resistance,
and
immune
evasion.
These
nanoscale
extracellular
vesicles
facilitate
intercellular
communication
by
transferring
bioactive
molecules
that
mirror
the
biological
state
of
their
parent
cells,
positioning
them
transformative
tools
for
cancer
diagnostics
therapeutics.
Recent
advancements
exosome
engineering,
artificial
intelligence
(AI)-driven
analytics,
isolation
technologies
are
breaking
barriers
scalability,
reproducibility,
clinical
application.
Bioengineered
exosomes
being
leveraged
CRISPR-Cas9
delivery,
while
AI
models
enhancing
biomarker
discovery
liquid
biopsy
accuracy.
Despite
these
advancements,
key
obstacles
heterogeneity
populations
lack
standardized
protocols
persist.
This
review
synthesizes
pioneering
research
on
biology,
molecular
translation,
emphasizing
dual
roles
both
mediators
tumor
progression
intervention.
It
also
explores
emerging
areas,
including
microbiome–exosome
interactions
integration
machine
learning
exosome-based
medicine.
By
bridging
innovation
with
translational
strategies,
this
work
charts
a
forward-looking
path
integrating
into
next-generation
care,
setting
it
apart
comprehensive
guide
overcoming
technological
hurdles
rapidly
evolving
field.
Cells,
Journal Year:
2025,
Volume and Issue:
14(6), P. 409 - 409
Published: March 11, 2025
Small
extracellular
vesicles
(sEVs),
including
exosomes
as
a
subtype,
with
diameter
typically
less
than
200
nm
and
originating
from
the
endosomal
system,
are
capable
of
transporting
diverse
array
bioactive
molecules,
proteins,
nucleic
acids,
lipids,
thereby
facilitating
intercellular
communication
modulating
cellular
functions.
Vascular
dementia
(VaD)
represents
form
cognitive
impairment
attributed
to
cerebrovascular
disease,
characterized
by
complex
multifaceted
pathophysiological
mechanism.
Currently,
therapeutic
approach
VaD
predominantly
emphasizes
symptom
management,
no
specific
pharmacological
treatment
exists
cure
condition.
Recent
investigations
have
illuminated
significant
role
sEVs
in
pathogenesis
vascular
dementia.
This
review
seeks
provide
comprehensive
analysis
characteristics
functions
sEVs,
particular
focus
on
their
involvement
its
underlying
mechanisms.
The
objective
is
advance
understanding
interplays
between
dementia,
offering
novel
insights
for
future
research
strategies.
