Hydrogel-Based Bioactive Synthetic Skin Stimulates Regenerative Gas Signaling and Eliminates Interfacial Pathogens to Promote Burn Wound Healing DOI
Haifeng Zhang, Wei Zhou, Haibing Wang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Skin burn wounds (SBWs) are common clinical injuries due to excessive exposure factors including heat, radiation, chemical agents, etc. However, the efficient healing of SBWs is still challenging persistent inflammation and high risk local infection. To meet these challenges, we report a hydrogel-based bioactive synthetic skin (HBSS) from biocompatible components as dressing materials for wound treatment, which mediated localized H2S release stimulate tissue regeneration while preventing bacterial infection inflammation. Here, donor (N-(benzoyl mercapto) benzamide) was first coassembled with thioketal (TK)-ligated dopamine dimer form nanoscale assemblies (DDNs), were then integrated into Schiff base-cross-linked hyaluronic acid-carboxymethyl chitosan hydrogels. The elevated acidity in would trigger hydrogel degradation DDNs, further activated by ROS-induced cleavage TK linkers gas attenuating ROS stress self-immolative manner, thus promoting angiogenesis through activating AMPK RAS-MAPK-AP1 prohealing pathways, enabling M1-to-M2 macrophage reprogramming ERK1/2 NRF2 signaling. Meanwhile, network could inhibit colonization at site prevent These merits acted cooperative manner enable accelerated robust healing, offering an approach treatment clinic.

Language: Английский

Nanoparticle-Reinforced Hydrogel with a Well-Defined Pore Structure for Sustainable Drug Release and Effective Wound Healing DOI Creative Commons
Z. Zhang, Siyu Yang,

Feixue Mi

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Impaired chronic wounds are a common complication of diabetes. Inhibited angiogenesis and dysfunctional inflammation render diabetic wound healing critical challenge. Herein, sustainable therapeutic composite hydrogel is presented for healing, consisting cocktail formulation anti-inflammatory local anesthetic nanoparticles incorporated into hydrogel. The surface-modified drug loaded the biocompatible hydrogels cross-linked with gel precursor to enhance structure. delivery system achieves more than 90% release, total therapy duration tunable from 4 72 h. Through long-lasting analgesic effects hydrogel, swiftly transitioned proliferation phase, augmenting survival migration keratinocytes facilitating neovascularization collagen alignment in wounds. These significantly improve rate skin regeneration process, achieving that 17 times untreated This study demonstrates platform promising rapid

Language: Английский

Citations

0
Anti-inflammatory and antibacterial hydrogel based on a polymerizable ionic liquid DOI Creative Commons

J A Romero-Antolín,

Natividad Gómez‐Cerezo, Miguel Manzano

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Poly-T-Modified Gold Nanorods Suppress Macrophage-Mediated Inflammation for Periodontitis Therapy DOI

Wanghong He,

Wei Wei, Yifan Zhao

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Traditional treatments for periodontitis are limited by their inability to adequately modulate the immune response and control inflammation. Recently, nucleic acid-modified nanomaterials have attracted significant attention potential in regulating Among these, most nanomaterials, such as spherical acids, tend exhibit pro-inflammatory effects. In this study, we identified first time that poly-T sequence-modified gold nanorods (PTM AuNRs) possess anti-inflammatory properties. The PTM AuNRs demonstrated excellent biocompatibility efficacy treating ligation-induced periodontitis. responses inhibiting differentiation of M1 macrophages reducing cytokine levels through promoting AMPK activation. When administered via local injection, effectively suppress inflammatory cell infiltration, downregulate levels, mitigate collagen fiber degradation alveolar bone loss. Together, these findings highlight a promising innovative therapeutic strategy management.

Language: Английский

Citations

0
Hydrogel-Based Bioactive Synthetic Skin Stimulates Regenerative Gas Signaling and Eliminates Interfacial Pathogens to Promote Burn Wound Healing DOI
Haifeng Zhang, Wei Zhou, Haibing Wang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Skin burn wounds (SBWs) are common clinical injuries due to excessive exposure factors including heat, radiation, chemical agents, etc. However, the efficient healing of SBWs is still challenging persistent inflammation and high risk local infection. To meet these challenges, we report a hydrogel-based bioactive synthetic skin (HBSS) from biocompatible components as dressing materials for wound treatment, which mediated localized H2S release stimulate tissue regeneration while preventing bacterial infection inflammation. Here, donor (N-(benzoyl mercapto) benzamide) was first coassembled with thioketal (TK)-ligated dopamine dimer form nanoscale assemblies (DDNs), were then integrated into Schiff base-cross-linked hyaluronic acid-carboxymethyl chitosan hydrogels. The elevated acidity in would trigger hydrogel degradation DDNs, further activated by ROS-induced cleavage TK linkers gas attenuating ROS stress self-immolative manner, thus promoting angiogenesis through activating AMPK RAS-MAPK-AP1 prohealing pathways, enabling M1-to-M2 macrophage reprogramming ERK1/2 NRF2 signaling. Meanwhile, network could inhibit colonization at site prevent These merits acted cooperative manner enable accelerated robust healing, offering an approach treatment clinic.

Language: Английский

Citations

0