Synergizing Artificial Intelligence and Probiotics: A Comprehensive Review of Emerging Applications in Health Promotion and Industrial Innovation
Xin Han,
No information about this author
Q. D. Liu,
No information about this author
Yun Li
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et al.
Trends in Food Science & Technology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 104938 - 104938
Published: Feb. 1, 2025
Language: Английский
Enzyme- and Nanozyme-Based food allergen detections: from natural biocatalysts to rational engineering approaches
Trends in Food Science & Technology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 105016 - 105016
Published: April 1, 2025
Language: Английский
Advances of Metal‐Based Nanomaterials in the Prevention and Treatment of Oral Infections
Junnan Qi,
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Chao Si,
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Haofeng Liu
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et al.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 17, 2025
The
complicated
environment
of
the
oral
cavity
presents
significant
challenges
to
traditional
antibacterial
approaches,
which
has
driven
exploration
novel
therapeutic
strategies.
Metal-based
nanomaterials
(MNMs),
with
diverse
mechanisms
(e.g.,
membrane
disruption,
oxidative
stress)
and
evolution
from
empirical
theory-guided
design,
exhibit
immense
potential.
This
review
introduces
pioneering
Hierarchical
Response
Strategy
Framework,
systematically
classifying
MNM
systems
into
three
progressive
levels:
Primary
category,
comprising
MNMs
that
exert
spontaneous
effects
based
on
inherent
physicochemical
properties
ion
release);
Secondary
including
precisely
controlled
actions
by
microenvironmental
or
stimulus-responsive
light-induced
ROS);
Tertiary
encompassing
integrate
regenerative
functions
for
multidimensional
therapy
remineralization).
Through
this
framework,
authors
elucidate
MNMs'
transition
single-function
precision-controlled,
multifunctional
synergy,
analyze
impact
metal
elements
structural
design
efficacy,
summarize
their
applications
in
dental
caries,
endodontic
infections,
periodontal
disease,
etc.
framework
offers
a
perspective
existing
research
theoretical
foundation
rational
next-generation
precise,
smart,
comprehensive
anti-infective
materials.
Language: Английский
Construction of Sonosensitizer‐Drug Co‐Assembly Based on Deep Learning Method
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 16, 2025
Abstract
Drug
co‐assemblies
have
attracted
extensive
attention
due
to
their
advantages
of
easy
preparation,
adjustable
performance
and
drug
component
co‐delivery.
However,
the
lack
a
clear
reasonable
co‐assembly
strategy
has
hindered
wide
application
promotion
drug‐co
assembly.
This
paper
introduces
deep
learning‐based
sonosensitizer‐drug
interaction
(SDI)
model
predict
particle
size
mixture.
To
analyze
factors
influencing
after
mixing,
graph
neural
network
is
employed
capture
atomic,
bond,
structural
features
molecules.
A
multi‐scale
cross‐attention
mechanism
designed
integrate
feature
representations
different
scale
substructures
two
drugs,
which
not
only
improves
prediction
accuracy
but
also
allows
for
analysis
impact
molecular
structures
on
predictions.
Ablation
experiments
evaluate
properties,
comparisons
with
other
machine
learning
methods
show
superiority,
achieving
90.00%
precision,
96.00%
recall,
91.67%
F1‐score.
Furthermore,
SDI
predicts
chemotherapy
methotrexate
(MET)
sonosensitizer
emodin
(EMO)
form
nanomedicine
NanoME.
further
validated
through
experiments,
demonstrating
that
NanoME
can
be
used
fluorescence
imaging
liver
cancer
sonodynamic/chemotherapy
anticancer
therapy.
Language: Английский
Advanced Biomaterials and Delivery Modalities to Alleviate Cancer Therapy-Induced Inflammation
Honglin Huang,
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Qiaomei Ke,
No information about this author
Ningxi Li
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et al.
Biomaterials,
Journal Year:
2025,
Volume and Issue:
324, P. 123419 - 123419
Published: May 20, 2025
Language: Английский
Montmorillonite Modulates Manganese d‐Band Center to Enhance Cascade Reaction Activity Against Inflammatory Bowel Disease
Qianqian Liu,
No information about this author
Weimin Xie,
No information about this author
Juan Liao
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et al.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 26, 2025
Abstract
Antioxidant
cascade
nanozymes
demonstrate
significant
potential
for
treating
inflammatory
bowel
disease
(IBD)
by
eliminating
excess
reactive
oxygen
species
(ROS).
However,
developing
oral
antioxidant
with
stable
and
efficient
superoxide
dismutase‐catalase
(SOD‐CAT)
activity
remains
challenging.
Herein,
montmorillonite
(MMT)
is
employed
to
modulate
the
upward
shift
of
MnO
2‐x
d‐band
center,
thereby
enhancing
its
SOD‐CAT
stability.
Both
experimental
theoretical
analyses
reveal
that
strong
interfacial
interaction
between
MMT
improves
stability,
reduces
vacancy
formation
energy
,
elevates
Mn
center.
This
enhances
adsorption
key
intermediates,
such
as
*OH
*O
2
in
SOD
CAT
reaction
pathways,
which
turn
lowers
barrier
rate‐determining
step.
@MMT
effectively
scavenges
intracellular
ROS
through
reaction.
Transcriptomic
analysis
further
elucidates
molecular
mechanisms
alleviates
cellular
oxidative
stress
activating
autophagy
mitophagy
pathways.
Furthermore,
accumulates
at
site
enteritis
via
electrostatic
adsorption,
exerting
therapeutic
effects
facilitating
restoration
intestinal
microecology.
Collectively,
utilizing
minerals
nanozyme
center
offers
novel
insights
design
materials
targeting
IBD.
Language: Английский