Thienylquinoline-Based Ionic Iridium(III) Complexes as Highly Efficient Sonosensitizers for Sonodynamic Therapy

Journal of Organometallic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 123547 - 123547

Published: Jan. 1, 2025

Language: Английский

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Ultrasound‐Triggered Cascade Delivery via Poly‐Oxaliplatin Nanoparticles for Immunotherapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Abstract Oxaliplatin (OXA), a third‐generation platinum‐based chemotherapeutic agent, is widely utilized in cancer treatment due to its potent cytotoxic effects and ability induce immunogenic cell death (ICD). However, the clinical application of OXA significantly hindered by inefficient drug delivery. To address these challenges, cascade delivery system that integrates ultrasound (US) activation with Poly‐Oxaliplatin nanoparticles (OXA‐Ce6 NP) developed enhance therapeutic efficacy overcome resistance mechanisms OXA. This sono‐responsive platform consists an amphiphilic polymer incorporating OXA(IV) prodrug (Poly‐OXA(IV)) sonosensitizer chlorin e6 (Ce6), enabling US‐triggered cascade. Upon US exposure, this facilitates 1) enhanced cellular uptake via increased membrane permeability, 2) situ through electron transfer, 3) augmented formation OXA‐DNA adducts, thereby intensifying DNA damage effects. Moreover, US‐induced reactive oxygen species (ROS) further potentiate ICD, remodeling tumor immune microenvironment promoting systemic antitumor immunity. By leveraging as external stimulus, enhances outcome while mitigating toxicity. strategy provides versatile approach optimizing chemotherapy integrating immunotherapy, offering promising avenue for improving treatments.

Language: Английский

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Advanced cavitation agents: A comprehensive review of micro/nano-sonocatalysts and sonosensitizers

BME Frontiers, Journal Year: 2024, Volume and Issue: 5

Published: Jan. 1, 2024

Sonodynamic therapy (SDT) has emerged as a novel and highly researched advancement in the medical field. Traditional ultrasound contrast agents bubble-shaped are used to stimulate cavitation enhance SDT efficiency. However, impact of artificially modified shell structures on acoustic properties microbubbles remains be explored. Alternatively, absence agents, some clinically available organic sonosensitizers advanced inorganic materials also efficacy SDT. Diagnostic therapeutic can activate bubbles, which supply energy sonosensitive leading production cytotoxic free radicals achieve effects. While often spark controversy clinical applications, their relatively simple structure enables researchers gain insight into mechanism by produces various radicals. Some organic–inorganic hybrid systems have been reported, combining benefits agents. employing cell surface modification engineering enable cells perform functions such immune escape, drug loading, gas sonosensitivity, cellular developed. further exploration is needed properties, ability generate reactive oxygen species (ROS), potential application this sonosensitizer. This review offers comprehensive analysis vesical nanoscale sonocatalysts, including organic, inorganic, combined sonosensitizers, sonosensitizers. will our understanding demonstrate its important transforming applications.

Language: Английский

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Rational Design of Chloride-Based Ionic Iridium(III) Complex to Construct Phosphorescent Nanoparticles for Cancer Cell Imaging

Journal of Organometallic Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 123485 - 123485

Published: Dec. 1, 2024

Language: Английский

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