Perovskite‐Graphene Heterostructure Biosensor Integrated with Biotunable Nanoplasmonic Ternary Logic Gate for Ultrasensitive Cytokine Detection DOI Creative Commons
Jiaxing Sun, Lin Zhou, Zening Li

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 21, 2025

Abstract The integration of 2D‐materials and optoelectronic devices has attracted great attention for advanced applications. We propose the first perovskite/graphene heterostructure‐based FET biosensor with uniquely biotunable ternary logic gating functionality. integrates a lateral perovskite‐on‐graphene heterostructure phototransistor vertical bio‐nano‐photonic filter, decoupled construction inset. In phototransistor, photoactive perovskite quantum dots (PQDs) serve as sensitizers to absorb light while high mobility single‐layer graphene (SLG) acts an expressway carrier transport. localized surface plasmon resonance (LSPR) is induced by gold nanoparticles (AuNPs) in conjunction antigen‐antibody binding, tuning delivery passing through filter facilitating functionality modes. set up detect human interleukin‐6 (IL6) order determine achieve ultrahigh sensitivity limit detection (LOD) 0.9 fg mL −1 (43 aM), which 4 orders magnitude greater than graphene‐FET biosensors. This achieved due synergistic effect PQDs/SLG heterostructure, exhibiting superior electrical, optical, physicochemical properties, consequently providing significantly performance terms label‐free, (attomolar level), rapid responsivity (5 min), excellent stability, selectivity. configuration could open new avenue 2D materials realm next‐generation platforms applications healthcare, early diagnosis, detection.

Language: Английский

Ultrasensitive Detection of Chemokines in Clinical Samples with Graphene‐Based Field‐Effect Transistors DOI Creative Commons
David A. Kaiser, Nikolaus Meyerbroeker,

Werner G. Purschke

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(52)

Published: Nov. 20, 2024

Due to their ultra-high sensitivity, solution-gated graphene-based field-effect transistors (SG-GFET) have been proposed for applications in bio-sensing. However, challenges regarding the functionalization of GFETs prevented clinical diagnostics so far. Here GFET sensors based on van der Waals (vdW) heterostructures single-layer graphene layered with a molecular ≈1 nm thick carbon nanomembrane (CNM) are presented. The CNM acts as an ultrathin interposer between channel and analyte allows bio-functionalization without impairing properties including its charge carrier mobility. To achieve specificity reliability detection biomarkers real patient samples, incorporates biostable aptamers non-natural l-configuration hydrophilic polyethylene glycol avoiding non-specific adsorption. A rapid (≈5 min) clinically relevant inflammatory mediator CXCL8/IL-8 within concentration range 0.5 - 500 pM (5 5000 pg ml-1) is demonstrated nasal swab samples collected from patients respiratory tract infections. This may aid early-stage infectious diseases making reported approach promising development future medical tools.

Language: Английский

Citations

5
Carborane Nanomembranes DOI Creative Commons
Martha Frey, Julian Picker, Christof Neumann

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

We report on the fabrication of a boron-based two-dimensional (2D) material via electron irradiation-induced cross-linking carborane self-assembled monolayers (SAMs) crystalline silver substrates. The SAMs 1,2-dicarba-closo-dodecarborane-9,12-dithiol (O9,12) were prepared flat substrates and irradiated with low-energy electrons, resulting in 2D nanomembrane. mechanical stability compact character nanomembrane improved by using 12-(1′,12′-dicarba-closo-dodecarboran-1′-yl)-1,12-dicarba-closo-dodecarborane-1-thiol (1-HS-bis-pCB), longer, rod-like SAM precursor two para-carborane units linked linearly together. self-assembly, process, transfer membranes onto holey characterized different complementary surface-sensitive techniques including X-ray photoelectron spectroscopy (XPS), ultraviolet (UPS), diffraction (LEED) as well scanning tunneling microscopies (STM, SEM) to provide insight structural changes within cross-linked SAMs. presented methodology has potential for development materials applications electronic optical devices.

Language: Английский

Citations

0
Small-Data Gesture Recognition Using Bending-Sensitive Graphene Strain Sensors and Diffractive Deep Neural Networks DOI

瑾 李

Modeling and Simulation, Journal Year: 2025, Volume and Issue: 14(05), P. 67 - 82

Published: Jan. 1, 2025

Language: Английский

Citations

0
Multiplexed Detection of Pancreatic-Specific Nucleic Acids and Protein Biomarkers Using a Logic Nanofluidic Platform DOI
Lina Wang, Yuanyuan Jia, Jin Wang

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

Early detection of pancreatic cancer is vital for patient survival. However, current diagnostic approaches remain constrained by insufficient precision and specificity inherent to single-biomarker strategies. Herein, we develop a nanochannel biosensing platform implementing cooperative dual-signal pancreatic-specific biomarkers CA19-9 miRNA-196a. Using liquid-liquid interface self-assembly, constructed anodic aluminum oxide (AAO)-Au hybrid nanochannels integrated with surface-modified double-key DNA nanolock (DDN). The conformational switch DDN logic gating triggered miRNA-196a exposes the CA19-9-aptamer, enabling specific target recognition consequent ion signal attenuation. Simultaneously, released quantified catalytic hairpin assembly hybridization chain reaction-mediated cascade amplification. Experiments show that present DDN-based nanofluidic could achieve an ultralow limit 0.000027 U·mL-1 4.74 aM miRNA-196a, which 2-3 orders magnitude higher than traditional ELISA/qPCR methods. Finally, clinical sample analysis confirms high this in distinguishing acute pancreatitis from healthy individuals. This DDN-functionalized biosensor provides valuable insights into designing platforms cancer, highlighting its significant potential diagnostics.

Language: Английский

Citations

0
Perovskite‐Graphene Heterostructure Biosensor Integrated with Biotunable Nanoplasmonic Ternary Logic Gate for Ultrasensitive Cytokine Detection DOI Creative Commons
Jiaxing Sun, Lin Zhou, Zening Li

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 21, 2025

Abstract The integration of 2D‐materials and optoelectronic devices has attracted great attention for advanced applications. We propose the first perovskite/graphene heterostructure‐based FET biosensor with uniquely biotunable ternary logic gating functionality. integrates a lateral perovskite‐on‐graphene heterostructure phototransistor vertical bio‐nano‐photonic filter, decoupled construction inset. In phototransistor, photoactive perovskite quantum dots (PQDs) serve as sensitizers to absorb light while high mobility single‐layer graphene (SLG) acts an expressway carrier transport. localized surface plasmon resonance (LSPR) is induced by gold nanoparticles (AuNPs) in conjunction antigen‐antibody binding, tuning delivery passing through filter facilitating functionality modes. set up detect human interleukin‐6 (IL6) order determine achieve ultrahigh sensitivity limit detection (LOD) 0.9 fg mL −1 (43 aM), which 4 orders magnitude greater than graphene‐FET biosensors. This achieved due synergistic effect PQDs/SLG heterostructure, exhibiting superior electrical, optical, physicochemical properties, consequently providing significantly performance terms label‐free, (attomolar level), rapid responsivity (5 min), excellent stability, selectivity. configuration could open new avenue 2D materials realm next‐generation platforms applications healthcare, early diagnosis, detection.

Language: Английский

Citations

0