Acta Pharmacologica Sinica, Journal Year: 2025, Volume and Issue: unknown
Published: June 4, 2025
Language: Английский
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 20, 2025
Abstract Non‐surgical and safe prostate cancer (PCa) therapies are in demand. Soluble tumor necrosis factor (TNF‐α) related apoptosis inducing ligand (TRAIL), a cancer‐specific drug, shows preclinical efficacy but has short circulation half‐life. This research shown that physiological fluid shear stress activates mechanosensitive ion channels (MSCs), such as Piezo1, enhancing TRAIL‐mediated cells. Herein, noninvasive, focal ultrasound (FUS) is implemented to augment the pro‐apoptotic effects of TRAIL. Using thermally FUS parameters, it observed TRAIL sensitivity increases with higher pressure PCa cells, mediated by Piezo1. confirmed examining calcium chelation, MSC inhibitors, PIEZO knockdown. In vivo, multi‐dose study 10 min exposure 0 4‐h intervals between significantly reduce burden, an increase evident enhanced cleaved‐caspase 3 expression. mechanotherapy offers clinically translatable approach utilizing widely available technology, applicable treat additional types.
Language: Английский
Citations
0
Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)
Published: Feb. 26, 2025
Abstract The battle against cancer has evolved over centuries, from the early stages of surgical resection to contemporary treatments including chemotherapy, radiation, targeted therapies, and immunotherapies. Despite significant advances in treatment recent decades, these therapies remain limited by various challenges. Immune checkpoint inhibitors (ICIs), a cornerstone tumor immunotherapy, have emerged as one most promising advancements treatment. Although ICIs, such CTLA-4 PD-1/PD-L1 inhibitors, demonstrated clinical efficacy, their therapeutic impact remains suboptimal due patient-specific variability immune resistance. Cell death is fundamental process for maintaining tissue homeostasis function. Recent research highlights that combination induced regulatory cell (RCD) ICIs can substantially enhance anti-tumor responses across multiple types. In cells exhibiting high levels recombinant solute carrier family 7 member 11 (SLC7A11) protein, glucose deprivation triggers programmed (PCD) pathway characterized disulfide bond formation REDOX (reduction-oxidation) reactions, termed “disulfidptosis.” Studies suggest disulfidptosis plays critical role efficacy SLC7A11 cancers. Therefore, investigate potential synergy between this study will explore mechanisms both processes progression, with goal enhancing response targeting intracellular pathway.
Language: Английский
Citations
0
Cancer Communications, Journal Year: 2025, Volume and Issue: unknown
Published: April 10, 2025
Abstract Cancer immunotherapy offers renewed hope for treating this disease. However, cancer cells possess inherent mechanisms that enable them to circumvent each stage of the immune cycle, thereby evading anti‐cancer immunity and leading resistance. Various functionalized nanoparticles (NPs), modified with cationic lipids, pH‐sensitive compounds, or photosensitizers, exhibit unique physicochemical properties facilitate targeted delivery therapeutic agents tumor microenvironment (TME). These NPs are engineered modify activity. The crucial signal transduction pathways by which counteract resistance outlined, including enhancing antigen presentation, boosting activation infiltration tumor‐specific cells, inducing immunogenic cell death, counteracting immunosuppressive conditions in TME. Additionally, review summarizes current clinical trials involving NP‐based immunotherapy. Ultimately, it highlights potential nanotechnology advance
Language: Английский
Citations
0
Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown
Published: May 22, 2025
Intense oxidative stress in bone tissues can trigger the hyperactivation of neutrophils, thereby causing inflammatory cascades to deteriorate homeostasis. Here, inspired by catalytic centers natural antioxidases, we introduce spatial configuration-guided design covalent organic framework (COF)-based artificial metalloantioxidases for inhibiting and regulating Specifically, hexaiminohexaazatrinaphthalene COF with ruthenium coordination (S-HACOF-Ru), featuring electron-rich a configuration, demonstrates exceptional antioxidase-like reactive oxygen species (ROS) scavenging capabilities efficiently mitigating stress. As result, S-HACOF-Ru prevents generation neutrophil extracellular traps inhibits release myeloperoxidase (MPO). By preventing MPO-induced activation nuclear factor-kappa B proinflammatory macrophage polarization, successfully blocks neutrophil-macrophage cascades. This intervention promotes homeostasis shift from resorption tissue regeneration, which inhibit alveolar loss periodontal reverse cartilage damage ankle joint cavities. We propose that this strategy provides an intriguing avenue developing new antioxidases biocatalytic materials potential applications treating wide range chronic diseases.
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: June 1, 2025
Abstract The chronic inflammatory milieu of rheumatoid arthritis (RA), marked by elevated reactive oxygen species (ROS), perpetually activated pro‐inflammatory macrophages (M1) and osteoclasts, significant infiltration cytokines contributes to abnormal articular redox imbalance, severe synovitis, progressive joint erosion. In this study, the rational design a biocatalytic redox‐regulated nanoarchitecture comprising Ru cluster‐anchored hydroxylated Fe 2 O 3 (Ru‐HFO) encapsulated within bone marrow stem cell‐derived extracellular vesicles (BEVs), for precision inflammation modulation combat RA is proposed. When combined with ultrasound (US) stimulation, inflammation‐targeting (BEVs@Ru‐HFO) can reprogram osteoclasts restore immune homeostasis, thereby alleviating RA. findings reveal that hydroxylation strategy enhances electron density at centers fine‐tunes binding affinity intermediates, ensuring exceptional multi‐enzymatic ROS‐scavenging activities. Notably, under ultrasonic irradiation, BEVs@Ru‐HFO targets inflamed joints, promotes local accumulation anti‐inflammatory macrophages, downregulates cytokines, ameliorates hypoxic microenvironment inhibit osteoclastogenesis. This ultimately confers cartilage protection restores function. It posit nanoarchitecture, its superior antioxidant immunomodulatory capabilities, represents promising engineering ROS‐catalytic materials treat potentially many other autoimmune diseases.
Language: Английский
Citations
0
Acta Pharmacologica Sinica, Journal Year: 2025, Volume and Issue: unknown
Published: June 4, 2025
Language: Английский
Citations
0