Spatiotemporally Programming Microenvironment to Recapitulate Endochondral Ossification via Greenhouse‐Inspired Bionic Niche DOI
Xuzheng Liu,

Yaning Zhao,

Xiaoyi Wu

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Abstract Various biomaterials have been developed to address challenging critical‐sized bone defects. However, most of them focus on intramembranous ossification (IMO) rather than endochondral (ECO), often resulting in suboptimal therapeutic outcomes. Drawing inspiration from the functionality greenhouse ecosystem, herein a bionic niche is innovatively crafted recapitulate ECO process. This consists three hierarchical components: an embedded microchannel network that facilitates cell infiltration and matter exchange, polydopamine surface modification layer with immunomodulatory functions, ECO‐targeted delivery system based mesoporous silica nanoparticles. Through spatiotemporally programming microenvironment, effectively recapitulates key stages ECO. Notably, even rat calvaria, region well‐known for IMO, capable initiating ECO, evident by cartilage template formation, leading efficient regeneration. Taken together, this study introduces prospective concepts designing next‐generation ECO‐driven tissue engineering.

Language: Английский

Spatiotemporally Programming Microenvironment to Recapitulate Endochondral Ossification via Greenhouse‐Inspired Bionic Niche DOI
Xuzheng Liu,

Yaning Zhao,

Xiaoyi Wu

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Abstract Various biomaterials have been developed to address challenging critical‐sized bone defects. However, most of them focus on intramembranous ossification (IMO) rather than endochondral (ECO), often resulting in suboptimal therapeutic outcomes. Drawing inspiration from the functionality greenhouse ecosystem, herein a bionic niche is innovatively crafted recapitulate ECO process. This consists three hierarchical components: an embedded microchannel network that facilitates cell infiltration and matter exchange, polydopamine surface modification layer with immunomodulatory functions, ECO‐targeted delivery system based mesoporous silica nanoparticles. Through spatiotemporally programming microenvironment, effectively recapitulates key stages ECO. Notably, even rat calvaria, region well‐known for IMO, capable initiating ECO, evident by cartilage template formation, leading efficient regeneration. Taken together, this study introduces prospective concepts designing next‐generation ECO‐driven tissue engineering.

Language: Английский

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