Interfering with proton and electron transfer enables antibacterial starvation therapy DOI Creative Commons
Ji Tan, Haifeng Zhang, Yisi Liu

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(12)

Published: March 19, 2025

Implant-associated infections are urgently addressed; however, existing materials difficult to kill bacteria without damaging cells. Here, we propose an innovative concept of selective antibacterial starvation therapy based on interfering with proton and electron transfer the bacterial membrane. As a proof-of-principle demonstration, special Schottky heterojunction film composed gold alkaline magnesium-iron mixed metal oxides (Au/MgFe-MMO) was constructed titanium implant. Once contacted this implant, Au/MgFe-MMO continuously captured participated in respiratory chain impede their energy metabolism, leading deficit adenosine 5′-triphosphate. Prolonged exposure state inhibited numerous biosynthesis processes triggered severe oxidative stress bacteria, ultimately death due DNA membrane damage. In addition, comfortable for mammalian cells, inhibiting mitochondrial function. This proposed gives notable perspective designing biosafe smart biomaterials.

Language: Английский

Temperature‐Resilient Polymeric Memristors for Effective Deblurring in Static and Dynamic Imaging DOI Creative Commons
Ziyu Lv,

Minghao Jiang,

Huiying Liu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Abstract Organic memristors have emerged as promising candidates for neuromorphic computing due to their potential low‐cost fabrication, large‐scale integration, and biomimetic functionality. However, practical applications are often hindered by limited thermal stability device‐to‐device variability. Here, an organic polymer‐based memristor using a thiadiazolobenzotriazole (TBZ) 2,5‐Dioctyl‐3,6‐di(thiophen‐2‐yl)pyrrolo[3,4‐c]pyrrole‐1,4(2H,5H)‐dione (DPP)‐based conjugated polymer is presented that exhibits exceptional reliable resistance switching behavior over wide temperature range (153–573 K). The device leverages charge‐transfer mechanism achieve gradual uniform switching, overcoming the challenges associated with filamentary‐based mechanisms. memristor's consistent performance enable its integration into various applications, including image processing. device's ability demonstrated effectively deblur images, even under varying conditions, showcasing robust computing. This study establishes pathway toward high‐performance, thermally stable advanced artificial intelligence applications.

Language: Английский

Citations

1
Interfering with proton and electron transfer enables antibacterial starvation therapy DOI Creative Commons
Ji Tan, Haifeng Zhang, Yisi Liu

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(12)

Published: March 19, 2025

Implant-associated infections are urgently addressed; however, existing materials difficult to kill bacteria without damaging cells. Here, we propose an innovative concept of selective antibacterial starvation therapy based on interfering with proton and electron transfer the bacterial membrane. As a proof-of-principle demonstration, special Schottky heterojunction film composed gold alkaline magnesium-iron mixed metal oxides (Au/MgFe-MMO) was constructed titanium implant. Once contacted this implant, Au/MgFe-MMO continuously captured participated in respiratory chain impede their energy metabolism, leading deficit adenosine 5′-triphosphate. Prolonged exposure state inhibited numerous biosynthesis processes triggered severe oxidative stress bacteria, ultimately death due DNA membrane damage. In addition, comfortable for mammalian cells, inhibiting mitochondrial function. This proposed gives notable perspective designing biosafe smart biomaterials.

Language: Английский

Citations

0