Rapidly Photocurable and Strongly Adhesive Hydrogel‐Based Sealant with Good Procoagulant Activity for Lethal Hemorrhage Control DOI

Yan-Jue Lv,

Yanyan Xu, Shuxiang Zhang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Lethal bleeding from severe trauma or surgical injuries to vital organs threatens the lives of patients. Advanced design efficient hemostatic sealants endowed with both rapid curing and strong tissue adhesion remains a considerable challenge. This study proposes novel strategy that implements covalent linkages biological tissues during sealant curing. A rapidly photocurable strongly adhesive based on diazirine‐conjugated chitosan (DC) is successfully developed, demonstrating gelation time 8 s burst pressure 200 mmHg. The DC accelerates in vitro clotting by facilitating aggregation erythrocytes platelets, as well platelet activation. In liver perforation model, substantially promotes healing hepatic wounds improves survival. not only achieves hemostasis incision, femoral artery perforation, cardiac but also recovery rabbit model. phototriggered opens up new avenue for clinical applications, particularly lethal hemorrhage.

Language: Английский

All-natural biomass-based multifunctional conductive hydrogel for an all-in-one wearable strain sensor DOI Creative Commons
Xugang Dang,

Boyan Guo,

Yuntao Fu

et al.

Published: April 1, 2025

Language: Английский

Citations

0
Rapid hemostatic and bio-adhesive polyphenol powders with physiological extreme condition-tolerance for noncompressible wound healing DOI

Yujia Zheng,

Shengxi Jiang,

Qiaoqiao Zheng

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162231 - 162231

Published: April 1, 2025

Language: Английский

Citations

0
Nanoporous Zeolite Anchored Cellulose Nanofiber Aerogel for Safe and Efficient Hemostasis DOI
Lei Chen,

Zhiping Jin,

Tomoaki Kamiya

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Clay‐based hemostatic materials are commercially available devices designed to control massive bleeding. However, their widespread application is hindered by concerns related material safety and efficacy. In this study, a aerogel composed of cellulose nanofibers (CNFs) Calcium ion‐exchanged nanoporous zeolite developed. CNFs facilitate the in‐situ synthesis zeolites, zeolites firmly embedded within through abundant hydrogen bonds. Notably, loading in only 2.89 wt.%, significantly lower than 18.76 wt.% kaolin content QuikClot combat gauze. Despite low loading, exhibit high efficiency promoting prothrombin‐to‐thrombin conversion accelerating blood clotting. The reduced content, combined with its strong binding matrix, minimizes risks exothermic burns detached particle‐induced distal thrombosis. animal experiments reveal that rapidly controls severe femoral artery bleeding substantially reduces loss. This study presents novel formulation zeolite‐based materials, offering remarkable improvements both

Language: Английский

Citations

0
All-in-one extracellular matrix-based powders with instant self-assembly and multiple bioactivities integrate hemostasis and in-situ tissue functional repair DOI
Chen‐Yu Zou, Han Chen, Ming Xiong

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 50, P. 215 - 231

Published: April 11, 2025

Language: Английский

Citations

0
Rapidly Photocurable and Strongly Adhesive Hydrogel‐Based Sealant with Good Procoagulant Activity for Lethal Hemorrhage Control DOI

Yan-Jue Lv,

Yanyan Xu, Shuxiang Zhang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Lethal bleeding from severe trauma or surgical injuries to vital organs threatens the lives of patients. Advanced design efficient hemostatic sealants endowed with both rapid curing and strong tissue adhesion remains a considerable challenge. This study proposes novel strategy that implements covalent linkages biological tissues during sealant curing. A rapidly photocurable strongly adhesive based on diazirine‐conjugated chitosan (DC) is successfully developed, demonstrating gelation time 8 s burst pressure 200 mmHg. The DC accelerates in vitro clotting by facilitating aggregation erythrocytes platelets, as well platelet activation. In liver perforation model, substantially promotes healing hepatic wounds improves survival. not only achieves hemostasis incision, femoral artery perforation, cardiac but also recovery rabbit model. phototriggered opens up new avenue for clinical applications, particularly lethal hemorrhage.

Language: Английский

Citations

0