Gram‐Negative Bacteria Targeting AIE Photosensitizer for Selective Photodynamic Killing of Vibrio vulnificus DOI Creative Commons
Hangshu Xin,

Qiang Lin,

Simin Sun

et al.

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

ABSTRACT Vibrio vulnificus is a highly virulent Gram‐negative bacterium exhibiting extensive resistance to various antibiotics, presenting significant challenges for efficient and selective eradication. Recently, photosensitizer (PS)‐based photodynamic therapy has emerged as an effective strategy against bacteria biofilms. However, traditional PS struggles penetrate the unique membrane structure of such V. , while avoiding traversal barrier eukaryotic cells. To address this issue, herein, named BDTP with aggregation‐induced emission properties was developed. can specifically target DNA but integrate into cell membrane, preventing damage contents in cells due its hydrophilic/lipophilic “Y‐shaped” structural characteristics. In dark conditions, functions antibiotic, inhibiting bacterial proliferation. Upon white light stimulation, induce phototoxic effectively inhibit/clear Additionally, significantly reduces PS‐induced nucleic acids. This promotes healing infected wounds ‐infected mice. Our work introduces first targeting ‐associated infections, demonstrating efficacy both vitro vivo.

Language: Английский

Engineered Silicon-Titania heterojunction elicits catalytic cancer cell death DOI

Deliang Xu,

Tingting Xu, Min Ge

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159226 - 159226

Published: Jan. 1, 2025

Language: Английский

Citations

1
Hydrogen‐Bonded Organic Framework Nanoscintillators for X‐Ray‐Induced Photodynamic Therapy in Hepatocellular Carcinoma DOI Open Access

Lihui Gu,

Han Wu, Xu Li

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract X‐ray induced photodynamic therapy (X‐PDT) leverages penetrating to generate singlet oxygen ( 1 O 2 ) for treating deep‐seated tumors. However, conventional X‐PDT typically relies on heavy metal inorganic scintillators and organic photosensitizers produce , which presents challenges related toxicity energy conversion efficiency. In this study, highly biocompatible phosphorescent nanoscintillators based hydrogen‐bonded frameworks (HOF) are designed engineered, termed BPT‐HOF@PEG, enhance in hepatocellular carcinoma (HCC) treatment. BPT‐HOF@PEG functions simultaneously as both scintillator photosensitizer, effectively absorbing transferring abundant . Both vitro vivo investigations demonstrate that internalized efficiently produces significant quantities of upon irradiation. Additionally, exposure directly inflicts DNA damage, the synergistic effects these mechanisms result pronounced cell death substantial tumor growth inhibition, with a inhibition rate up 90.4% assessments. RNA sequencing analyses reveal induces apoptosis Hepa1‐6 cells while inhibiting proliferation, culminating death. Therefore, work highlights considerable potential efficient HOF nanoscintillators‐based promising therapeutic approach HCC, providing effective alternative negligible patients unresectable

Language: Английский

Citations

1
Thiophene engineering of near-infrared D-π-A nano-photosensitizers for enhanced multiple phototheranostics and inhibition of tumor metastasis DOI
Xingyu Zhao,

Jiaping Shen,

Huixuan Qi

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 685, P. 291 - 303

Published: Jan. 17, 2025

Language: Английский

Citations

1
Triphenylamine‐Substituted Nile Red Derivatives with Efficient Reactive Oxygen Species Generation for Robust and Broad‐Spectrum Antimicrobial Photodynamic Therapy and Abscess Wound Healing DOI Open Access
Jianan Dai, Laiping Fang,

Zhijin Fan

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Abstract Infections caused by drug‐resistant bacteria represent a major contributor to high mortality rates, underscoring the urgent need for effective non‐antibiotic drugs and alternative therapies. Antimicrobial photodynamic therapy (aPDT) emerges as an innovative treatment due its minimal drug resistance. Herein, series of Nile Red derivatives is synthesized donor engineering strategy. Notably, NTPA featuring triphenylamine (TPA) electron‐donating group, exhibited highest production reactive oxygen species (ROS). The enhanced electron donating‐accepting (D‐A) property effectively reduced energy gap between S 1 T (ΔE S‐T ), facilitating intersystem crossing (ISC) with larger spin‐orbit coupling (SOC) constant. Furthermore, twisted conformation profoundly suppressed quenching ROS. As expected, over 470‐fold increase in ROS observed, predominantly comprising type‐I nanoparticles (NPs) exceptional vitro killing ability against various bacteria, inhibition efficiency even reaching 99.9%. In methicillin‐resistant staphylococcus aureus (MRSA)‐induced abscess model, NPs facilitated complete wound healing within just 8 days following single administration irradiation, highlighting their bactericidal wound‐healing promotion capabilities. Overall, this work inspired construction efficient Red‐based photosensitizers (PSs) development new broad‐spectrum aPDT method treatment.

Language: Английский

Citations

1
Long‐Range π‐π Stacking Brings High Electron Delocalization for Enhanced Photocatalytic Activity in Hydrogen‐Bonded Organic Framework DOI Open Access
An‐An Zhang,

Z.G Wang,

Zhi‐Bin Fang

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(46)

Published: Aug. 8, 2024

Abstract Unlike many studies that regulate transport and separation behaviour of photogenerated charge carriers through controlling the chemical composite, our work demonstrates this goal can be achieved simply tuning molecular π–π packing from short‐range to long‐range within hydrogen‐bonded organic frameworks (HOFs) without altering building blocks or network topology. Further investigations reveal stacking significantly promotes electron delocalization enhances density, thereby effectively suppressing electron‐hole recombination augmenting transfer rate. Simultaneously, acting as a porous substrate, it boosts density Pd nanoparticle loaded on its surfaces, resulting in remarkable CO 2 photoreduction catalytic activity (CO generation rate: 48.1 μmol/g/h) need for hole scavengers. Our study provide insight into regulating carrier behaviours assemblies based hydrogen bonds, offering new clue efficient photocatalyst design.

Language: Английский

Citations

4
Freestanding Hydrogen‐Bonded Organic Framework Membrane for Efficient Wound Healing DOI
Lingling Wu, Xue Yang,

Haonan Jia

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

Abstract Hydrogen‐bonded organic frameworks (HOFs) are emerging as multifunctional materials with exceptional biocompatibility, abundant active sites, and tunable porosity, which highly beneficial for advanced wound care. However, a significant challenge involves transforming pristine HOFs powders into lightweight, ultrathin, freestanding membranes compatible soft biological systems. Herein, the study successfully develops shape‐adaptive HOF‐based matrix (HMMs) using polymer‐assisted liquid‐air interface technique. The HMMs conform seamlessly to tissues of different sizes shapes, effectively stopping bleeding, provide high water‐vapor permeability. Notably, both in vitro vivo studies mice models demonstrated that these tissue‐conformable significantly accelerate healing by modulating inflammatory environment injured tissue promoting rapid re‐epithelialization. Furthermore, RNA‐seq analysis mechanistic revealed reduce inflammation facilitate transition from proliferative stage remodeling skin development. This work not only opens up new avenues care but also establishes foundation hybridizing polymers wide range potential applications.

Language: Английский

Citations

4
Multivariate synergy for heightening ionic HOF robustness and proton conductivity DOI

Xiang‐Tian Bai,

Li‐Hui Cao,

Xu‐Yong Chen

et al.

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

Citations

0
Polyoxalate with aggregation-induced emission feature as a self-immolative polymeric photosensitizer for efficient photodynamic therapy DOI
Yu Hou Wu, Yiping Liu, Tongsheng Huang

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 136477 - 136477

Published: Feb. 1, 2025

Language: Английский

Citations

0
2D Undulated Metal Hydrogen-Bonded Organic Frameworks with Self-Adaption Interlayered Sites for Highly Efficient C–C Coupling in the Electrocatalytic CO2 Reduction DOI Creative Commons

Jianning Lv,

Wenrui Li, Shuai Li

et al.

Nano-Micro Letters, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 24, 2025

Abstract The hydrogen-bonded organic frameworks (HOFs) as a new type of porous framework materials have been widely studied in various areas. However, the lack appropriate active sites, low intrinsic conductivity, and poor stability limited their performance field electrocatalysis. Herein, we designed two 2D metal (2D–M–HOF, M = Cu 2+ or Ni ) with coordination compounds based on 2,3,6,7,14,15-hexahydroxyl cyclotricatechylene transition ions (Cu ), respectively. crystal structure 2D–Cu–HOF is determined by continuous rotation electron diffraction, indicating an undulated hydrogen-bond network interlayered π-π stacking. flexible 2D–M–HOF leads to formation self-adaption resulting superior activity selectivity electrocatalytic conversion CO 2 C products, achieving total Faradaic efficiency exceeding 80% due high-efficiency C–C coupling. experimental results density functional calculations verify that enables energetically favorable *OCCHO intermediate. This work provides promising strategy for designing HOF catalysts electrocatalysis related processes.

Language: Английский

Citations

0
Synthesis of Ceo2@Cao Composite Antibacterial Materials and Their Use for Water Treatment and Mb Dye Degradation DOI

Qianqian Guo,

Xianggeng Wei, Donghui Yang

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0