Machine learning-assisted mid-infrared spectrochemical fibrillar collagen imaging in clinical tissues
Wihan Adi,
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Bryan E. Rubio Perez,
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Yuming Liu
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et al.
Journal of Biomedical Optics,
Journal Year:
2024,
Volume and Issue:
29(09)
Published: Sept. 27, 2024
Label-free
multimodal
imaging
methods
that
can
provide
complementary
structural
and
chemical
information
from
the
same
sample
are
critical
for
comprehensive
tissue
analyses.
These
specifically
needed
to
study
complex
tumor-microenvironment
where
fibrillar
collagen's
architectural
changes
associated
with
cancer
progression.
To
address
this
need,
we
present
a
computational
method
mid-infrared
spectral
(MIRSI)
is
employed
second
harmonic
generation
(SHG)
microscopy
identify
collagen
in
biological
tissues.
Language: Английский
3D-architected gratings for polarization-sensitive, nature-inspired structural color
Mauricio Miranda,
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Lars Osterberg,
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Dev Narayan Shah
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et al.
Nanophotonics,
Journal Year:
2025,
Volume and Issue:
14(5), P. 547 - 558
Published: March 1, 2025
Abstract
Structural
coloration,
a
color-generation
mechanism
often
found
in
nature,
arises
from
light–matter
interactions
such
as
diffraction,
interference,
and
scattering,
with
micro-
nanostructured
elements.
Herein,
we
systematically
study
anisotropic,
3D-architected
grating
structures
polarization-tunable
optical
properties,
inspired
by
the
vivid
blue
of
Morpho
butterfly
wings.
Using
two-photon
lithography,
fabricate
multilayered
gratings,
varying
parameters
height
(through
scanning
speed
laser
power),
periodicity,
number
layers.
In
transmission,
significant
color
transitions
to
brown
were
identified
when
structural
incident
light
polarization
conditions
(azimuthal
angle
ellipticity).
Based
on
thin
film
diffraction
efficiency
theory
Raman–Nath
regime,
characterization
results
are
analytically
explained,
evaluating
impact
each
parameter
variation.
Overall,
these
findings
contribute
technological
implementations
polarization-sensitive,
gratings
for
applications.
Language: Английский