Molecular Dynamics Simulations of Hybrid Cell Membrane‐Coated Porphyrin Nanoparticles for Enhanced Photochemotherapy of Breast Cancer DOI
Shuping Wang,

Jun Lan,

Zhiqiang Ren

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 23, 2025

Abstract The construction of a bionic membrane drug delivery system introduces new opportunities and challenges for cancer treatment. Cell membrane‐coated nanoparticles can maintain inherent cellular properties, such as homologous homing, enhance the stability in complex blood environment. In this study, porphyrin carrier (Por) is designed synthesized to assemble with doxorubicin (Dox) construct Dox‐Por nanomicelles guided by computational simulations. mouse breast cell (4T1‐M) red (RBC‐M) are fused create hybrid biomimetic (TRM), which subsequently camouflaged on Dox‐Por, resulting Dox‐Por@TRM. This exhibits high loading, specific self‐recognition 4T1 cells, prolonged circulation time. Both vitro vivo anti‐tumor assessments demonstrates that Dox‐Por@TRM has enhanced combination therapy effects eliminate subcutaneous tumors single dose three laser irradiations. These findings provide feasible effective strategy combined photodynamic chemotherapy.

Language: Английский

Recent advances in metal-organic framework capabilities with machine learning innovations for enhanced drug release systems DOI

Minoosh Lalinia,

Nahid Hassanzadeh Nemati,

Parinaz Mofazali

et al.

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 45, P. 102640 - 102640

Published: March 18, 2025

Language: Английский

Citations

0
Molecular Dynamics Simulations of Hybrid Cell Membrane‐Coated Porphyrin Nanoparticles for Enhanced Photochemotherapy of Breast Cancer DOI
Shuping Wang,

Jun Lan,

Zhiqiang Ren

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 23, 2025

Abstract The construction of a bionic membrane drug delivery system introduces new opportunities and challenges for cancer treatment. Cell membrane‐coated nanoparticles can maintain inherent cellular properties, such as homologous homing, enhance the stability in complex blood environment. In this study, porphyrin carrier (Por) is designed synthesized to assemble with doxorubicin (Dox) construct Dox‐Por nanomicelles guided by computational simulations. mouse breast cell (4T1‐M) red (RBC‐M) are fused create hybrid biomimetic (TRM), which subsequently camouflaged on Dox‐Por, resulting Dox‐Por@TRM. This exhibits high loading, specific self‐recognition 4T1 cells, prolonged circulation time. Both vitro vivo anti‐tumor assessments demonstrates that Dox‐Por@TRM has enhanced combination therapy effects eliminate subcutaneous tumors single dose three laser irradiations. These findings provide feasible effective strategy combined photodynamic chemotherapy.

Language: Английский

Citations

0