Micromotion‐Driven “Mechanical‐Electrical‐Pharmaceutical Coupling” Bone‐Guiding Membrane Modulates Stress‐Concentrating Inflammation Under Diabetic Fractures DOI
Junhao Sui,

Yijin Hou,

Chen Ding

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract The use of piezoelectric materials to convert micromechanical energy at the fracture site into electrical signals, thereby modulating stress‐concentrated inflammation, has emerged as a promising treatment strategy for diabetic fractures. However, traditional bone‐guiding membranes often face challenges in repair due their passive and imprecise drug release profiles. Herein, polyvinylidene fluoride (PVDF) fibrous membrane is fabricated through electrospinning oxidative polymerization load metformin (Met) polypyrrole (PPy) coating (Met‐PF@PPy), creating “mechanical‐electrical‐pharmaceutical coupling” system. In micromotion mechanical environment, Met‐PF@PPy converts activating electrochemical reduction PPy triggering stress‐responsive Met release. generated signals suppress inflammation M1‐to‐M2 macrophage polarization simultaneously enhance osteogenesis. Simultaneously, inhibits NF‐κB pathway reduce pro‐inflammatory cytokines while AMPK promote osteogenesis angiogenesis. mouse femoral model, significantly reduces inflammatory markers, enhances vascularization, increases bone mineral density volume fraction by over 30%. This “force‐electric‐drug provides an innovative approach active regulation offers versatile platform advancing regenerative medicine.

Language: Английский

Micromotion‐Driven “Mechanical‐Electrical‐Pharmaceutical Coupling” Bone‐Guiding Membrane Modulates Stress‐Concentrating Inflammation Under Diabetic Fractures DOI
Junhao Sui,

Yijin Hou,

Chen Ding

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract The use of piezoelectric materials to convert micromechanical energy at the fracture site into electrical signals, thereby modulating stress‐concentrated inflammation, has emerged as a promising treatment strategy for diabetic fractures. However, traditional bone‐guiding membranes often face challenges in repair due their passive and imprecise drug release profiles. Herein, polyvinylidene fluoride (PVDF) fibrous membrane is fabricated through electrospinning oxidative polymerization load metformin (Met) polypyrrole (PPy) coating (Met‐PF@PPy), creating “mechanical‐electrical‐pharmaceutical coupling” system. In micromotion mechanical environment, Met‐PF@PPy converts activating electrochemical reduction PPy triggering stress‐responsive Met release. generated signals suppress inflammation M1‐to‐M2 macrophage polarization simultaneously enhance osteogenesis. Simultaneously, inhibits NF‐κB pathway reduce pro‐inflammatory cytokines while AMPK promote osteogenesis angiogenesis. mouse femoral model, significantly reduces inflammatory markers, enhances vascularization, increases bone mineral density volume fraction by over 30%. This “force‐electric‐drug provides an innovative approach active regulation offers versatile platform advancing regenerative medicine.

Language: Английский

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