Mitochondrial-Targeted Multifunctional Platinum-Based Nano “Terminal-Sensitive Projectile” for Enhanced Cancer Chemotherapy Efficacy DOI
Qiang Zhang, Jiamin Lin,

Jun Li

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Platinum-based anticancer drugs exert their effects by forming adducts within nuclear DNA (nDNA), inhibiting transcription and inducing apoptosis in cancer cells. However, tumor cells have evolved mechanisms to resist these drugs. Given mitochondria's role lack of nucleotide excision repair (NER), targeting mitochondrial (mtDNA) offers a strategy. Herein, platinum-based terminal-sensitive projectile (TSB) which comprises heterofunctional tetravalent platinum prodrug as the primary warhead, complemented guidance system incorporating triphenylphosphine (TPP) secondary FFa (Fenofibric acid) was developed. TSB then encapsulated IR780 coupling DSPE-PEG2K for enhanced delivery (NTSB). This design allows be precisely targeted into intertumoral mitochondria its terminal, releasing free oxaliplatin (OXA) upon reaching terminal destination. The accumulation OXA leads cross-linking with mtDNA, causing dysfunction, while disrupts electron transport chain (ETC), impairing oxidative phosphorylation (OXPHOS). Furthermore, under near-infrared (NIR) irradiation, component generates phototherapeutic thermal effect reactive oxygen species (ROS), deplete intracellular glutathione (GSH) levels facilitate Pt mtDNA. Both vitro vivo studies demonstrated that this comprehensive approach significantly enhances sensitivity chemotherapeutic

Language: Английский

A hyaluronic acid modified advanced nanoagent activated by tumor microenvironment enables a reciprocal dual-modality therapy DOI
Jiaxuan Li,

Zelong Chen,

Zhichao Pei

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159884 - 159884

Published: Feb. 1, 2025

Language: Английский

Citations

1
Plasmonic Nanodiamond – Microneedle Bioinspired System for Ultrarapid Sampling and Quantum Sensing of Melanoma‐Related MiRNA DOI Open Access
Min Wu, Lei Liu,

Youqiang Xing

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Abstract MicroRNA (miRNA) in interstitial fluid (ISF) is a promising biomarker for early disease diagnosis, but its quantification challenging due to low sampling efficiency and weak signals. Here, inspired by the osmotic pressure‐driven feeding mechanism of sea anemones, novel designed that plasmonic nanodiamonds – microneedles (PND‐MNs) bioinspired system ultrarapid quantum sensing melanoma‐related miRNA. Specifically, high‐osmotic hydrogel microneedles, prepared immersing LiCl solution, exhibit substantial swelling ratio rapid ISF enrichment, extracting 0.92 ± 0.14 mg within 5 min. Concurrently, coating fluorescent (FNDs) with hollow composite metal Au‐Ag NPs, precise modulation fluorescence intensity nitrogen vacancy color centers (NV‐center) FNDs has been achieved. This innovative technology significantly enhances signal PND‐MNs system, amplifying it factor 16, reducing detection limit miRNA an unprecedented 0.68 f m (to knowledge, no method based on detecting biomarkers surpassed this level). Furthermore, employing backpropagation neural network (BPNN), achieves high accuracy recognizing concentrations (R 2 = 0.9986). By combining sampling, enhancement, machine learning, holds promise biomarkers, offering significant clinical applications.

Language: Английский

Citations

0
Mitochondrial-Targeted Multifunctional Platinum-Based Nano “Terminal-Sensitive Projectile” for Enhanced Cancer Chemotherapy Efficacy DOI
Qiang Zhang, Jiamin Lin,

Jun Li

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Platinum-based anticancer drugs exert their effects by forming adducts within nuclear DNA (nDNA), inhibiting transcription and inducing apoptosis in cancer cells. However, tumor cells have evolved mechanisms to resist these drugs. Given mitochondria's role lack of nucleotide excision repair (NER), targeting mitochondrial (mtDNA) offers a strategy. Herein, platinum-based terminal-sensitive projectile (TSB) which comprises heterofunctional tetravalent platinum prodrug as the primary warhead, complemented guidance system incorporating triphenylphosphine (TPP) secondary FFa (Fenofibric acid) was developed. TSB then encapsulated IR780 coupling DSPE-PEG2K for enhanced delivery (NTSB). This design allows be precisely targeted into intertumoral mitochondria its terminal, releasing free oxaliplatin (OXA) upon reaching terminal destination. The accumulation OXA leads cross-linking with mtDNA, causing dysfunction, while disrupts electron transport chain (ETC), impairing oxidative phosphorylation (OXPHOS). Furthermore, under near-infrared (NIR) irradiation, component generates phototherapeutic thermal effect reactive oxygen species (ROS), deplete intracellular glutathione (GSH) levels facilitate Pt mtDNA. Both vitro vivo studies demonstrated that this comprehensive approach significantly enhances sensitivity chemotherapeutic

Language: Английский

Citations

0