Inducers of Autophagy and Cell Death: Focus on Copper Metabolism

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 290, P. 117725 - 117725

Published: Jan. 1, 2025

Language: Английский

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Single-atom–doped piezocatalyst induces copper-free cuproptosis in tumor therapy

Science Advances, Journal Year: 2025, Volume and Issue: 11(7)

Published: Feb. 14, 2025

Cuproptosis, a distinct cell death pathway, has been integrated into nanomedicine for disease theranostics. However, current nanosystems inducing cuproptosis rely on exogenous toxic copper ions, limiting the scope of biomaterials. Developing nanoplatforms that induce without holds substantial promise. Here, we engineered two-dimensional iron (Fe) single-atom–doped molybdenum disulfide (MoS 2 ) piezocatalyst (Fe-MoS tumor therapy. Incorporating single Fe atoms enhances MoS piezoelectric polarization via charge redistribution and modulates Mo oxidation states, enabling multifaceted enzymatic activities, including peroxidase-, glutathione oxidase–, oxidase-, catalase-like activities. Upon ultrasound stimulation, Fe-MoS nanocatalyst generates reactive oxygen species depletes synergistic piezocatalytic enzyocatalytic effects, disrupting ion homeostasis cuproptosis, concurrently triggering ferroptosis ferritinophagy, which collectively suppression. This study represents first paradigm to introduce copper-free initiating substantially advancing applications in

Language: Английский

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Intracellular metal ion-based chemistry for programmed cell death

Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Intracellular metal ions play essential roles in multiple physiological processes, including catalytic action, diverse cellular intracellular signaling, and electron transfer. It is crucial to maintain ion homeostasis which achieved by the subtle balance of storage release intracellularly along with influx efflux at interface cell membrane. Dysregulation has been identified as a key mechanism triggering programmed death (PCD). Despite importance initiating PCD, molecular mechanisms within these processes are infrequently discussed. An in-depth understanding review role PCD may better uncover novel tools for cancer diagnosis therapy. Specifically, calcium (Ca

Language: Английский

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Nanoenhanced‐Cuproptosis Results From the Synergy of Calcium Overload and GSH Depletion with the Increasing of Intracellular Ca/Mn/Cu Ions

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Abstract Cuproptosis is a newly discovered copper‐dependent form of cell death. Intracellular glutathione (GSH) acts as copper chelator to inhibit cuproptosis, so the reduction GSH concentration conducive enhancing cuproptosis cells. In order reduce content and interfere with mitochondrial metabolism, strategy based on calcium overload depletion enhance proposed in this study. Containing manganese (Mn) (Cu) elements, CaCO 3 nanoparticles (NPs) are modified MCF‐7 aptamer (CaCO /Mn/Cu@lip‐Apt). When entering cell, /Mn/Cu@lip‐Apt decomposed released Mn* (Mn 2+ /Mn 3+ 4+ ), Cu Ca . The high valence Mn ion can effectively consume produce which catalyzed H 2 O reactive oxygen species (ROS), while reducing concentration. production ROS promoted influx exogenous large accumulation led intracellular overload, resulting dysfunction metabolism disorders. , turn triggered cuproptosis. This showed excellent antitumor effects provided new way study disease treatment.

Language: Английский

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Disrupt Mitochondrial Proton Gradients via Flexoelectric Catalysis to Deplete Tumor Energy and Enhance Immunotherapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Abstract Mitochondria, recognized as the cellular powerhouse, provide a continuous stream of energy essential for rapid proliferation and elevated metabolic demands tumor cells. Herein, flexoelectric nanocatalyst, SrTiO₃/RGD/TPP (SRT), is engineered to disrupt mitochondrial proton gradients ionic balance through ultrasound‐induced catalysis. This interference impedes production, resulting in cell apoptosis due an inadequate supply. Upon ultrasound stimulation, SRT experiences polarization stress gradient, separation positive negative charges, thereby generating local electric field. The charges interact with protons (H⁺) intermembrane space produce hydrogen (H₂), reducing concentration disrupting subsequently inhibiting ATP synthesis. Concurrently, field modifies membrane potential (MMP), opening calcium uniporter (MCU) channels facilitating influx ions, overload dysfunction, ultimately severing supply disruption energy, when combined immunotherapy, demonstrates significant inhibition both vitro vivo models. Through integration catalysis this study potent anti‐tumor effects proposes new research directions nanomedicine.

Language: Английский

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Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Abstract Targeted regulation of pyroptosis to modulate the immune landscape has emerged as a novel design strategy for cancer immunotherapy and anti‐inflammatory therapy. However, acts double‐edged sword, making it important optimize strategies functional materials appropriately activate effective disease treatment. This paper summarizes discusses structure, pore formation, molecular mechanisms “executor” Gasdermins, well events preceding following these processes. Subsequently, focus is on reviewing that directly regulate Gasdermin formation target those indirectly before after control activity. Finally, advantages, disadvantages, future prospects designing such are provided, aiming facilitate precise design, pharmacological investigation, clinical translation pyroptosis‐related materials.

Language: Английский

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A Copper‐Based Photothermal‐Responsive Nanoplatform Reprograms Tumor Immunogenicity via Self‐Amplified Cuproptosis for Synergistic Cancer Therapy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Studies show that intracellular accumulation of copper ions causes cuproptosis, potentially enhancing anticancer immunity. However, the induction cuproptosis inevitably faces challenges due to low deliver efficiency and collateral damage normal tissues. This paper presents a self-amplified nanoplatform (CEL NP) composed Cu2- XS hollow nanospheres (HNSs), elesclomol (ES), phase-change material lauric acid (LA). Under NIR-II laser irradiation, photothermal energy generated by HNSs melts LA, facilitating precise release ES within tumor microenvironment. Notably, can traverse cell membrane form ES-Cu(II) complexes, thereby delivery cells. Excess Cu(II) also reacts with endogenous glutathione, reducing its inhibitory effect on cuproptosis. Ultimately, this amplified activate immunogenic death, eliciting robust immune response promoting suppression. The CEL NP-mediated offers novel approach for therapy through induction.

Language: Английский

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Tumor-targeting Nanomaterials Based on Metal-organic Frameworks Mediate Tumor Immunotherapy by Promoting Cuproptosis and Pyroptosis in Hepatocellular Carcinoma Cells

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101745 - 101745

Published: April 1, 2025

Language: Английский

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Multi-pathway copper metabolisms regulation based on an engineered copper/ferrous nanoplatform for enhanced tumor cuproptosis therapy

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114682 - 114682

Published: April 1, 2025

Language: Английский

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Shining a light on pyroptosis in cancer chemotherapy by multi-modal imaging with a dual-channel nanoreporter

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163018 - 163018

Published: April 1, 2025

Language: Английский

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