Ultrasensitive Detection of Chemokines in Clinical Samples with Graphene‐Based Field‐Effect Transistors DOI Creative Commons
David A. Kaiser, Nikolaus Meyerbroeker,

Werner G. Purschke

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(52)

Published: Nov. 20, 2024

Due to their ultra-high sensitivity, solution-gated graphene-based field-effect transistors (SG-GFET) have been proposed for applications in bio-sensing. However, challenges regarding the functionalization of GFETs prevented clinical diagnostics so far. Here GFET sensors based on van der Waals (vdW) heterostructures single-layer graphene layered with a molecular ≈1 nm thick carbon nanomembrane (CNM) are presented. The CNM acts as an ultrathin interposer between channel and analyte allows bio-functionalization without impairing properties including its charge carrier mobility. To achieve specificity reliability detection biomarkers real patient samples, incorporates biostable aptamers non-natural l-configuration hydrophilic polyethylene glycol avoiding non-specific adsorption. A rapid (≈5 min) clinically relevant inflammatory mediator CXCL8/IL-8 within concentration range 0.5 - 500 pM (5 5000 pg ml-1) is demonstrated nasal swab samples collected from patients respiratory tract infections. This may aid early-stage infectious diseases making reported approach promising development future medical tools.

Language: Английский

Carborane Nanomembranes DOI Creative Commons
Martha Frey, Julian Picker, Christof Neumann

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

We report on the fabrication of a boron-based two-dimensional (2D) material via electron irradiation-induced cross-linking carborane self-assembled monolayers (SAMs) crystalline silver substrates. The SAMs 1,2-dicarba-closo-dodecarborane-9,12-dithiol (O9,12) were prepared flat substrates and irradiated with low-energy electrons, resulting in 2D nanomembrane. mechanical stability compact character nanomembrane improved by using 12-(1′,12′-dicarba-closo-dodecarboran-1′-yl)-1,12-dicarba-closo-dodecarborane-1-thiol (1-HS-bis-pCB), longer, rod-like SAM precursor two para-carborane units linked linearly together. self-assembly, process, transfer membranes onto holey characterized different complementary surface-sensitive techniques including X-ray photoelectron spectroscopy (XPS), ultraviolet (UPS), diffraction (LEED) as well scanning tunneling microscopies (STM, SEM) to provide insight structural changes within cross-linked SAMs. presented methodology has potential for development materials applications electronic optical devices.

Language: Английский

Citations

0
Small-Data Gesture Recognition Using Bending-Sensitive Graphene Strain Sensors and Diffractive Deep Neural Networks DOI

瑾 李

Modeling and Simulation, Journal Year: 2025, Volume and Issue: 14(05), P. 67 - 82

Published: Jan. 1, 2025

Language: Английский

Citations

0
Ultrasensitive Detection of Chemokines in Clinical Samples with Graphene‐Based Field‐Effect Transistors DOI Creative Commons
David A. Kaiser, Nikolaus Meyerbroeker,

Werner G. Purschke

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(52)

Published: Nov. 20, 2024

Due to their ultra-high sensitivity, solution-gated graphene-based field-effect transistors (SG-GFET) have been proposed for applications in bio-sensing. However, challenges regarding the functionalization of GFETs prevented clinical diagnostics so far. Here GFET sensors based on van der Waals (vdW) heterostructures single-layer graphene layered with a molecular ≈1 nm thick carbon nanomembrane (CNM) are presented. The CNM acts as an ultrathin interposer between channel and analyte allows bio-functionalization without impairing properties including its charge carrier mobility. To achieve specificity reliability detection biomarkers real patient samples, incorporates biostable aptamers non-natural l-configuration hydrophilic polyethylene glycol avoiding non-specific adsorption. A rapid (≈5 min) clinically relevant inflammatory mediator CXCL8/IL-8 within concentration range 0.5 - 500 pM (5 5000 pg ml-1) is demonstrated nasal swab samples collected from patients respiratory tract infections. This may aid early-stage infectious diseases making reported approach promising development future medical tools.

Language: Английский

Citations

3