Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Abstract Although initially identified as pathological aggregates, amyloid fibrillar assemblies formed by various proteins and peptides are now known to have crucial physiological roles, carrying out numerous biological functions in almost all organisms. Due unique features, the common etiology of amyloids’ cross‐β structure is long posited a template for designing artificial self‐assembling systems. However, recent discovery cross‐α amyloids indicates additional structural paradigms self‐assembly into ordered nanostructures, turning significant attention toward nanostructures based on assembly. Herein, minimalistic designer peptide which forms hydrogen‐bonded amyloid‐like while remaining α region conformation engineered, investigate effect aromatic, hydrophobic, steric considerations amyloidal assemblies. These results demonstrate modulation helicity self‐assembly, leading structure‐dependent piezoelectric function fibrils. This study potential avenue molecular engineering functional materials.

Language: Английский