Tailored Pore Architectures in Ti6Al4V Bone Scaffolds for Tunable Permeability and Mechanical Performance DOI
Chao Xu, Yulin Zhang, Lu Zhang

et al.

Advanced Engineering Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

To achieve multifunctionalities such as nutrient transport, cellular activities, and load‐bearing while avoiding stress shielding, bone tissue engineering scaffolds must exhibit consistent permeability mechanical properties comparable to those of human bones. Here, filament‐rotated, filament‐shifted, gradient, conventional Ti6Al4V are designed fabricated using direct ink writing. These high‐precision interconnective pores simultaneously match the elastic modulus with trabeculae. The impact internal pore architecture on is investigated systematically through experimental numerical methods. Compared scaffolds, alterations in structure result decreased modulus. influence porosity scaffold outweighs that architecture. shifted 100% exhibits a more uniform symmetrical distribution wall shear stress, which may promote cell adhesion proliferation. By tuning diverse architectures, wide range (e.g., values 1.12 × 10 −10 2.95 m 2 ) property moduli 1.0–5.7 GPa) can be achieved. A hierarchical, goal‐oriented selection framework proposed guide structural design patient‐specific across various anatomical sites.

Language: Английский

E7 peptide for in situ tissue engineering applications in bone repair DOI
Wentao Zhang, Kaizhong Wang, Moran Suo

et al.

Journal of the American Ceramic Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Abstract In regenerative medicine, leveraging bioactive molecules to enhance endogenous repair mechanisms represents a critical advancement. The E7 peptide, novel short has emerged as key candidate for bone defect due its unique ability interact with stem cells directly. Unlike traditional tissue‐engineered constructs that rely on exogenous cell delivery or scaffold‐based strategies, enables in situ regeneration by actively recruiting and anchoring the site. Studies demonstrate E7‐functionalized materials significantly proliferation osteogenic differentiation while concurrently stimulating local angiogenesis through VEGF upregulation. These dual effects—stem homing vascularization—address two major bottlenecks repair: insufficient supply poor nutrient diffusion avascular regions. Despite these advantages, optimizing E7's spatiotemporal presentation elucidating signaling remain critical. Further investigations into receptor specificity, dose dependency, long‐term safety will accelerate clinical translation. It is of great guiding significance clarify what role. peptide plays various which pathways are activated future research repair.

Language: Английский

Citations

0
Curcumin-Encapsulated Exosomes in Bisphosphonate-Modified Hydrogel Microspheres Promote Bone Repair through Macrophage Polarization and DNA Damage Mitigation DOI Creative Commons
Yunhui Si,

Shuao Dong,

Mengsha Li

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101874 - 101874

Published: May 1, 2025

Language: Английский

Citations

0
Tailored Pore Architectures in Ti6Al4V Bone Scaffolds for Tunable Permeability and Mechanical Performance DOI
Chao Xu, Yulin Zhang, Lu Zhang

et al.

Advanced Engineering Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

To achieve multifunctionalities such as nutrient transport, cellular activities, and load‐bearing while avoiding stress shielding, bone tissue engineering scaffolds must exhibit consistent permeability mechanical properties comparable to those of human bones. Here, filament‐rotated, filament‐shifted, gradient, conventional Ti6Al4V are designed fabricated using direct ink writing. These high‐precision interconnective pores simultaneously match the elastic modulus with trabeculae. The impact internal pore architecture on is investigated systematically through experimental numerical methods. Compared scaffolds, alterations in structure result decreased modulus. influence porosity scaffold outweighs that architecture. shifted 100% exhibits a more uniform symmetrical distribution wall shear stress, which may promote cell adhesion proliferation. By tuning diverse architectures, wide range (e.g., values 1.12 × 10 −10 2.95 m 2 ) property moduli 1.0–5.7 GPa) can be achieved. A hierarchical, goal‐oriented selection framework proposed guide structural design patient‐specific across various anatomical sites.

Language: Английский

Citations

0