Autonomous, Moisture‐Driven Flexible Electrogenerative Dressing for Enhanced Wound Healing

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Abstract Electrotherapy has shown considerable potential in treating chronic wounds, but conventional approaches relying on bulky external power supplies and mechanical force are limited their clinical utility. This study introduces an autonomous, moisture‐driven flexible electrogenerative dressing (AMFED) that overcomes these limitations. The AMFED integrates a moist‐electric generator (MEG), antibacterial hydrogel dressing, concentric molybdenum (Mo) electrodes to provide self‐sustaining electrical supply potent activity against Staphylococcus aureus Escherichia coli . MEG harnesses chemical energy from moisture produce stable direct current of 0.61 V without input, delivering this therapeutic stimulation the wound site through Mo electrodes. facilitates macrophage polarization toward reparative M2 phenotype regulates inflammatory cytokines. Moreover, vivo studies suggest group significantly enhances healing, with approximate 41% acceleration compared control group. Using diabetic mouse model, demonstrates its effectiveness promoting nerve regulation, epithelial migration, vasculogenesis. These findings present novel efficient platform for accelerating healing.

Language: Английский

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Bioinspired Intelligent Electronic Skin for Medicine and Healthcare

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Intelligent electronic skin aims to mimic, enhance, and even surpass the functions of biological skin, enabling artificial systems sense environmental stimuli interact more naturally with humans. In healthcare, intelligent is revolutionizing diagnostics personalized medicine by detecting early signs diseases programming exogenous for timely intervention on‐demand treatment. This review discusses latest progress in bioinspired its application healthcare. First, strategies development simulate or human are discussed, focusing on basic characteristics, as well sensing regulating functions. Then, applications health monitoring wearable therapies illustrating potential provide warning Finally, significance bridging gap between emphasized challenges future perspectives summarized.

Language: Английский

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Stimuli‐responsive magnesium‐based materials for biomedical applications: A review

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

Abstract As one of the revolutionizing biodegradable metals, Magnesium (Mg) has gained global attention from researchers due to positive clinical feedback in bone fixation and cardiovascular repair. In many cases, attributed its biological effects degradation products Mg, overlooking interactions between Mg microenvironment within bodies, as well additional physical/chemical reactions induced by endogenous exogenous stimuli on tissues. recent years, academic community increasingly focused responsiveness Mg‐based materials for tissue repair disease treatment. However, there is a lack systematic summaries “composition‐structure‐function” relationships when are applied various physiological scenarios. To address this gap, review summarizes under over past decade. Endogenous mainly include changes spontaneously released 2 ⁺ ions concentration, pH variations, body fluid infiltration, reactive oxygen species intervention, temperature changes, enzyme involvement. Exogenous primarily involve external fields such photo‐irradiation, electric field, magnetic ultrasound, mechanical stress. By activating these endogenous/exogenous stimuli, specific functions can be triggered needed, leading more pronounced therapeutic compared non‐stimulated state. Accordingly, we also analyze mechanisms underlying enhanced impact. Based existing research, further examines limitations studies different stimulation scenarios proposes suggestions future research improvements. Ultimately, hope could provide new insights efficient application future.

Language: Английский

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Interfering with proton and electron transfer enables antibacterial starvation therapy

Science Advances, Journal Year: 2025, Volume and Issue: 11(12)

Published: March 19, 2025

Implant-associated infections are urgently addressed; however, existing materials difficult to kill bacteria without damaging cells. Here, we propose an innovative concept of selective antibacterial starvation therapy based on interfering with proton and electron transfer the bacterial membrane. As a proof-of-principle demonstration, special Schottky heterojunction film composed gold alkaline magnesium-iron mixed metal oxides (Au/MgFe-MMO) was constructed titanium implant. Once contacted this implant, Au/MgFe-MMO continuously captured participated in respiratory chain impede their energy metabolism, leading deficit adenosine 5′-triphosphate. Prolonged exposure state inhibited numerous biosynthesis processes triggered severe oxidative stress bacteria, ultimately death due DNA membrane damage. In addition, comfortable for mammalian cells, inhibiting mitochondrial function. This proposed gives notable perspective designing biosafe smart biomaterials.

Language: Английский

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Sound Wave‐Activated Self‐Powered Adhesive Dressing for Accelerated Wound Healing

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Abstract Self‐powered wound dressings are effective in treating chronic wounds because of their low toxicity and convenience. However, current self‐powered rely on the bending movements skin or additional large ultrasonic devices. Herein, a flexible adhesive dressing (FASW) that promotes regeneration through daily sound wave driving without relying external devices is proposed. The FASW consists bioadhesive film (BAF), unidirectional fluorinated conductive (UFCF), liquid metal (LM) interlayer. Benefiting from cross‐linking chitosan, exhibits excellent properties, such as biocompatibility, stretchability, tissue adhesion, recyclability. In vivo experiments show reduced inflammation stimulated hair follicle regeneration. This utilizes previously overlooked natural energies for treatment wounds, thereby enhancing therapeutic effect traditional individuals with movement disorders.

Language: Английский

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Electro‐ and Magneto‐Active Biomaterials for Diabetic Tissue Repair: Advantages and Applications

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Abstract The diabetic tissue repair process is frequently hindered by persistent inflammation, infection risks, and a compromised microenvironment, which lead to delayed wound healing significantly impact the quality of life for patients. Electromagnetic biomaterials offer promising solution enabling intelligent detection wounds through electric magnetic effects, while simultaneously improving pathological microenvironment reducing oxidative stress, modulating immune responses, exhibiting antibacterial action. Additionally, these materials inherently promote regeneration regulating cellular behavior facilitating vascular neural repair. Compared traditional biomaterials, electromagnetic provide advantages such as noninvasiveness, deep penetration, responsiveness, multi‐stimuli synergy, demonstrating significant potential overcome challenges This review comprehensively examines superiority in repair, elucidates underlying biological mechanisms, discusses specific design strategies applications tailored characteristics wounds, with focus on skin bone defect By addressing current limitations pursuing multi‐faceted strategies, hold improve clinical outcomes enhance

Language: Английский

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Structural Design of Biodegradable Mg Gastrointestinal Anastomosis Staples for Corrosion and Mechanical Strength Analysis

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Magnesium (Mg) and its alloys, as next-generation materials for anastomosis staples, offer promising advantages such biodegradability, biocompatibility, reduced risk of long-term complications compared to traditional titanium materials. However, the performance biodegradable staples is highly dependent on their structure. In this study, a high-purity (HP) Mg staple with an optimized structure intended small intestine was developed evaluated in vitro. The designed staple, diameter 0.3 mm, featured interior angle 100° height 3.8 mm. This design exhibited maximum effective stress approximately 170 MPa strain 1.63. could maintain structural integrity without fracture after 7 days vitro corrosion testing relatively high burst pressure 54.70 ± 2.51 mmHg. These findings indicate that newly HP combines superior resistance strength, confirming potential clinical application.

Language: Английский

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Self-Powered Thermoelectric Hydrogels Accelerate Wound Healing

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Electrical stimulation (ES) serves as a biological cue that regulates critical cellular processes, including proliferation and migration, offering an effective approach to accelerating wound healing. Thermoelectrics, capable of generating electricity by exploiting the temperature difference between skin surrounding environment without external energy input, present promising avenue for ES-based therapies. Herein, we developed Ag2Se@gelatin methacrylate (Ag2Se@GelMA) thermoelectric hydrogels with high room-temperature performance employed them self-powered ES devices repair. Systematic in vivo vitro investigations elucidated their mechanisms enhancing Our findings reveal Ag2Se@GelMA can significantly accelerate closure amplifying endogenous electric field, thereby promoting cell proliferation, angiogenesis. Comprehensive experiments demonstrated generated activates voltage-gated calcium ion channels, elevating intracellular Ca2+ levels mitochondrial functions through Ca2+/CaMKKβ/AMPK/Nrf2 pathway. This cascade improves dynamics angiogenesis, tissue regeneration. The newly represent marked progress dressing technology potential improve clinical strategies engineering regenerative medicine.

Language: Английский

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Advanced implantable energy storage for powering medical devices

eScience, Journal Year: 2025, Volume and Issue: unknown, P. 100409 - 100409

Published: April 1, 2025

Language: Английский

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An Implantable In‐Hydrogel Wireless Supercapacitor‐Activated Neuron System Enables Bidirectional Modulation

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Abstract The bidirectional modulation of cerebral neurons in the brain possesses enhancement and inhibition neural activity, which is great interest treatment motor nerve disorders emotional disorders, cognitive defects. However, existing approaches usually rely on electrical/electrochemical stimulations, show low security by implanting metal probes unidirectional currents with single modulation. Herein, an implantable in‐hydrogel wireless supercapacitor‐activated neuron system consisting coil, diode bridge circuit, supercapacitor, stimulation electrodes fabricated, provides a adjustable ion diffusion current to safely effectively excite inhibit neurons. designed supercapacitor exhibits high storage charge ability ≈90 times larger than devices without hydrogel encapsulation, owing situ radical addition mechanism. Moreover, are implanted into thalamus, amygdala, prefrontal lobes evoke corresponding changes potential intensity frequency through external chargeable coil verifies multimodule amelioration Parkinson's, severe depression, Alzheimer's disease.

Language: Английский

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