Montmorillonite Modulates Manganese d‐Band Center to Enhance Cascade Reaction Activity Against Inflammatory Bowel Disease DOI
Qianqian Liu,

Weimin Xie,

Juan Liao

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 26, 2025

Abstract Antioxidant cascade nanozymes demonstrate significant potential for treating inflammatory bowel disease (IBD) by eliminating excess reactive oxygen species (ROS). However, developing oral antioxidant with stable and efficient superoxide dismutase‐catalase (SOD‐CAT) activity remains challenging. Herein, montmorillonite (MMT) is employed to modulate the upward shift of MnO 2‐x d‐band center, thereby enhancing its SOD‐CAT stability. Both experimental theoretical analyses reveal that strong interfacial interaction between MMT improves stability, reduces vacancy formation energy , elevates Mn center. This enhances adsorption key intermediates, such as *OH *O 2 in SOD CAT reaction pathways, which turn lowers barrier rate‐determining step. @MMT effectively scavenges intracellular ROS through reaction. Transcriptomic analysis further elucidates molecular mechanisms alleviates cellular oxidative stress activating autophagy mitophagy pathways. Furthermore, accumulates at site enteritis via electrostatic adsorption, exerting therapeutic effects facilitating restoration intestinal microecology. Collectively, utilizing minerals nanozyme center offers novel insights design materials targeting IBD.

Language: Английский

Synergizing Artificial Intelligence and Probiotics: A Comprehensive Review of Emerging Applications in Health Promotion and Industrial Innovation DOI
Xin Han,

Q. D. Liu,

Yun Li

et al.

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104938 - 104938

Published: Feb. 1, 2025

Language: Английский

Citations

6
Enzyme- and Nanozyme-Based food allergen detections: from natural biocatalysts to rational engineering approaches DOI Creative Commons
Shuang Wu, Jinlong Zhao, Youfa Wang

et al.

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 105016 - 105016

Published: April 1, 2025

Language: Английский

Citations

0
Advances of Metal‐Based Nanomaterials in the Prevention and Treatment of Oral Infections DOI
Junnan Qi,

Chao Si,

Haofeng Liu

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

The complicated environment of the oral cavity presents significant challenges to traditional antibacterial approaches, which has driven exploration novel therapeutic strategies. Metal-based nanomaterials (MNMs), with diverse mechanisms (e.g., membrane disruption, oxidative stress) and evolution from empirical theory-guided design, exhibit immense potential. This review introduces pioneering Hierarchical Response Strategy Framework, systematically classifying MNM systems into three progressive levels: Primary category, comprising MNMs that exert spontaneous effects based on inherent physicochemical properties ion release); Secondary including precisely controlled actions by microenvironmental or stimulus-responsive light-induced ROS); Tertiary encompassing integrate regenerative functions for multidimensional therapy remineralization). Through this framework, authors elucidate MNMs' transition single-function precision-controlled, multifunctional synergy, analyze impact metal elements structural design efficacy, summarize their applications in dental caries, endodontic infections, periodontal disease, etc. framework offers a perspective existing research theoretical foundation rational next-generation precise, smart, comprehensive anti-infective materials.

Language: Английский

Citations

0
Construction of Sonosensitizer‐Drug Co‐Assembly Based on Deep Learning Method DOI
Kanqi Wang, Liuyin Yang, Xiaowei Lu

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: May 16, 2025

Abstract Drug co‐assemblies have attracted extensive attention due to their advantages of easy preparation, adjustable performance and drug component co‐delivery. However, the lack a clear reasonable co‐assembly strategy has hindered wide application promotion drug‐co assembly. This paper introduces deep learning‐based sonosensitizer‐drug interaction (SDI) model predict particle size mixture. To analyze factors influencing after mixing, graph neural network is employed capture atomic, bond, structural features molecules. A multi‐scale cross‐attention mechanism designed integrate feature representations different scale substructures two drugs, which not only improves prediction accuracy but also allows for analysis impact molecular structures on predictions. Ablation experiments evaluate properties, comparisons with other machine learning methods show superiority, achieving 90.00% precision, 96.00% recall, 91.67% F1‐score. Furthermore, SDI predicts chemotherapy methotrexate (MET) sonosensitizer emodin (EMO) form nanomedicine NanoME. further validated through experiments, demonstrating that NanoME can be used fluorescence imaging liver cancer sonodynamic/chemotherapy anticancer therapy.

Language: Английский

Citations

0
Advanced Biomaterials and Delivery Modalities to Alleviate Cancer Therapy-Induced Inflammation DOI

Honglin Huang,

Qiaomei Ke,

Ningxi Li

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 324, P. 123419 - 123419

Published: May 20, 2025

Language: Английский

Citations

0
Montmorillonite Modulates Manganese d‐Band Center to Enhance Cascade Reaction Activity Against Inflammatory Bowel Disease DOI
Qianqian Liu,

Weimin Xie,

Juan Liao

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 26, 2025

Abstract Antioxidant cascade nanozymes demonstrate significant potential for treating inflammatory bowel disease (IBD) by eliminating excess reactive oxygen species (ROS). However, developing oral antioxidant with stable and efficient superoxide dismutase‐catalase (SOD‐CAT) activity remains challenging. Herein, montmorillonite (MMT) is employed to modulate the upward shift of MnO 2‐x d‐band center, thereby enhancing its SOD‐CAT stability. Both experimental theoretical analyses reveal that strong interfacial interaction between MMT improves stability, reduces vacancy formation energy , elevates Mn center. This enhances adsorption key intermediates, such as *OH *O 2 in SOD CAT reaction pathways, which turn lowers barrier rate‐determining step. @MMT effectively scavenges intracellular ROS through reaction. Transcriptomic analysis further elucidates molecular mechanisms alleviates cellular oxidative stress activating autophagy mitophagy pathways. Furthermore, accumulates at site enteritis via electrostatic adsorption, exerting therapeutic effects facilitating restoration intestinal microecology. Collectively, utilizing minerals nanozyme center offers novel insights design materials targeting IBD.

Language: Английский

Citations

0