Journal of the Taiwan Institute of Chemical Engineers, Journal Year: 2024, Volume and Issue: 167, P. 105823 - 105823
Published: Nov. 28, 2024
Language: Английский
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Abstract Bacterial infections can lead to severe medical complications, including major incidents and even death, posing a significant challenge in clinical trauma repair. Consequently, the development of new, efficient, non‐resistant antimicrobial agents has become priority for practitioners. In this study, stepwise hydrothermal reaction strategy is utilized prepare Fe 3 O 4 @MoS 2 core–shell nanoparticles (NPs) with photosynthesis‐like activity treatment bacterial infections. The NPs continuously catalyze production reactive oxygen species (ROS) from hydrogen peroxide through reactions convert light energy into heat photothermal efficiency 30.30%. addition, photosynthetically generated ROS, combined iron‐induced cell death mechanism NPs, confer them exceptional broad‐spectrum antibacterial properties, achieving activities up 98.62% Staphylococcus aureus , 99.22% Escherichia coli 98.55% methicillin‐resistant . composite exhibits good safety hemocompatibility. Finally, full‐thickness diabetic wound model validates pro‐healing properties chronic wounds. Overall, design photosynthesis‐inspired presents new perspectives developing efficient nano‐enzymatic compounds, offering promising solution challenges drug resistance antibiotic misuse.
Language: Английский
Citations
1
ACS Nano, Journal Year: 2025, Volume and Issue: 19(2), P. 1861 - 1864
Published: Jan. 21, 2025
InfoMetricsFiguresRef. ACS NanoVol 19/Issue 2Article This publication is free to access through this site. Learn More CiteCitationCitation and abstractCitation referencesMore citation options ShareShare onFacebookX (Twitter)WeChatLinkedInRedditEmailJump toExpandCollapse Letter the EditorJanuary 21, 2025Comment on "Pathogenesis-Guided Rational Engineering of Nanotherapies for Targeted Treatment Abdominal Aortic Aneurysm by Inhibiting Neutrophilic Inflammation"Click copy article linkArticle link copied!Heng WangHeng WangCentre Transplant Renal Research, Westmead Institute Medical The University Sydney, New South Wales 2145, AustraliaMore Heng Wanghttps://orcid.org/0000-0001-7408-0398Keyi FanKeyi FanDepartment Vascular Surgery, Second Hospital Shanxi University, Taiyuan, 030001, ChinaMore Keyi FanXiaohua JiaXiaohua JiaKey Laboratory Molecular Imaging Chinese Academy Sciences, Automation, Beijing 100190, Xiaohua JiaRuijing Zhang*Ruijing ZhangDepartment Nephrology, China*Email: [email protected]More Ruijing ZhangHonglin Dong*Honglin DongDepartment Honglin DongGuoping Zheng*Guoping ZhengCentre Australia*Email: Guoping ZhengOpen PDFACS NanoCite this: Nano 2025, 19, 2, 1861–1864Click citationCitation copied!https://pubs.acs.org/doi/10.1021/acsnano.4c12263https://doi.org/10.1021/acsnano.4c12263Published January 2025 Publication History Received 2 September 2024Accepted 2025Revised 22 November 2024Published online 21 2025Published in issue 2025letterCopyright © Published American Chemical Society. available under these Terms Use. Request reuse permissionsThis licensed personal use PublicationsCopyright SocietySubjectswhat are subjectsArticle subjects automatically applied from Subject Taxonomy describe scientific concepts themes article.CellsImmunologyInflammationNanoparticlesRodent modelsRecently, Hu et al. (1) designed a nanotherapy targeting aortic abdominal aneurysm (AAA) inhibiting neutrophil inflammation. approach based lumino-conjugated α-cyclodextrin materials (LaCD), which anti-inflammatory nanoparticles (LaCD NPs) were synthesized. capability nanoprobe neutrophils was also demonstrated their previous study. (2) Additionally, modifying LaCD NPs with alendronate sodium, (AlaCD obtained, significantly enhanced ability target calcification within aneurysm. modification thereby inhibits neutrophil-mediated inflammatory responses aneurysm, particularly proinflammatory effects extracellular traps (NETs), matrix degradation, promotion vascular smooth muscle cell apoptosis.A Brief Overview Nanotherapeutics AAAClick section linkSection copied!Nanotherapeutics AAA represent an emerging trend treatment human disease. Nanomaterials possess unique properties such as high surface area, small size effects, potential, making them suitable drug delivery, (3) imaging guidance, (4) tissue repair. These help achieve therapeutic concentrations at lesion sites, that difficult conventional methods. Various nanomedicines have shown potential animal models (Table 1).Table 1. Examples Nanomedicine Delivery AAADiseaseNanoparticlesTargetsEffectsAAA, Rats (5)Rapamycin-loaded PEG-b-PBLGBeing endocytosed macrophagesThe level inhibitedAAA, (6)Cation functionalized PLGA-PANPFibrin clot intraluminal thrombusThe intracavitary thrombus dissolvedAAA, Mice (3)EVMS@RGD-HBc NCMacrophages cells expression αvβ3Inhibition macrophage polarization phenotypic switchingAAA, (7)EL-BSA-NP-PGGDamaged elastinInhibition recruitmentAAA, (8)Nanoparticles vesicles (EVs) derived mesenchymal stem (MSC)Immune cellsReduced inflammation activationAAA, (20)Supramolecular nanofibers using peptide amphiphile moleculesFragmented elastin, metalloproteinase (MMP-2), membrane type 1 metalloproteinaseOnly targeted localizationAAA, (21)TPN-siRNA, formed oxidative polymerization self-assembly epigallocatechin gallateMacrophages cellsA siRNA released silence MMP-2 MMP-9, promote M1 M2 repolarization macrophages, inhibit apoptosisAAA, (22)A rapamycin-loaded oxidation-responsive β-cyclodextrin materialIntegrins membranesIt attenuated infiltration CD68 macrophages outer rupture media rat AAA, reduced calcification, inhibited elastin degradationNanomedicine can be passively lesions or taken up specific cells, leveraging structure injured artery. For example, PEG-b-PBLG loaded rapamycin accumulate microdefects reducing being macrophages. (5) Another example PLGA-PANP, targets fibrin clots, helping reduce arterial injury. (6)Active involves conjugating ligands attaching drug-loaded cells. Fandi Mo developed EVMS@RGD-HBc NC viral actively αvβ3 coordinating microenvironment. Nasim Nosoudi constructed EL-BSA-NP-PGG nanoframe carriers damaged elastin-targeting particles recruitment tissues calcium chloride rats. (7)Nanoparticles internalized hitchhiking effect, responding signals sites delivery. Michael Spinosa discovered (MSC) -derived could modulate response progression via miR-147. (8)Several studies highlight advantages nanoparticles, sustained release lower concentrations. demonstrate efficacy protecting elastic fibers, though further research needed clarify immunogenicity, stability, bioavailability clinical translation. while nanomaterial-based photothermal therapy used cancer treatment, it remains unexplored AAA.Limitations StudyClick copied!To our knowledge, first study address therapy, paving way precision other diseases. has following limitations require clarification.1.Myeloperoxidase (MPO) not sufficiently precise marker neutrophils. MPO protein believed secreted both diseases, atherosclerosis, positively correlated plaque vulnerability. (9,10) To certain extent, reasonable choose state reflect activity However, legend Figure S1B accurate, would more rigorously represented markers Ly6G.2.Improving probe's vivo imaging. noted "due deep location aorta abdomen low accumulation Cy5/LaCD aortas relative major organs.″ Consequently, subsequent studies, they abandoned favor ex fluorescence (see original S5, 2F). Observation only visualize distribution characteristics nanomaterials but reveal changes metabolism. Using different strategies improve physical chemical fluorescent probes understand physiological processes diagnosis, prognosis We suggest near-infrared dyes Cy7 IRDye 800CW enhance penetration. (11,12) coupling Fe3O4 magnetic resonance nanoparticle overcome depth (13) may worthwhile explore mice, dorsal imaging, fasting dehydration protocols. (14) Developing integrated diagnostic platform significant implications.3.The fate monocytes peripheral blood. proposed "LaCD bloodstream, followed hitchhiking-effect-mediated translocation aneurysmal due cells." Figures 5F-J S18 indicate exhibit decreased migratory capacity, factor release, diminished recruit treatment. Therefore, after intravenous injection, immune metabolized degraded, resulting limited quantity reaching In future authors attempt elucidate interaction between carrier On one hand, cultured vitro viability migration engulfing examined relation dose time administration. then infused back into mice vivo, real-time elucidation quantification vector-cell viability. isolated animals, aggregation residual should detected times expect confirm will critical translation.4.Hu conducted RNA sequencing suggested close relationship activation. technique cannot ascertain cellular origin MPO. Performing single-cell purified yield results.5.Utilize common models. Among existing models, widely used. (15) Methods adventitial application porcine pancreatic elastase, CaCl2 solution infusion, angiotensin II slow-release pump implantation commonly (16−18) agree choosing experimental model; larger essential transition humans, especially context applications new technologies, including nanoparticles. no single modeling method fully true complexity AAA. Employing multiple acute chronic aneurysms provide accurate representation various scenarios pathogenesis. It closer pathological crucial mechanism pathophysiology identification targets. look forward validation excellent performance studies.6.Additionally, there some minor errors 3F 3G, intimal integrity content stained EVG 50 mg/kg group do appear show improvement. S9, dye Cy5 rather than Cy3. S11, appears deposition indicated alizarin red staining shows insufficient structural integrity. Quantitative analysis objectively clearly support results. addition, we replace representative images, readers effect intuitively.The purpose letter offer relevant knowledge suggestions improvement, affect results conclusions al.'s hope researchers additional approaches disease mortality rupture. Currently, preoperative detection practice primarily relies morphological techniques computed tomography angiography (CTA) ultrasound (19) presented precision-targeted strategy diseases immunological perspective, offering translational potential.Finally, like acknowledge extensive work thank designing delivery system aimed improving therapy.Author InformationClick copied!Corresponding AuthorsRuijing Zhang - Department China; Email: protected]Honglin Dong protected]Guoping Zheng Centre Australia; protected]AuthorsHeng Wang https://orcid.org/0000-0001-7408-0398Keyi Fan ChinaXiaohua Jia Key ChinaAuthor ContributionsThe manuscript written contributions all authors. All given approval final version manuscript.FundingThis supported NHMRC Ideas grant 2027965 Translational Medicine Research Center Diseases Province, China (Grant No. 2022017).AbbreviationsClick copied!AAAaortic aneurysmLaCD NPslumino-conjugated nanoparticlesNETsneutrophil trapsMSCmesenchymal cellEVsextracellular vesiclesMPOmyeloperoxidaseCTAcomputed angiographyReferencesClick copied! references publications. 1Hu, K.; Zhong, L.; Lin, W.; Zhao, G.; Pu, Feng, Z.; Zhou, M.; Ding, J.; Zhang, J. Pathogenesis-Guided Inflammation. 2024, 18 (8), 6650– 6672, DOI: 10.1021/acsnano.4c00120 Google ScholarThere corresponding record reference.2Tao, H.; Guo, Ma, Y.; Jin, T.; Gu, Dou, Liu, Hu, Xiong, X.; Luminescence Acute Liver Injury Biodegradable Biocompatible Nanoprobes. 2020, 14 (9), 11083– 11099, 10.1021/acsnano.0c00539 Scholar2Luminescence NanoprobesTao, Hui; Jiawei; Yongchang; Yang; Taotao; Lijuan; Yin; Jinyi; Houyuan; Xiaoxing; JianxiangACS (2020), 11083-11099CODEN: ANCAC3; ISSN:1936-0851. (American Society) injury result hepatic fatty liver, liver fibrosis, hepatitis, failure, mainly responsible global morbidity. Early diagnosis crit. Herein report luminescence injury, alc. (ALI) failure (ALF). purpose, biodegradable luminescent material chem. functionalization cyclic oligosaccharide, produced nanoprobes (defined NPs). dependent reactive oxygen species myeloperoxidase (MPO). Correspondingly, activated specifically imaged NPs, signal pos. assocd. count. mouse ALI ALF, enabled tracking livers. cases, intensity consistent time-dependent profiles neutrophils, MPO, parameters pathogenesis Moreover, capacity addnl. improved neutrophil-targeting peptide. addn., preliminary good safety NPs. effective biocompatible dynamic development promising neutrophil-assocd. >> SciFinder ®https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADC%252BB3cXhsFOisb%252FN&md5=46acf3fc91a4bf907428cfae74a9f1fa3Mo, F.; Wang, C.; Li, S.; Xiao, E.; P.; Yuan, Zuo, Fu, Chen, Ren, L. A Dual-Targeting, Multi-Faceted Nanodrug Optimizes Microenvironment Ameliorate Aneurysm. Advanced (Deerfield Beach, Fla.) 36 (33), e2405761 10.1002/adma.202405761 reference.4Wang, R.; Jia, Gao, Fan, Qiao, Yan, Hui, Dong, H. Highly sensitive particle NETosis anti-Ly6G iron oxide Cell death discovery 10 (1), 395, 10.1038/s41420-024-02156-3 reference.5Shirasu, Koyama, Miura, Hoshina, Kataoka, Watanabe, T. Nanoparticles Effectively Target Rapamycin Sites Experimental Rats. PloS 2016, 11 (6), e0157813 10.1371/journal.pone.0157813 reference.6Sivaraman, B.; Sylvester, A.; Ramamurthi, A. Fibrinolytic PLGA slow lysis attenuate proteolytic loss matrix. Materials science & engineering. C, biological 59, 145– 156, 10.1016/j.msec.2015.09.056 reference.7Nosoudi, N.; Chowdhury, Siclari, Parasaram, V.; Karamched, Vyavahare, N. Systemic Loaded Pentagalloyl Glucose Protects Elastic Lamina Prevents Journal cardiovascular 9 (5–6), 445– 455, 10.1007/s12265-016-9709-x reference.8Spinosa, Lu, Su, Bontha, S. Gehrau, Salmon, M. D.; Smith, Weiss, Mas, V. Upchurch, G. R., Jr.; Sharma, K. Human stromal cell-derived formation activation microRNA-147. FASEB journal: official Federation Societies Biology 2018, 32 (11), 6038 10.1096/fj.201701138RR reference.9Rashid, I.; Maghzal, Y. Cheng, Talib, Newington, Vajandar, Searle, Maluenda, Lindstedt, E. Jabbour, Kettle, Bongers, Power, Michaelsson, Peter, Stocker, R. Myeloperoxidase molecular stabilization high-risk atherosclerotic plaque. Eur. Heart 39 (35), 3301– 3310, 10.1093/eurheartj/ehy419 Scholar9Myeloperoxidase plaqueRashid, Imran; Ghassan Yung-Chih; David; Jihan; Darren; Minqin; Saumitra Amy; Ana; Eva-Lotte; Andrew; Antony Andre; Carl; Erik; Karlheinz; RolandEuropean (2018), 3301-3310CODEN: EHJODF; ISSN:1522-9645. (Oxford Press) As enzyme abundant ruptured plaques, investigate role employed tandem stenosis model instability apolipoprotein E gene knockout (Apoe-/-) mice. test Mpo-/-Apoe-/- 2-thioxanthine inhibitor AZM198. assessed liq. chromatog.-tandem mass spectrometry 2-chloroethidium generation hydroethidine bis-5HT-DTPA-Gd (MPO-Gd) mol. (MRI), phenotype verified histol. two-fold greater unstable compared stable phenotype. Genetic deletion increased fibrous cap thickness, haemosiderin AZM198 thickness phenotype, without affecting blood circulating leukocytes lipids. MPO-Gd MRI enhancement T1-weighted Mpo gene. Our data implicate non-invasive pharmacol. inhibition hold promise clin. translation management coronary artery ®https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADC%252BC1MXhtlKju7bK&md5=287250d7c0704abde344944ca95d2ac110Sugiyama, Okada, Sukhova, Virmani, Heinecke, Libby, P. Macrophage regulation granulocyte colony-stimulating atherosclerosis implications syndromes. Am. Pathol. 2001, 158 (3), 879– 91, 10.1016/S0002-9440(10)64036-9 Scholar10Macrophage syndromesSugiyama, Seigo; Yoshikatsu; Galina Renu; Jay PeterAmerican Pathology (2001), 879-891CODEN: AJPAA4; ISSN:0002-9440. Society Investigative Pathology) Inflammation stress contribute many atherosclerosis. atheroma contains levels produces pro-oxidant species, hypochlorous acid (HOCl). documents nos. myeloperoxidase-expressing eroded plaques causing contrast, streaks contain little myeloperoxidase. Granulocyte factor, selectively regulates express produce HOCl vitro. myeloperoxidase-pos. co-localized factor. Pro-inflammatory stimuli known present plaque, CD40 ligand, lysophosphatidylcholine, cholesterol crystals, induce prodn. HOCl-modified proteins accumulated atheroma. identify endogenous regulator particular complication ®https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADC%252BD3MXitlOnurY%253D&md5=ef265d90189152083a67c4a96cb6be9f11Tong, Shang, Tian, Q.; Yang, vulnerable active myeloperoxidase-targeted Theranostics 2021, (2), 506– 521, 10.7150/thno.49812 reference.12Zhang, Liang, Zhu, Du, Xue, Optical multimodality plectin-1-targeted agent orthotopic ductal adenocarcinoma EBioMedicine 2022, 80, 104040 10.1016/j.ebiom.2022.104040 Scholar12Optical miceZhang, Wenjia; Xiaolong; Liang; Xinyu; Zhengyu; Jie; HuadanEBioMedicine (2022), 80 (), 104040CODEN: EBIOAX; ISSN:2352-3964. (Elsevier B.V.) Pancreatic (PDAC) lethal malignancy worldwide, challenging currently. Magnetic (MPI) internal PDAC tumors because its sensitivity unlimited depth. utilize MPI, combination (FMI) advance xenografts. plectin-1 IRDye800CW conjugated superparamagnetic (PTP-Fe3O4-IRDye800CW) PDAC-targeting triple-modality S.c. established. FMI, performed quant. observation tumors. Histol. analyses validation. PTP-Fe3O4-IRDye800CW possessed great expressed multi-modality higher specificity, even distribution, longer retention over 7 d Con-Fe3O4-IRDye800CW (MPI, 2d post-injection: PTP-Fe3O4-IRDye800CW: 85.72% ± 1.53% vs. Con-Fe3O4-IRDye800CW: 74.41% 1.91%, **P < 0.01 (Student's t test)). Ex Prussian blue stainings validate probes. demonst
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 800 - 817
Published: Feb. 18, 2025
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: April 4, 2025
Abstract Abdominal aortic aneurysm (AAA) is the most common true worldwide, and recent studies suggest that dendritic cells (DCs) play a key role in its development, though specific subtypes underlying mechanisms remain unclear. In this study, of interferon regulatory factor 8 (IRF8) AAA investigated by focusing on effect differentiation DC precursors into conventional type 1 (cDC1s). It found significant infiltration HLA‐DR + IRF8 human tissue samples. mice, DC‐specific overexpression Irf8 exacerbates expansion following periadventitial elastase application, while deletion attenuates development. Batf3 −/− which lack cDC1s, exhibit characteristics similar to ‐deleted mice. Additionally, an increased population activated CD8 T observed DC‐ overexpressed mice show decrease these cells. Blocking antigen cross‐presentation also reduces progression. Tissue microarray analysis samples further confirms correlation between expression These findings activation promotes cDC1 differentiation, leading recruitment cells, contribute wall destruction formation.
Language: Английский
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Current Atherosclerosis Reports, Journal Year: 2025, Volume and Issue: 27(1)
Published: May 22, 2025
Language: Английский
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0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 16, 2025
Abstract Xenogeneic decellularized adipose matrix(DAM) scaffolds are significant in soft tissue regeneration by addressing donor site morbidity and limited availability. However, natural DAM xenotransplantation remains unachieved. Previous efforts have relied on chemical modifications to reduce foreign body reactions, with inherent drawbacks outcomes. This study proposes a hydrogel scaffold that achieves efficient functional xenotransplant fat regeneration. Primarily, hydrophilic DAM(H‐DAM) is confirmed lower antigen content, but its regenerative potential constrained encapsulation impedes seed cell infiltration. Thus, H‐DAM prepared enhance the speed extent of It observed topological structure impacts infiltration, immune inflammatory response, Low‐crosslinked hydrogels emerged as optimal for adipogenic differentiation due loose networks degradation rates synchronizing Furthermore, wall‐like rather than filamentous provides superior niche stem engraftment activity. Finally, integrated multi‐omics data analysis demonstrated regenerated functionally mimics native tissue. These findings indicate xenogeneic gel support both structural reconstruction tissue, offering novel insights promising approach clinical translation DAM‐based therapies.
Language: Английский
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0
Journal of the Taiwan Institute of Chemical Engineers, Journal Year: 2024, Volume and Issue: 167, P. 105823 - 105823
Published: Nov. 28, 2024
Language: Английский
Citations
2