Gold-Cerium bimetallic Star-Shaped nanoplatform for synergistic tumor therapy with nanozyme Catalytic/Photothermal/Chemotherapy

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 685, P. 753 - 765

Published: Jan. 20, 2025

Language: Английский

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Octa-Cationic Porphyrin-Functionalized Biocompatible Nanocomposite: A Promising Candidate for Enhanced Combinatorial Photodynamic and Photothermal Tumor Therapy

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

The integration of photodynamic therapy (PDT) and photothermal (PTT) offers a promising strategy for enhancing phototherapy efficiency. Herein, we present dual-functional, biocompatible nanocomposite system combination PDT/PTT therapy. utilizes highly nanoparticle assembled by an amphiphilic short peptide with the assistance Zn2+ as carrier. convertor is loaded within nanoparticle, while cationic porphyrin photosensitizer on surface. water-soluble (M8PzEOPP), designed eight positive charges, provides strong electrostatic interaction stable assembly This location-independent effectively maintains optical characteristics both convertor, endowing effective properties. exhibits excellent tumor-targeting accumulation behavior, low dark toxicity, robust extracellular biostability, high cell internalization Its enhanced performance in combinatorial demonstrated through vitro vivo experiments.

Language: Английский

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Photonic Nanomaterials for Wearable Health Solutions

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract This review underscores the transformative potential of photonic nanomaterials in wearable health technologies, driven by increasing demands for personalized monitoring. Their unique optical and physical properties enable rapid, precise, sensitive real‐time monitoring, outperforming conventional electrical‐based sensors. Integrated into ultra‐thin, flexible, stretchable formats, these materials enhance compatibility with human body, enabling prolonged wear, improved efficiency, reduced power consumption. A comprehensive exploration is provided integration devices, addressing material selection, light‐matter interaction principles, device assembly strategies. The highlights critical elements such as form factors, sensing modalities, data communication, representative examples skin patches contact lenses. These devices precise monitoring management biomarkers diseases or biological responses. Furthermore, advancements approaches have paved way continuum care systems combining multifunctional sensors therapeutic drug delivery mechanisms. To overcome existing barriers, this outlines strategies design, engineering, system integration, machine learning to inspire innovation accelerate adoption next‐generation health, showcasing their versatility digital applications.

Language: Английский

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Silk Nonwoven Fabric‐Based Dressing with Antibacterial and ROS‐Scavenging Properties for Modulating Wound Microenvironment and Promoting Diabetic Wound Healing

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

The microenvironment of diabetic wounds is exceptionally complex, characterized notably by persistent bacterial infections and the excessive production reactive oxygen species (ROS). Traditional treatment methods often fall short achieving ideal results. Consequently, there an urgent need to develop implement more advanced efficient strategies effectively address complexity recalcitrance wounds. This study pioneers a novel approach fabricating silk fibroin-based nonwoven dressing (SF-Ag-HCA) under neutral conditions, integrating silver ions with dihydrocaffeic acid-modified fibroin. Uniquely, this achieves dual functionality: exceptional antibacterial efficacy against common pathogens (E. coli, S. aureus, P. aeruginosa) robust ROS-scavenging capabilities, mitigating oxidative stress promoting immune homeostasis. SF-Ag-HCA not only surpasses conventional materials in regulating wound but also accelerates re-epithelialization collagen deposition. Animal studies further validate its superior performance healing infected compared commercial alternatives. innovative represents significant advancement care, offering integrated, cost-effective solution tailored for complex chronic management.

Language: Английский

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ZnFe Layered Double Hydroxide Nanosheets Loaded with Cu Single‐Atom Nanozymes with Multi‐Enzyme‐Like Catalytic Activities as an Effective Treatment for Bacterial Keratitis

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Bacterial keratitis (BK) is a type of corneal inflammation resulting from bacterial infection in the eye. Although nanozymes have been explored as promising materials wound healing, currently available lack sufficient catalytic activity and ability to penetrate biofilms, limiting their efficacy against treatment BK. To remedy this, ZnFe layered double hydroxide (ZnFe‐LDH) nanosheets are loaded with Cu single‐atom (Cu‐SAzymes) aminated dextran (Dex‐NH 2 ), formation nanozyme DT‐ZnFe‐LDH@Cu, which possesses peroxidase (POD)‐, oxidase (OXD)‐, catalase (CAT)‐like activities. This enables generate reactive oxygen species (ROS), such hydroxyl radicals ( • OH), superoxide anion radical (O •− singlet 1 O ) hydrogen peroxide (H thereby killing bacteria causing infections. The surface Dex‐NH enabled DT‐ZnFe‐LDH@Cu biofilm adsorb onto extracellular polymeric substances (EPS) produced by biofilm. Additionally, successfully repaired P. aeruginosa ‐infected injury BK rabbit model more effectively than commercially tobramycin eye drops. was enabled, part, reduce promoting polarization pro‐inflammatory macrophages (M1) anti‐inflammatory (M2) decrease expression α‐smooth muscle actin (α‐SMA) promote healing without scar formation. study provides an innovative concept for holds great scientific value clinical application potential.

Language: Английский

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3D printing of multifunctional hydrogel scaffolds based on recombinant collagen for bile duct repair

APL Materials, Journal Year: 2025, Volume and Issue: 13(2)

Published: Feb. 1, 2025

Bile duct injuries remain a significant clinical challenge following hepatobiliary surgeries. Recently, 3D-printed tubular scaffolds have shown promise as effective solutions for bile tissue repair. This study presents novel bi-layered scaffold, fabricated using advanced three-dimensional printing technology. The inner layer of this scaffold is constructed from poly(ε-caprolactone) methacrylate (PCLMA), which imparts high mechanical strength. outer composed biocompatible methacrylated recombinant type I collagen (rColMA) and ε-poly(L-lysine)-methacrylamide (EPLMA), providing excellent antibacterial properties. In addition, encapsulated interleukin-6-loaded liposomes (IL-6@Lip) are incorporated into the to further promote regeneration. innovative design creates an optimal microenvironment growth differentiation bone marrow mesenchymal stem cells (BMSCs) duct-like cells. These differentiated contribute regeneration, evidenced by expression key markers, including CK7, CK19, AQP1, AE2, CX43. rColMA/EPLMA/IL-6@Lip hydrogel in significantly enhances BMSC proliferation their epithelial Furthermore, vivo experiments show that PCLMA//rColMA/EPLMA/IL-6@Lip does not induce stasis. novel, pre-differentiated active offers valuable insights regeneration replacement research.

Language: Английский

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H₂S/Curcumin Coreleasing Biomineralized Zinc Sulfide Nanostructures for Diabetic Wound Healing

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

Language: Английский

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Recent advances and challenges in metal-based antimicrobial materials: a review of strategies to combat antibiotic resistance

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 9, 2025

Despite the availability of a series classical antibiotic drugs, bacterial infections continue to represent significant and urgent threat global human health. The emergence drug-resistant bacteria slow pace development have rendered current treatment methods inadequate in meeting clinical demands infections. Consequently, there is an increasingly vital need for safe, efficient, alternative novel antimicrobial agents medical healthcare field. Over past five years, has been notable expansion field nanomedicine with regard prevention control infectious diseases. objective this article provide comprehensive review latest research developments metal nanomaterials therapy. We begin by delineating gravity infection crisis, subsequently undertaking examination potential mechanisms through which nanoparticles may combat specific applications these diverse In conclusion, we eagerly anticipate future directions believe that continuous technological advancements innovations, will make even more outstanding contributions safeguarding health well-being.

Language: Английский

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Biosilicification-mimicking chiral nanostructures for targeted treatment of inflammatory bowel disease

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 15, 2025

The cascade reaction of lipopolysaccharides (LPS), cell-free DNA (cfDNA), and reactive oxygen species (ROS), drives the development inflammatory bowel disease (IBD). Herein, we construct polyethylenimide (PEI)-L/D-tartaric acid (L/D-TA) complexes templated mesoporous organosilica nanoparticles (MON) (PEI-L/D-TA@MON) by mimicking biosilicification under ambient conditions within seconds. chiral nanomedicines include four functional moieties, wherein PEI electrostatically attracts cfDNA, tetrathulfide bonds reductively react with ROS, silanol groups adsorb LPS, L/D-TA enables recognition localization. Following oral administration, PEI-L-TA@MON exhibiting preferential conformation stereoscopically matches mucosa anchors onto intestine for lesion targeting. eliminates alleviating oxidative stress, inhibiting cascade, maintaining immune homeostasis to achieve IBD therapy. In addition, rapid synthesis, low cost, energy-free preparation, negligible toxicity, satisfactory therapeutic effect, facile conversion on modes will bring changes treatment, providing research values translational clinical prospects. Here, Xu et. al. composed moieties eliminate cfDNA targeted treatment IBD.

Language: Английский

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Artificial multienzyme nanoflower composite hydrogel for efficiently promoting MRSA-infected diabetic wound healing via glucose-activated NO releasing and microenvironment regulation

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 531 - 548

Published: March 22, 2025

Language: Английский

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