Dendritic donor engineering to optimize second near-infrared photothermal agents for in situ photothermal therapy

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 689, P. 137190 - 137190

Published: March 7, 2025

Language: Английский

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Pyrrolopyrrole Cyanine-Based Polymer with Superior Multifunctionality for Boosting Cancer Phototheranostics

ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1431 - 1439

Published: March 19, 2025

Molecular agents with exceptional multifunctionality are highly sought for phototheranostic applications. Herein we present a high-performance polymer near-infrared II (NIR-II) fluorescence and photoacoustic (PA) imaging-guided mild photothermal therapy (mPTT) of tumors. We synthesize series semiconducting polymers based on pyrrolopyrrole cyanine, identifying that P(P-T) exhibits large mass extinction coefficient (139 L g–1 cm–1), excellent performance, bright NIR-II fluorescence, PA imaging signals, making it among the highest-performing in these properties. A tumor-targeting agent was developed by coencapsulating heat shock protein (HSP) inhibitor camouflaging M1 macrophage membranes. The integration enables comprehensive tumor site delineation, guiding subsequent therapeutic intervention. In 4T1 tumor-bearing mice, synergistic effect mPTT under low-power 808 nm laser irradiation, combined HSP inhibition, resulted significant suppression. This work offers valuable insights designing advanced agents.

Language: Английский

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Photothermally-enhanced ferroptotic-chemo therapy enabled by ZIF-derived multizyme

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 683, P. 398 - 407

Published: Dec. 14, 2024

Language: Английский

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Stimuli-responsive hydrogel microspheres encapsulated with tumor-cell-derived microparticles for malignant ascites treatment

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 192, P. 328 - 339

Published: Nov. 24, 2024

Language: Английский

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