Nanobiotechnology Reports, Journal Year: 2024, Volume and Issue: 19(S1), P. S128 - S137
Published: Dec. 1, 2024
Language: Английский
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 30, 2024
Abstract Due to their poor light penetration, photothermal therapy and photodynamic are ineffective in treating deep tissue infections, such as osteomyelitis caused by Staphylococcus aureus ( S. ). Here, a microwave (MW)‐responsive magnetic targeting composite system consisting of ferric oxide (Fe 3 O 4 )/Prussian blue (PB) nanoparticles, gentamicin (Gent), biodegradable poly(lactic‐co‐glycolic acid) (PLGA) is reported. The PLGA/Fe /PB/Gent complex used combination with MW thermal (MTT), dynamic (MDT), chemotherapy (CT) treat acute infected ‐infected. powerful antibacterial effect the determined synergistic effects heat reactive oxygen species (ROS) generation Fe /PB nanoparticles under irradiation effective release Gent at infection site via targeting. mechanism analyzed using bacterial transcriptome RNA sequencing. ROS reduce activity protein transporters on membrane, along transport various ions acceleration phosphate metabolism, which can lead increased permeability damage ribosome DNA, accompany internal efflux bacteria, thus effectively killing bacteria.
Language: Английский
Citations
7
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
Ischemic stroke represents one of the leading cerebrovascular diseases with a high rate mortality and disability globally. To date, there are no effective clinical drugs available to improve long-term outcomes for post-stroke patients. A novel nucleic acid agent circSCMH1 which can promote sensorimotor function recovery in rodent nonhuman primate animal models has been found. However, still delivery challenges overcome its implementation. Besides, effects on cognitive functions remain unexplored. Herein, lipid nanoparticle circSCMH1@LNP1 is established deliver explore therapeutic efficacy comprehensively. Distribution experiments demonstrate that intranasal administration significantly increases distribution peri-infarct region reduces non-specific accumulation other organs compared intravenous injection. Therapeutic results indicate promotes synaptic plasticity, vascular repair, neuroinflammation relief, myelin sheath formation, thereby achieving enhanced mice. In conclusion, this research presents simple LNP system efficient via repair brain injury. It envisioned study may bridge crucial gap between basic translational application, paving way implementation patient management.
Language: Английский
Citations
1
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 30, 2025
Abstract Intracerebral hemorrhage (ICH) causes uncontrolled neuroinflammation/oxidative stress to aggravate secondary brain injury (SBI) for high mortality and disability but lacks effective pharmacotherapy in clinical practices. This represents an imperative need discover potential targets develop advanced therapeutic strategies. Herein, it is discovered that cell‐free DNA (cfDNA, a driving factor of inflammation) level serum positively correlates with SBI severity speculated as targeting molecule. However, traditional cfDNA‐scavenging materials are mainly limited within the polycationic type exist severe side effects. this work designs drug delivery nanosystem, which utilizes pathogenesis‐activated sequential disassembly‐reassembly process situ dual‐scavenge cfDNA ROS regulation stress, thereby reducing preventing further damage experimental mice. The findings not only demonstrate importance also provide enhance toward alleviation on following ICH.
Language: Английский
Citations
1
Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101781 - 101781
Published: April 17, 2025
Depression and cognitive disorders remain major challenges in healthcare, with conventional treatments often facing limitations such as slow onset, side effects, poor drug delivery to the brain. Biomimetic nanodelivery systems, including nanozymes, cell membrane-based exosomes, have emerged promising solutions these issues. These systems leverage natural biological processes enhance targeting, improve bioavailability, regulate complex pathways. Nanoenzymes, their catalytic properties, offer antioxidant anti-inflammatory benefits, while membranes exosomes provide efficient targeting immune evasion. However, remain, immaturity of large-scale production techniques, stability concerns, incomplete understanding mechanisms action. Moreover, long-term safety, pharmacokinetics, toxicity require further investigation. Despite obstacles, potential biomimetic revolutionize depression treatment is significant. Future research should focus on optimizing preparation, improving release, ensuring clinical safety. Multidisciplinary collaboration will be essential for advancing from laboratory practice, offering new therapeutic avenues other neurological disorders.
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: May 30, 2025
Abstract Subarachnoid hemorrhage (SAH), a lethal stroke subtype, involves complex pathological cascades triggered by neuro‐glial units for persistent neuroinflammation, oxidative damage and programmed neuronal cell death. Single‐target traditional multi‐target therapies, derived from individual drugs, show limited efficacy in addressing these interconnected events, due to spatiotemporal heterogeneity of action single‐target components. This highlights the urgent need not only new therapeutic targets, but advanced drugs. Herein, we identify elevated cell‐free DNA (cfDNA), key neuroinflammatory driver, as correlated with SAH severity poor prognosis, suggesting its potential. Furthermore, novel “in situ proliferation” strategy is proposed flexible peptide nanoparticle developed through co‐assembling matrix metalloproteinase‐2 responsive cationic glutathione peroxidase‐mimicking (GPXP). Upon reaching injury lesions, this system splits into two drugs: scavenges cfDNA inhibits microglia‐mediated while GPXP protects neurons against apoptosis/ferroptosis. Consequently, proves superior effects on reducing secondary brain promoting neurofunctional recovery mice. These findings highlight essential role offer resolution advance combinational therapy.
Language: Английский
Citations
0
Theranostics, Journal Year: 2024, Volume and Issue: 14(13), P. 5022 - 5101
Published: Jan. 1, 2024
The potential of intranasal administered imaging agents to altogether bypass the blood-brain barrier offers a promising non-invasive approach for delivery directly brain. This review provides comprehensive analysis advancements and challenges delivering neuroimaging brain by way route, focusing on various modalities their applications in central nervous system diagnostics therapeutics. provide distinct insights into pharmacokinetics, biodistribution, specific interactions within brain, facilitated use tailored tracers contrast agents.
Language: Английский
Citations
2
Nanobiotechnology Reports, Journal Year: 2024, Volume and Issue: 19(S1), P. S128 - S137
Published: Dec. 1, 2024
Language: Английский
Citations
0