Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 26, 2024
ABSTRACT
Vibrio
vulnificus
is
a
highly
virulent
Gram‐negative
bacterium
exhibiting
extensive
resistance
to
various
antibiotics,
presenting
significant
challenges
for
efficient
and
selective
eradication.
Recently,
photosensitizer
(PS)‐based
photodynamic
therapy
has
emerged
as
an
effective
strategy
against
bacteria
biofilms.
However,
traditional
PS
struggles
penetrate
the
unique
membrane
structure
of
such
V.
,
while
avoiding
traversal
barrier
eukaryotic
cells.
To
address
this
issue,
herein,
named
BDTP
with
aggregation‐induced
emission
properties
was
developed.
can
specifically
target
DNA
but
integrate
into
cell
membrane,
preventing
damage
contents
in
cells
due
its
hydrophilic/lipophilic
“Y‐shaped”
structural
characteristics.
In
dark
conditions,
functions
antibiotic,
inhibiting
bacterial
proliferation.
Upon
white
light
stimulation,
induce
phototoxic
effectively
inhibit/clear
Additionally,
significantly
reduces
PS‐induced
nucleic
acids.
This
promotes
healing
infected
wounds
‐infected
mice.
Our
work
introduces
first
targeting
‐associated
infections,
demonstrating
efficacy
both
vitro
vivo.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 19, 2025
Magnetic
resonance
imaging
(MRI)
often
employs
contrast
agents
(CAs)
to
improve
the
visualization
of
lesions.
Although
iron-based
oxides
have
been
clinically
approved
as
T2
CAs,
various
obstacles
hindered
their
widespread
commercial
use.
Consequently,
there
is
a
pressing
demand
for
innovative
T2-type
CAs.
Herein,
we
synthesized
an
hydrogen-bonded
organic
framework
(Fe-HOF)
from
Fe-TCPP
and
explored
its
potential
T2-weighted
MRI
CA.
The
Fe-HOF
demonstrated
superior
relaxivity
(r2)
32.067
mM–1
s–1
higher
r2/r1
ratio
45.25
compared
Fe-TCPP.
This
enhancement
may
be
attributed
combination
single-atom
form
Fe3+
with
increased
radius.
Our
findings
indicate
that
6
μmol
[Fe]/kg
dose
significantly
improves
lesion
in
scans
subcutaneous
tumor
model
mice
liver
metastasis
breast
tumor.
simplicity
Fe-HOF'
s
structure
ensures
absence
complex
metal
ions
or
ligands
during
synthesis,
iron
component
can
metabolized
into
endogenous
pool,
resulting
remarkable
biocompatibility
biosafety.
These
pave
way
design
novel
probes
tailored
cancer
characterization
at
stages.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 3, 2025
Abstract
Organic
room‐temperature
phosphorescence
(RTP)
materials
with
tunable
emission
colors,
lifetime,
and
quantum
yield
have
important
implications
for
applications
in
optoelectronics,
bioimaging,
anti‐counterfeiting.
Herein,
a
facile
strategy
is
presented
multi‐parameters
switchable
RTP
by
introducing
second
H‐bonding
units
(SHUs)
capable
of
adsorption
desorption,
such
as
H
2
O
DMSO,
into
hydrogen‐bonded
organic
crystals.
It
found
that
the
incorporation
molecules
HOC‐PM‐H
structure
establishes
robust
hydrogen
bonding
network
stabilizes
triplet
excited
states,
thereby
suppressing
non‐radiative
transitions
extending
lifetime
to
904
±
45
ms.
In
contrast,
DMSO
HOC‐PM‐DMSO
promote
separation
aggregate
leading
transition
from
yellow‐green
blue
up
63%.
The
performance
can
be
reversibly
switched
SHUs.
By
leveraging
temporal
spatial
changes
color,
an
information
security
system
afterglow
displays
activated
SHUs
are
developed.
SHUs‐activated
not
only
provides
platform
revealing
structure‐property
relationships
but
also
offers
novel
approach
designing
advanced
functional
specific
luminescent
properties.
Chemistry - An Asian Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 8, 2025
Abstract
Bacterial
infections
remain
a
significant
and
escalating
threat
to
global
health,
exacerbated
by
multidrug‐resistant
strains
that
undermine
the
efficacy
of
conventional
antibiotics.
This
pressing
issue
underscores
urgent
need
for
development
new
antimicrobial
materials.
Among
these,
molecular‐based
crystalline
porous
materials,
such
as
metal–organic
frameworks
(MOFs),
covalent
organic
(COFs),
hydrogen‐bonded
(HOFs),
supramolecular
assembly
(SAFs),
have
emerged
promising
class
antibacterial
agents.
These
materials
exhibit
well‐defined
crystallinity
tunable
structures,
offering
exceptional
versatility
applications.
Notably,
their
high
surface
area,
adjustable
pore
size,
potential
functionalization
enable
efficient
loading
controlled
release
agents,
including
metal
ions
molecules.
review
provides
comprehensive
analysis
recent
advancements
in
this
field,
highlighting
design
strategies,
structural
diversity,
mechanisms,
Finally,
we
discuss
current
challenges
outline
future
opportunities
practical
deployment
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(46)
Published: Aug. 8, 2024
Abstract
Unlike
many
studies
that
regulate
transport
and
separation
behaviour
of
photogenerated
charge
carriers
through
controlling
the
chemical
composite,
our
work
demonstrates
this
goal
can
be
achieved
simply
tuning
molecular
π–π
packing
from
short‐range
to
long‐range
within
hydrogen‐bonded
organic
frameworks
(HOFs)
without
altering
building
blocks
or
network
topology.
Further
investigations
reveal
stacking
significantly
promotes
electron
delocalization
enhances
density,
thereby
effectively
suppressing
electron‐hole
recombination
augmenting
transfer
rate.
Simultaneously,
acting
as
a
porous
substrate,
it
boosts
density
Pd
nanoparticle
loaded
on
its
surfaces,
resulting
in
remarkable
CO
2
photoreduction
catalytic
activity
(CO
generation
rate:
48.1
μmol/g/h)
need
for
hole
scavengers.
Our
study
provide
insight
into
regulating
carrier
behaviours
assemblies
based
hydrogen
bonds,
offering
new
clue
efficient
photocatalyst
design.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 8, 2024
Abstract
Hydrogen-bonded
organic
frameworks
(HOFs),
with
their
excellent
biocompatibility,
diverse
chemical
functionalities,
and
well-organized
porous
structures,
represent
a
versatile
promising
platform
for
biomedical
applications.
However,
manufacturing
pristine
HOFs
powders
into
lightweight,
ultrathin,
freestanding
membranes
compatible
soft
tissues
of
arbitrary
shape
size
has
been
significant
challenge.
Herein,
we
successfully
prepared
shape-adaptive
HOFs-based
matrix
(HMMs)
using
polymer-assisted
liquid-air
interface
technique.
These
are
capable
conforming
to
different
sizes
shapes,
effectively
stopping
bleeding
exhibiting
high
water-vapor
permeability.
Remarkably,
in
vitro
vivo
studies
mice
demonstrated
that
the
tissue-conformable
accelerate
wound
healing
by
regulating
inflammatory
environment
damaged
tissue
promoting
faster
re-epithelialization.
Furthermore,
RNA-seq
analysis
mechanistic
revealed
HMMs
reduce
inflammation
facilitate
transition
from
proliferative
stage
remodeling
skin
development.
This
work
provides
new
insights
use
multifunctional
healthcare
management
paves
way
hybridizing
polymers
Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 26, 2024
ABSTRACT
Vibrio
vulnificus
is
a
highly
virulent
Gram‐negative
bacterium
exhibiting
extensive
resistance
to
various
antibiotics,
presenting
significant
challenges
for
efficient
and
selective
eradication.
Recently,
photosensitizer
(PS)‐based
photodynamic
therapy
has
emerged
as
an
effective
strategy
against
bacteria
biofilms.
However,
traditional
PS
struggles
penetrate
the
unique
membrane
structure
of
such
V.
,
while
avoiding
traversal
barrier
eukaryotic
cells.
To
address
this
issue,
herein,
named
BDTP
with
aggregation‐induced
emission
properties
was
developed.
can
specifically
target
DNA
but
integrate
into
cell
membrane,
preventing
damage
contents
in
cells
due
its
hydrophilic/lipophilic
“Y‐shaped”
structural
characteristics.
In
dark
conditions,
functions
antibiotic,
inhibiting
bacterial
proliferation.
Upon
white
light
stimulation,
induce
phototoxic
effectively
inhibit/clear
Additionally,
significantly
reduces
PS‐induced
nucleic
acids.
This
promotes
healing
infected
wounds
‐infected
mice.
Our
work
introduces
first
targeting
‐associated
infections,
demonstrating
efficacy
both
vitro
vivo.
