Intelligent Generic High‐Throughput Oscillatory Shear Technology Fabricates Programmable Microrobots for Real‐Time Visual Guidance During Embolization DOI
Xuqi Peng,

Haitian Tang,

Zhenwen Zhao

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Abstract Microrobots for endovascular embolization face challenges in precise delivery within dynamic blood vessels. Here, an intelligent generic high‐throughput oscillatory shear technology (iGHOST) is proposed to fabricate diversely programmable, multifunctional microrobots capable of real‐time visual guidance vivo embolization. Leveraging machine learning (ML), key synthesis parameters affecting the success and sphericity are identified. Therefore, ML‐optimized iGHOST enables continuous production uniform with programmable sizes (400−1000 µm) at ultrahigh rate exceeding 240 mL h −1 by segmenting fluid into droplets before ionic cross‐linking, without requiring purification. Particularly, iGHOST‐fabricated magnetically responsive lipiodol‐calcium alginate (MagLiCA) highly distinguishable under X‐ray imaging, which allows navigation flows up 4 min accurate liver kidney vessels, thus addressing current issues. Crucially, MagLiCA possess drug‐loading capabilities, enabling simultaneous site‐specific treatment. The process intelligent, rapid, green manufacturing method, can produce size‐controllable, potential drug treatment imaging across various medical applications.

Language: Английский

Magnetic Continuum Robot for Intelligent Manipulation in Medical Applications DOI Creative Commons
Yuntao Ma, Xuanyu An,

Qijun Yang

et al.

Published: April 3, 2025

ABSTRACT Magnetic continuum robots (MCRs) have garnered substantial attention as a new class of flexible robotic systems capable navigating complex and confined spaces with remarkable dexterity. By combining continuous, deformable structures remotely applied magnetic fields, MCRs achieve contactless, remote manipulation, making them well‐suited for medical applications. This review introduces recent advances in MCR research, focusing on design principles, structural configurations, control strategies. Various designs structures, including those integrated permanent magnets, matter, ferromagnetic sphere, micro coil, are discussed. Furthermore, different actuation platforms introduced, the level automation is classified based Key intelligent manipulation capabilities MCRs, navigation, delivery, printing, grasping, imaging, sensing explored. Finally, future development priorities directions identified to provide insights advancing systems.

Language: Английский

Citations

0
Intelligent Generic High‐Throughput Oscillatory Shear Technology Fabricates Programmable Microrobots for Real‐Time Visual Guidance During Embolization DOI
Xuqi Peng,

Haitian Tang,

Zhenwen Zhao

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Abstract Microrobots for endovascular embolization face challenges in precise delivery within dynamic blood vessels. Here, an intelligent generic high‐throughput oscillatory shear technology (iGHOST) is proposed to fabricate diversely programmable, multifunctional microrobots capable of real‐time visual guidance vivo embolization. Leveraging machine learning (ML), key synthesis parameters affecting the success and sphericity are identified. Therefore, ML‐optimized iGHOST enables continuous production uniform with programmable sizes (400−1000 µm) at ultrahigh rate exceeding 240 mL h −1 by segmenting fluid into droplets before ionic cross‐linking, without requiring purification. Particularly, iGHOST‐fabricated magnetically responsive lipiodol‐calcium alginate (MagLiCA) highly distinguishable under X‐ray imaging, which allows navigation flows up 4 min accurate liver kidney vessels, thus addressing current issues. Crucially, MagLiCA possess drug‐loading capabilities, enabling simultaneous site‐specific treatment. The process intelligent, rapid, green manufacturing method, can produce size‐controllable, potential drug treatment imaging across various medical applications.

Language: Английский

Citations

0