Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216608 - 216608
Published: March 27, 2025
Language: Английский
Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 30, 2025
Early detection and precise treatment for breast cancer are crucial, given its high global incidence rate. Hence, the development of novel imaging targets is essential diagnosing monitoring resistance to chemotherapy, which pivotal achieving personalized patients. In our previous work, we successfully developed a near-infrared (NIR) probe 1 CYP1B1-targeted imaging. this study, aimed investigate utility as NIR fluorescence photoacoustic dual-mode surveillance cancer. Western blotting cell lines has confirmed that CYP1B1 widely expressed in gynecological vitro capability tracking CYP1B1-positive tumor cells was validated by using confocal microscopy. Further studies, including vivo dual-model ex biological distribution analysis on triple-negative xenograft mouse model, demonstrated selectively accumulated tissue within early 0.5 h postinjection. The results surgical resection experiment revealed could be entirely removed under guidance imaging, thereby indicating probe's efficacy navigation. expression found upregulated adriamycin (ADR)-resistant cells, MCF-7/ADR. Consequently, sensitivity overexpressed MCF-7/1B1, ADR significantly reduced, with an IC50 value 0.586 ± 0.0934 μM, compared parental MCF-7 0.183 0.0444 μM. assays conducted MCF-7/ADR tumor-bearing mice specifically enriched sites, suggesting potential chemotherapy This study expands scope application 1, establishing diagnosis through fluorescence-photoacoustic resistance, resection. strategy paves way approaches
Language: Английский
Citations
0
Beilstein Journal of Nanotechnology, Journal Year: 2025, Volume and Issue: 16, P. 195 - 215
Published: Feb. 17, 2025
The human eye, with its remarkable resolution of up to 576 million pixels, grants us the ability perceive world astonishing accuracy. Despite this, over 2 billion people globally suffer from visual impairments or blindness, primarily because limitations current ophthalmic treatment technologies. This underscores an urgent need for more advanced therapeutic approaches effectively halt even reverse progression eye diseases. rapid advancement nanotechnology offers promising pathways development novel therapies. Notably, photothermal nanomaterials, particularly well-suited transparent tissues have emerged as a potential game changer. These materials enable precise and controllable therapy by manipulating distribution thermal field. Moreover, they extend beyond conventional boundaries therapy, achieving unparalleled effects through their diverse composite structures demonstrating enormous in promoting retinal drug delivery photoacoustic imaging. paper provides comprehensive summary structure-activity relationship between properties these nanomaterials innovative mechanisms. We review latest research on nanomaterial-based treatments various Additionally, we discuss challenges future perspectives this field, focus enhancing global health.
Language: Английский
Citations
0
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: March 18, 2025
Effective immunotherapeutic treatment of solid tumors has been greatly challenged by the complex hostile tumor immunosuppressive microenvironment (TIME), which typically involves hypoxia and immunosuppression. Herein, a multifunctional biomimetic gold nano-modulator (denoted as GNR-SNO@MMT) was developed to realize efficient second near-infrared (NIR-II) photothermal immunotherapy via targeting deep penetration, vascular normalization immune reprogramming. NIR-II agent nanorods (GNR) were grafted with thermosensitive S-nitrosothiol (SNO) donors camouflaged tumor-penetrating peptide tLyp-1-modified macrophage membrane (MM) yield GNR-SNO@MMT. The engineered coating increased capacity for inflammatory tropism aided GNR-SNO@MMT in ablating together laser irradiation. Moreover, hyperthermia-stimulated nitric oxide (NO) release situ acted gas immunomodulator effectively enhance blood perfusion reprogram TIME multiple functions (e.g., decreasing PD-L1, repolarizing tumor-associated macrophages, revitalizing cytotoxic T cells). Ultimately, inhibition rate against 4T1 mouse mammary model mediated plus 94.7% 2.4-fold CD8+ cells infiltrated into than that untreated counterpart. provides an effective novel photoimmunotherapy candidate deep-sited through reconfiguration NO-involved nanomedicine external assistance.
Language: Английский
Citations
0
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216608 - 216608
Published: March 27, 2025
Language: Английский
Citations
0