Cited by Ferroptosis mediated inhibition of breast cancer cells by β–elemene incorporated GSH/pH dual responsive nanomicelles

Biomimetic Dual‐Driven Heterojunction Nanomotors for Targeted Catalytic Immunotherapy of Glioblastoma DOI

Jiamin Ye,

Yueyue Fan,

Yong Kang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Abstract The existence of the blood–brain barrier (BBB) and characteristics immunosuppressive microenvironment in glioblastoma (GBM) present significant challenges for targeted GBM therapy. To address this, a biomimetic hybrid cell membrane‐modified dual‐driven heterojunction nanomotor (HM@MnO 2 ‐AuNR‐SiO ) is proposed treatment. These nanomotors are designed to bypass BBB target glioma regions by mimicking surface macrophage membranes. More importantly, MnO structure enables propulsion through near‐infrared‐II (NIR‐II) light oxygen bubbles, allowing effective treatment at deep tumor sites. Meanwhile, plasmonic AuNR‐MnO heterostructure facilitates separation electron–hole pairs generates reactive species (ROS), inducing immunogenic death under NIR‐II laser irradiation. Furthermore, reacts release Mn 2+ ions, activating cGAS‐STING pathway enhancing antitumor immunity. In vitro vivo experiments demonstrate that these achieve active targeting infiltration, promoting M1 polarization, dendritic maturation, effector T‐cell activation, thereby catalysis immunotherapy ROS production STING activation.

Language: Английский

Citations

A Slimming/Excavating Strategy for Enhanced Intratumoral Penetration of Acid‐Disassemblable NO‐Releasing Nanomedicines DOI

Lingdong Jiang,

An‐Bang Wu,

Lingting Zeng

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Abstract Poor tumor penetration is the major predicament of nanomedicines that limits their anticancer efficacy. The dense extracellular matrix (ECM) in one barriers against deep nanomedicines. In this work, a slimming/excavating strategy proposed for enhanced intratumoral based on an acid‐disassemblable nanomicelles‐assembled nanomedicine and NO‐mediated degradation ECM. constructed by cross‐linking nanomicelles, which are self‐assembled with two kinds dendrimers containing phenylboronic acid lactobionic acid, through borate esterification. acidic microenvironment, pH‐sensitive ester bonds among nanomicelles hydrolyzed, triggering disassembly (≈150 nm) into small (≈25 nm). response to over‐expressed glutathione (GSH), NO donor loaded produces NO, mediates expression metalloproteinases ECM tumor. By collaboration disassembling behavior ECM, designed can penetrate long distance tumors. will provide inspiration overcoming challenge penetration.

Language: Английский

Citations

Janus micro/nanomotors for enhanced disease treatment through their deep penetration capability DOI

Haoran Ma, Yuxuan Guo, Xia Xu

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

Integration of Photodiagnosis and Therapy Guided by Micro/Nanorobots DOI

Qihang Ding, Siqi Huang, Zihan Zhang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Micro/Nanorobots(MNRs)integrated with phototherapy represent an emerging approach to cancer treatment and hold significant potential for addressing bacterial infections, neurological disorders, cardiovascular diseases, related conditions. By leveraging micro/nanoscale motor systems in conjunction phototherapy, these robots enable real-time guidance monitoring of therapeutic processes, improving drug delivery precision efficiency. This integration not only enhances the effectiveness but also minimizes damage surrounding healthy tissues. Nevertheless, clinical translation MNRs-assisted still faces numerous challenges. In this review, recent key developments field are comprehensively summarized, critical roles applications highlighted, insights into future directions pathway toward large-scale implementation provided.

Language: Английский

Citations

Tumor-Activated Nanoassemblies with Positive Feedback Loop for Photoacoustic Imaging-Guided Precise Cancer Therapy DOI

Xuan Wang, Xiaotong Xing, Mingjie Dong

et al.

ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1737 - 1745

Published: April 3, 2025

Language: Английский

Citations

Ph/Gsh Dual-Responsive Janus-Type Au@H-Mp@Dox Mr Molecular Imaging Nanomotor for Combined Photothermal/Chemotherapeutic Treatment of Pancreatic Cancer DOI

Hao Zhang,

Dan Xie, Meng Chen

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

Nanomotor-Driven Precision Therapy for Peritoneal Metastasis DOI

Yaoguang She,

Jianxin Cui, Jiamin Ye

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123354 - 123354

Published: April 1, 2025

Language: Английский

Citations

Application of metal polyphenol nanonetworks in phototherapy DOI

Siwei Li, Meng Cui,

Chunxiu Cai

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 539, P. 216743 - 216743

Published: April 23, 2025

Language: Английский

Citations

Multifunctional Cascade Theranostic Agents for Synergistic Photothermal/Ferroptosis/Immuno Antitumor Therapy DOI

Haoran Chen, Fei Long,

Dechao Gan

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 253, P. 114740 - 114740

Published: April 28, 2025

Language: Английский

Citations

Synthesis of polyacrylic acid-coated AuPd@Fe_xO_y nanoparticles for synergistic chemodynamic and photothermal therapy of osteosarcoma DOI

Zeping Liu,

Sun Haoyu,

Yongjie Shan

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

PAA-AuPd@Fe x O y NPs enable pH-responsive T 1 MRI-guided CDT–PTT for osteosarcoma. could generate ˙OH via Fenton reaction and enhance ROS under an 808 nm NIR laser, effectively suppressing MG63 tumor growth in mice.

Language: Английский

Citations