Lithium Bond‐Mediated Molecular Cascade Hydrogel for Injury‐Free and Repositionable Adhesive Bioelectronic Interfaces

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Abstract Flexible bioelectronic interfaces with adhesive properties are essential for advancing modern medicine and human‐machine interactions. However, achieving both stable adhesion non‐damaging detachment remains a significant challenge. In this study, lithium bond‐mediated molecular cascade hydrogel (LMCH) is designed, which facilitates robust at the tissue level permits atraumatic repositioning as required. By integrating of structure elastic characteristics interface, LMCH interface not only achieved high strength (197 J m −2 ) on skin, but also significantly extended cracking cycles surface during peeling process from 4 to 380, marking an enhancement nearly two orders magnitude. Furthermore, Young's modulus similar that human (25 kPa), exceptional stretchability (1080%), ionic conductivity (7.14 S −1 ), demonstrates outstanding compatibility, biocompatibility, detection capabilities electrocardiogram (ECG) electromyogram (EMG) signals. This study presents new insights potential bioelectronics implantable technologies.

Language: Английский

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Tissue‐Adhesive and Stiffness‐Adaptive Neural Electrodes Fabricated Through Laser‐Based Direct Patterning

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Recently, implantable devices for treating peripheral nerve disorders have demonstrated significant potential as neuroprosthetics diagnostics and electrical stimulation. However, the mechanical mismatch between these nerves frequently results in tissue damage performance degradation. Although advances are made stretchable electrodes, challenges, including complex patterning techniques unstable performance, persist. Herein, an efficient method developing a tissue‐adhesive, stiffness‐adaptive neural interface (TA‐SA‐PNI) is presented employing mechanically electrically stable ultrathin conductive micro/nanomembrane bilayer (UC‐MNB) electrodes. A direct laser‐patterning technique utilized to anchor UC‐MNB, comprising Cu micromembrane encapsulated by biocompatible Au nanomembrane, onto tough self‐healing polymer (T‐SHP) substrate using thermoplastic properties of T‐SHP. The UC‐MNB with wavy structure exhibited strain‐insensitive under strains up 60%. Furthermore, its dynamic stress‐relaxation enable stiffness adaptation, potentially minimizing chronic compression. Finally, phenylboronic acid‐conjugated alginate (Alg‐BA) adhesive layer offers adhesion ionic conductivity, optimizing TA‐SA‐PNI seamless integration into applications. Leveraging advantages, vivo demonstrations bidirectional pathways successfully conducted, featuring measurements sensory signals feedback stimulation sciatic rats.

Language: Английский

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Wet adhesives for hard tissues

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Benign separated cellulose adhesive hydrogel via constructing double dynamic covalent bonds for ultra-fast hemostasis and antibacterial

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160665 - 160665

Published: Feb. 1, 2025

Language: Английский

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Shape-Adaptive, Deformable and Adhesive Hydrogels Enable Stable Closure of Long Incision Wounds

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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A facilely prepared dual-crosslinking adhesive with enhanced adhesive strength for hemostasis and infected wound healing

Biomaterials Advances, Journal Year: 2025, Volume and Issue: unknown, P. 214349 - 214349

Published: May 1, 2025

Language: Английский

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4D-printable photocurable pressure sensitive adhesives derived from waste cooking oil

Virtual and Physical Prototyping, Journal Year: 2025, Volume and Issue: 20(1)

Published: May 18, 2025

Language: Английский

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