Electrically controlled on-demand wound therapy based on real-time pH monitoring

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162522 - 162522

Published: April 1, 2025

Language: Английский

---

Nanoscale Cuttlebone-doped PVA/SA Hydrogel with Hemostatic and Antibacterial Properties

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 252, P. 114703 - 114703

Published: April 12, 2025

Language: Английский

---

Mechanism underlying the involvement of CXCR4/CXCL12 in diabetic wound healing and prospects for responsive hydrogel-loaded CXCR4 formulations

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 16, 2025

Diabetes mellitus is a prevalent chronic disease, often leading to complications, with wounds being among the most challenging. Impairment of CXCR4/CXCL12 signaling pathway, which plays key role in cell mobilization, migration, and angiogenesis, significantly hampers wound healing process diabetic patients. Modulation this pathway using CXCR4-targeted agents has shown promise restoring repair capabilities. Additionally, development responsive hydrogels capable adapting external stimuli offers powerful platform for drug delivery management. These hydrogels, when loaded CXCR4 agonists or antagonists, enable controlled release real-time therapeutic modulation. Integrating such existing strategies may provide an innovative effective solution overcoming challenges associated treatment.

Language: Английский

---

Conductive Hydrogels with Topographical Geometry and Mechanical Robustness for Enhanced Peripheral Nerve Regeneration

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Nerve guidance conduits (NGCs) emerge as a promising solution for nerve regeneration; however, conventional NGCs fail to fulfill the requirements peripheral regeneration, which are subjected periodical yet vigorous stretching, bending, and compression. Here, we developed fatigue-resistant conductive hydrogel-based NGC by integrating topographical geometry, enhanced electroactivity, superior fatigue resistance within one unit. The hydrogel, consisting of PVA matrix with PEDOT:PSS filler, features alignment that promotes axonal growth achieves threshold over 500 J/m2, making it well-suited sciatic repairing. Phase segregation PEDOT chains enhances its electrical conductivity (>500 S/m) mitigates interfacial impedance mismatch, allowing high-efficiency bioelectrical signal transmission. In vivo studies on rat injury model corroborate accelerated regeneration through improved motor function recovery efficient electrophysiological These findings establish our synergy topographical, mechanical, engineering.

Language: Английский

---

Fabrication of Janus‐adhesion Multifunctional Hydrogel Based on β‐cyclodextrin for Wound Dressing

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Abstract Conventional wound dressings frequently face challenges of insufficient mechanical strength, inadequate adhesion, irregular drug release, and contamination from adherence to extraneous surfaces. These issues can lead the risk secondary injuries. In this work, a robust, thermoresponsive dressing is developed based on pH/thermal‐responsive supramolecular hydrogels, synthesized by integrating N‐isopropyl acrylamide, carboxymethyl cellulose, β‐cyclodextrin‐grafted poly(acrylic acid). The novel finding that hydrogel exhibits Janus‐like wherein it adheres stably while losing adhesion external environments resulting in reduced accumulation impurities. prepared hydrogels self‐heal at low temperatures. It has antioxidant properties excellent biocompatibility continuously release active medicines. vivo experiments rat model full‐thickness skin wounds show positively accelerate healing. unique physicochemical biological interactions multifunctional provide promise for advancing management modulating tissue adhesion.

Language: Английский

---

The versatile nanocomposite wound dressing with zinc replenishment, and enhanced photothermal and fluorescent performance for accelerating methicillin-resistant staphylococcus aureus-infected diabetic wound repair and indicating dressing replacement

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 696, P. 137867 - 137867

Published: May 11, 2025

Language: Английский

---

Co-initiating-system dual-mechanism drives the design of printable entangled polymer multinetworks

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: May 12, 2025

Entanglement significantly enhances the mechanical performance and functionality of both natural synthetic materials. However, developing straightforward, versatile strategies for creating high-performance entangled polymer materials remains a challenge. Here, co-initiating-system dual-mechanism strategy is designed fabricating printable multinetworks. This thermal-light dual-initiation process benefits synthesis high-molecular-weight polymers promotes rapid formation multinetworks within hydrogels. The resulting long chains enable hydrogels with higher performance, lower stress relaxation, activation energy compared to short chain-contained samples. Such method proves more effective than traditional self-thickening strengthening techniques enhancing hydrogel entanglements also compatible additive manufacturing, enabling design complex 2D webs adaptive capable detecting sensing applications. work provides an designing materials, which are set impact numerous fields, from advanced material science beyond.

Language: Английский

---

Biomimetic Dual-Layer Architectural Hydrogel Bandage with Smart Thermally Self-Contraction for Enhanced Wound Closure and Burn Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

Severe burn injuries disrupt cutaneous barrier integrity, leading to elevated infection susceptibility, substantial fluid loss, and delayed tissue regeneration, which collectively deteriorate patient outcomes. While early stage wound closure is critical for mitigating these complications, current hydrogel dressings often lack dynamic contractile properties synergistically facilitate both physical biological healing. Inspired by the mechanobiology of embryonic contraction, we develop a nested poly(N-isopropylacrylamide)-sodium alginate bandage (PNS-HB) featuring biomimetic dual-layer architecture. The outer layer comprises polydopamine-poly(acrylic acid) (PDA-PAA) adhesive framework, enabling tissue-conformal fixation (interfacial toughness 162 J/m2; Young's modulus 45 kPa; fracture strain 85%). inner thermoresponsive PNS-HB exhibiting excellent mechanical flexibility (Young's 9.9-16.7 kPa) programmable shape-morphing capabilities, including temperature-dependent bending (118° angle) contraction (contraction rate 56%). In deep second-degree model, demonstrated three-stage therapeutic mechanism: thermally triggered edge through generation, inflammatory modulation downregulation IL-6 TNF-α (>60% reduction), pro-regenerative microenvironment establishment evidenced accelerated angiogenesis re-epithelialization. This architecture offers paradigm-shifting approach bridging gap between restoration in care.

Language: Английский

---

Mechanics Mediated Semi‐Convertible Hydrogel Enabled Sustained Drug Release

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 22, 2025

Abstract The dynamic mechanic environment surrounding the wound may retard healing, and even lead to an exacerbation of inflammation scar. How actively promote healing under a mechanical during human motion is still long‐standing challenge. Therefore, mechanics mediated semi‐convertible hydrogel (M ech SCH) loaded with drug proposed in this study employing synergistic interaction between supramolecular non‐covalent networks polyvinyl alcohol/Gelatin polymer for enhancing healing. formed M SCH exhibits partial gel‐sol transition shear stress ≈9.04 Pa that satisfied most tissues or organs' stress. sustained release encapsulated drugs would be efficiently compared non‐sensitive hydrogel. platelet‐derived growth factor (PDGF) exhibited rapid onset therapeutic effect mice dorsal full‐thickness dermal model, which demonstrated sustaining through skin tension at site, along alleviating promoting vascular regeneration. This presents potential clinical applications management chronic wounds.

Language: Английский

---

Recent Advances in Multifunctional Naturally Derived Bioadhesives for Tissue Engineering and Wound Management

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(12)

Published: Dec. 1, 2024

ABSTRACT Recent advancements in naturally derived bioadhesives have transformed their application across diverse medical fields, including tissue engineering, wound management, and surgery. This review focuses on the innovative development multifunctional nature of these bioadhesives, particularly emphasizing role enhancing adhesion performance wet environments optimizing mechanical properties for use dynamic tissues. Key areas covered include chemical physical mechanisms adhesion, incorporation multi‐adhesion strategies that combine covalent non‐covalent bonding, bioinspired designs mimicking natural adhesives such as those barnacles mussels. Additionally, discusses emerging applications regeneration musculoskeletal, cardiac, neural, ocular tissues, highlighting potential bioadhesive‐based therapies complex biological settings. Despite substantial progress, challenges scaling lab‐based innovations clinical overcoming environmental constraints remain critical. Ongoing research bioadhesive technologies aims to bridge gaps, promising significant improvements tailored therapeutic needs.

Language: Английский

---