Engineered Photoactivatable Nanomicelles for Ferroptosis-like Combinational Tumor Therapy In Vitro and In Vivo DOI
Yandai Lin, Xinru Kong, Zhe Liu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Nitric oxide (NO)-based gas therapy has attracted increasing attention as a promising approach for tumor treatment, but elevated levels of glutathione (GSH) in the microenvironment significantly limit their therapeutic effectiveness. In this study, type engineered photoactivatable nanomicelles Ce6/NI@PEP@HA (CNPH) were developed combinational photodynamic and NO therapy. CNPH was capable targeted accumulation to tumors, where it depleted GSH released effectively produce reactive oxygen species (ROS) with oxidative damage under laser irradiation at 660 nm. The consumption induced deactivation peroxidase activity, leading enhanced toxic lipid peroxide enabled ferroptosis-like outcome. Additionally, effective production ROS resulted mitochondrial dysfunction, characterized by disruption membrane potential decreased adenosine triphosphate concentration. vivo animal experiments indicated that achieved inhibition 89.1%, proven be more strategy contrast any single modality. consequence, opened up new horizon cutting-edge noninvasive paradigm advanced treatments.

Language: Английский

Bioresponsive nanoreactor initiates cascade reactions for tumor vascular normalization and lactate depletion to augment immunotherapy DOI

Jiaoyu Chen,

Charlie Bu, Yuting Lu

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 317, P. 123100 - 123100

Published: Jan. 9, 2025

Language: Английский

Citations

0
Calcium peroxide functionalized mesoporous polydopamine nanoparticles triggered calcium overload for synergistic tumor gas/photothermal therapy DOI
Zhen Liu, Wei Hu, Yingying Cai

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 690, P. 137332 - 137332

Published: March 14, 2025

Language: Английский

Citations

0
Engineered Photoactivatable Nanomicelles for Ferroptosis-like Combinational Tumor Therapy In Vitro and In Vivo DOI
Yandai Lin, Xinru Kong, Zhe Liu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Nitric oxide (NO)-based gas therapy has attracted increasing attention as a promising approach for tumor treatment, but elevated levels of glutathione (GSH) in the microenvironment significantly limit their therapeutic effectiveness. In this study, type engineered photoactivatable nanomicelles Ce6/NI@PEP@HA (CNPH) were developed combinational photodynamic and NO therapy. CNPH was capable targeted accumulation to tumors, where it depleted GSH released effectively produce reactive oxygen species (ROS) with oxidative damage under laser irradiation at 660 nm. The consumption induced deactivation peroxidase activity, leading enhanced toxic lipid peroxide enabled ferroptosis-like outcome. Additionally, effective production ROS resulted mitochondrial dysfunction, characterized by disruption membrane potential decreased adenosine triphosphate concentration. vivo animal experiments indicated that achieved inhibition 89.1%, proven be more strategy contrast any single modality. consequence, opened up new horizon cutting-edge noninvasive paradigm advanced treatments.

Language: Английский

Citations

0