Optical Bionanosensors for Sepsis Diagnostics
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 2, 2025
Sepsis
is
a
global
health
challenge,
characterized
by
dysregulated
immune
response,
leading
to
organ
dysfunction
and
death.
Despite
advances
in
medical
care,
sepsis
continues
claim
significant
toll
on
human
lives,
with
mortality
rates
from
10-25%
for
30-50%
septic
shock,
making
it
cause
of
death
worldwide.
Current
diagnostic
methods
rely
clinical
signs,
laboratory
parameters,
or
microbial
cultures
suffer
delays
inaccuracies.
Therefore,
there
pressing
need
novel
tools
that
can
rapidly
accurately
identify
sepsis.
This
review
highlights
biosensor
development
could
ultimately
lead
faster
more
accurate
diagnostics.
The
focus
nanomaterial-based
optical
approaches
promise
rapid
diagnostics
without
the
large
equipment
trained
personnel.
An
overview
provided,
highlighting
potential
molecular
targets
challenges
they
present
assay
development.
requirements
an
ideal
point-of-care
test
(POC)
are
discussed,
including
speed,
simplicity,
cost-effectiveness.
Different
nanomaterials
suitable
various
detection
reviewed
innovative
nanosensors
discussed
diagnostics,
focusing
chemical
design
increase
selectivity
multiplexing.
Language: Английский
Comparison of Microfluidic Synthesis of Silver Nanoparticles in Flow and Drop Reactors at Low Dean Numbers
Micromachines,
Journal Year:
2025,
Volume and Issue:
16(1), P. 75 - 75
Published: Jan. 10, 2025
This
study
evaluates
the
performance
of
continuous
flow
and
drop-based
microfluidic
devices
for
synthesis
silver
nanoparticles
(AgNPs)
under
identical
hydrodynamic
chemical
conditions.
Flows
at
low
values
Dean
number
(De
<
1)
were
investigated,
where
contribution
vortices
forming
inside
drop
to
additional
mixing
reactor
should
be
most
noticeable.
In
device,
discrete
aqueous
drops
serving
as
reactors
generated
by
focusing
using
silicone
oil
phase.
Aqueous
solutions
reagents
supplied
through
two
different
channels
merging
just
before
formed.
merged
a
Tee
junction,
reaction
was
carried
out
in
outlet
tube.
Although
systems
may
face
challenges
such
particle
concentration
reduction
due
deposition
on
channel
wall
or
fouling,
they
are
often
more
practical
research
their
operational
simplicity,
primarily
elimination
need
separate
nanoparticle
dispersion
from
The
results
demonstrate
that
both
approaches
produced
AgNPs
similar
sizes
when
conditions
defined
De
residence
time
within
similar.
Language: Английский
Photophysical Properties of Tandem Quantum Defects in Carbon Nanotubes
The Journal of Physical Chemistry Letters,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1573 - 1581
Published: Feb. 4, 2025
Single-walled
carbon
nanotubes
(SWCNTs)
are
versatile
near-infrared
(NIR)
fluorophores
that
can
be
chemically
functionalized
to
create
biosensors.
Numerous
noncovalent
approaches
were
developed
detect
analytes,
but
these
design
concepts
susceptible
nonspecific
binding
and
reduced
stability.
In
contrast,
covalent
modification
of
SWCNTs
with
quantum
defects
utilized
tune
their
fluorescence
properties
enable
new
molecular
recognition
concepts.
Here,
we
present
assess
four
different
synthetic
pathways/sequences
modify
covalently
both
sp3
DNA-based
guanine
defects.
We
find
it
is
possible
two
defect
types
without
disrupting
the
optical
or
chemical
Interestingly,
emission
peak
associated
(E11*)
shifts
around
3
nm
when
combined
defects,
indicating
a
coupling
between
types.
However,
far
lower
than
red-shift
in
bandgap-related
(E11)
by
(40
nm).
furthermore
demonstrate
combinations
used
for
(bio)sensing.
summary,
combination
multiple
provides
platform
multifunctional
biosensors
space
explored.
Language: Английский
Near‐Infrared Fluorescent Single‐Walled Carbon Nanotubes for Biosensing
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 2, 2025
Abstract
The
objective
of
this
article
is
to
provide
a
comprehensive
overview
the
recent
advancements
in
biosensing
using
near‐infrared
(NIR)
fluorescent
single‐walled
carbon
nanotubes
(SWCNTs).
SWCNTs
are
cylindrical
structures
formed
by
rolling
up
graphene
layer,
with
their
chiral
index
(n,m)
defining
diameter
and
electronic,
mechanical,
optical
properties,
making
them
metallic,
semimetallic,
or
semiconducting.
semiconducting
variants
feature
NIR
fluorescence,
which
offers
significant
advantages
for
biological
imaging
sensing
due
deep
tissue
penetration
minimal
background
interference.
Moreover,
highly
photostable,
demonstrating
resistance
photobleaching
blinking.
Owing
these
unique
have
been
widely
used
as
probes
monitoring
broad
spectrum
analytes,
ranging
from
small
molecules
macromolecules.
This
review
explores
photophysics
SWCNTs,
suitability
biosensing,
strategies
developing
effective
SWCNT‐based
sensors.
begins
photophysical
highlighting
relevance
followed
key
technical
concepts.
Additionally,
principles,
methods
optimizing
functionalized
diverse
approaches
also
covered.
Overall,
intends
foundational
understanding
equipping
readers
knowledge
needed
explore
apply
powerful
nanomaterials
applications.
Language: Английский