Hydrogels with programmed spatiotemporal mechanical cues for stem cell-assisted bone regeneration

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 16, 2025

Hydrogels are extensively utilized in stem cell-based tissue regeneration, providing a supportive environment that facilitates cell survival, differentiation, and integration with surrounding tissues. However, designing hydrogels for regenerating hard tissues like bone presents significant challenges. Here, we introduce macroporous spatiotemporally programmed mechanical properties cell-driven regeneration. Using liquid-liquid phase separation interfacial supramolecular self-assembly of protein fibres, the structure provide ample space to prevent contact inhibition during proliferation. The rigid fibre-coated pore shell provides sustained cues guiding osteodifferentiation protecting against loads. Temporally, hydrogel exhibits tunable degradation rates can synchronize new deposition some extent. By integrating localized heterogeneity, structures, surface chemistry, regenerative degradability, demonstrate efficacy these cell-encapsulated rabbit porcine models. This marks substantial advancement tailoring cell-assisted

Language: Английский

Bismuth-Nanosheet-Armed Pristine Silk Nanofiber Dressing for Multimodal Pathogenic Bacteria Eradication and Infected Wound Healing

Advanced Fiber Materials, Journal Year: 2025, Volume and Issue: unknown

Published: June 3, 2025

Language: Английский