Multifunctional dynamic chitosan-guar gum nanocomposite hydrogels in infection and diabetic wound healing

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123316 - 123316

Published: Jan. 1, 2025

Language: Английский

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Autonomous, Moisture‐Driven Flexible Electrogenerative Dressing for Enhanced Wound Healing

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Abstract Electrotherapy has shown considerable potential in treating chronic wounds, but conventional approaches relying on bulky external power supplies and mechanical force are limited their clinical utility. This study introduces an autonomous, moisture‐driven flexible electrogenerative dressing (AMFED) that overcomes these limitations. The AMFED integrates a moist‐electric generator (MEG), antibacterial hydrogel dressing, concentric molybdenum (Mo) electrodes to provide self‐sustaining electrical supply potent activity against Staphylococcus aureus Escherichia coli . MEG harnesses chemical energy from moisture produce stable direct current of 0.61 V without input, delivering this therapeutic stimulation the wound site through Mo electrodes. facilitates macrophage polarization toward reparative M2 phenotype regulates inflammatory cytokines. Moreover, vivo studies suggest group significantly enhances healing, with approximate 41% acceleration compared control group. Using diabetic mouse model, demonstrates its effectiveness promoting nerve regulation, epithelial migration, vasculogenesis. These findings present novel efficient platform for accelerating healing.

Language: Английский

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Intrinsically Adhesive and Conductive Hydrogel Bridging the Bioelectronic–Tissue Interface for Biopotentials Recording

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

Achieving high-quality biopotential signal recordings requires soft and stable interfaces between tissues bioelectronic devices. Traditional bioelectronics, typically rigid dependent on medical tape or sutures, lead to mechanical mismatches inflammatory responses. Existing conducting polymer-based bioelectronics offer tissue-like softness but lack intrinsic adhesion, limiting their effectiveness in creating stable, conductive interfaces. Here, we present an intrinsically adhesive hydrogel with a modulus strong adhesion various substrates. Adhesive catechol groups are incorporated into the poly(3,4-ethylenedioxythiophene) (PEDOT) matrix, which reduces PEDOT size improves dispersity form percolating network excellent electrical conductivity strain insensitivity. This effectively bridges bioelectronics–tissue interface, ensuring pristine minimal interference from bodily movements. capability is demonstrated through comprehensive vivo experiments, including electromyography electrocardiography both static dynamic human skin electrocorticography moving rats. represents significant advancement for interfaces, facilitating more accurate less intrusive diagnostics.

Language: Английский

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ROS sensitive adaptive injectable hydrogels Based on GAPBA nanofibers and PVA/EGCG for accelerating diabetic wound healing through regulating the inflammation microenvironment

European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113723 - 113723

Published: Jan. 1, 2025

Language: Английский

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Polyphenol-enhanced wet adhesive hydrogel with synergistic mechanical activation and ROS scavenging for accelerating diabetic wound healing

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 157103 - 157103

Published: Oct. 1, 2024

Language: Английский

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Hydrogel Fibers‐Based Biointerfacing

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

Abstract The unique 1D structure of fibers offers intriguing attributes, including a high length‐to‐diameter ratio, miniatured size, light‐weight, and flexibility, making them suitable for various biomedical applications, such as health monitoring, disease treatment, minimally invasive surgeries. However, traditional fiber devices, typically composed rigid, dry, non‐living materials, are intrinsically different from the soft, wet, living essence biological tissues, thereby posing grand challenges long‐term, reliable, seamless interfacing with systems. Hydrogel have recently emerged promising candidate, in light their similarity to tissues mechanical, chemical aspects, well distinct geometry. In this review, comprehensive overview recent progress hydrogel fibers‐based biointerfacing technology is provided. It thoroughly summarizes manufacturing strategy functional design, especially optical electron conductive performance, responsiveness triggers thermal, magnetic field ultrasonic wave, etc. Such attributes enable which also examined detail. Future potential directions, biosafety, long‐term reliability, sterilization, multi‐modalities integration intelligent therapeutic systems, raised. This review will serve valuable resource further advancement implementation next‐generation technology.

Language: Английский

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In-situ trichosanthin-IL2/pectin dynamic hydrogel activates dendritic cells and reverses T cell exhaustion for post-operative cancer therapy

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 505, P. 159426 - 159426

Published: Jan. 8, 2025

Language: Английский

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Phototropic self-growing hydrogels based on a tricyanofuran derivatized photoswitch

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Phototropism is ubiquitous in plants that endows them directional movement and substantial growth toward light sources. Simultaneous replication of such phototropic volumetric synthetic polymers important but currently remains challenging. Here, we report the molecular design a photoswitchable tricyanofuran (TCF) based hydrogel can concurrently display self-growth water under stimulation pH. The macroscale hdyrogel originates directly from charge rise TCF switch upon isomerization induced by or pH, which dramatically improves polymer hydrophilicity facilicates diffusion into network. As growing rate each independently regulated, successfully developed hydrogels displaying heterogeneous accompanied with bending deformation taking advantage differential rates Importantly, direction during process be flexibly switched to either positive negative tuning irradiation pH conditions for applications replicating structure function natural light-responsive systems. Our work provides novel strategy advancing development biomimetic systems capability self-growth.

Language: Английский

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Hybrid hydrogel based on porcine-derived matrix with gallic acid and cerium-doped mesoporous bioactive glass for diabetic wound healing

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113714 - 113714

Published: Feb. 1, 2025

Language: Английский

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Endoscopic Delivery of a Double-Umbrella-Shaped Hydrogel Occluder with Instant Mechanical Interlock and Robust Wet Adhesion for Gastric Perforation Repair

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Achieving robust adhesion of bioadhesives on wet tissues to block gastric perforation remains a challenge due the gradually deteriorated adhesive-tissue interactions by interfacial acidity and multienzyme fluids, thus accompanying failure shedding life-threatening risks. Here, we report biocompatible double-umbrella-shaped endoscopy-deliverable hydrogel occluder (EHO) made caffeic acid (CA)-grafted chitosan (CS) polyacrylamide (PAM) molding technique, which is capable customizable, rapid, robust, long-term sealing large perforations. In addition physiochemical (e.g., H-bonding, chelation) between polymers, efficient also integrates advantages fast mechanical interlocking in space gradual self-expansion over time tolerant acidic mechanically dynamic environments. The EHO exhibits favorable biodegradability reducible disulfide cross-linkers remarkable protective barrier functions impede infiltration digestive pepsin into wound. To validate EHO's therapeutic efficacy, further demonstrate vivo via endoscopic delivery porcine stomach monitor healing process with improved retention endogenous growth factors. Besides, views simple fabrication using biodegradable can be facilely tailored various topologies according application scenarios surgical minimally invasive delivery, offering promising alternative for clinical repair gastrointestinal perforations other organs.

Language: Английский

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