Photogenetic‐Like Liposomes Disrupt Neuroligin‐3 Dependency to Enhance Glioma Treatment DOI

Mengbin Ding,

Peng Liu, Yuan Xue

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract Neuronal activity is shown to potentiate glioma initiation, progression, and/or metastasis. A key mechanism in neural regulation of brain cancer involves the activity‐dependent cleavage and release synaptic adhesion molecule neuroligin‐3 (NLGN3). Here, this report describes preparation optogenetics‐like liposome Lip‐CuRA, which used regulate content NLGN3 neurons mediate phototherapy cells. Lip‐CuRA contains upconversion nanoparticles encapsulating CuS (CuS@PUCNPs), a visible light‐activated neurotransmitter prodrug RuBi‐GABA, disintegrin metalloproteinase (ADAM10) inhibitors GI254023X. Upon 980 nm laser irradiation, photothermal conversion not only induces tumor cell apoptosis, but also destroys structure, releasing Rubi‐GABA The UCNPs convert into 540 nm, activating RuBi‐GABA GABA. GABA selectively opens Cl⁻ channels nerve cells, reducing expression degree axonal connections. GI254023X inhibits ADAM10 enzyme on surface, NLGN3, thereby blocking transmission proliferation stemness signals. In GL261‐luc orthotopic model, C6‐luc patient‐derived xenograft (PDX) effectively recurrence, reduces stemness, extends survival through synergistic NLGN3‐regulating therapy.

Language: Английский

Semiconducting Polymers Containing Benzobisthiadiazole Based on Donor Conjugation Extension Strategy Enabling NIR-II Photoacoustic Imaging Performance Improvement DOI
Tiantian Zhou, Zhixiong Cao, Qian Li

et al.

ACS Applied Polymer Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Language: Английский

Citations

0
Photogenetic‐Like Liposomes Disrupt Neuroligin‐3 Dependency to Enhance Glioma Treatment DOI

Mengbin Ding,

Peng Liu, Yuan Xue

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract Neuronal activity is shown to potentiate glioma initiation, progression, and/or metastasis. A key mechanism in neural regulation of brain cancer involves the activity‐dependent cleavage and release synaptic adhesion molecule neuroligin‐3 (NLGN3). Here, this report describes preparation optogenetics‐like liposome Lip‐CuRA, which used regulate content NLGN3 neurons mediate phototherapy cells. Lip‐CuRA contains upconversion nanoparticles encapsulating CuS (CuS@PUCNPs), a visible light‐activated neurotransmitter prodrug RuBi‐GABA, disintegrin metalloproteinase (ADAM10) inhibitors GI254023X. Upon 980 nm laser irradiation, photothermal conversion not only induces tumor cell apoptosis, but also destroys structure, releasing Rubi‐GABA The UCNPs convert into 540 nm, activating RuBi‐GABA GABA. GABA selectively opens Cl⁻ channels nerve cells, reducing expression degree axonal connections. GI254023X inhibits ADAM10 enzyme on surface, NLGN3, thereby blocking transmission proliferation stemness signals. In GL261‐luc orthotopic model, C6‐luc patient‐derived xenograft (PDX) effectively recurrence, reduces stemness, extends survival through synergistic NLGN3‐regulating therapy.

Language: Английский

Citations

0